Prof. Xuhui Huang of the Department of Chemistry, along with co-PIs Computer Faculty Sharon Li and Professor of Pharmacy Weiping Tang have won a Research Forward 2024 Award for a project entitled “A novel deep learning platform in design molecular glues that stabilize protein-protein interactions,” that is using AI to identify molecular glues relevant to the development of cancer-fighting drugs. These “molecular glues” can stabilize protein-protein interactions (PPIs) and have emerged as a promising class of therapeutics for many ‘undruggable’ proteins. The team aims to identify molecular glues for the degradation of cancer-associated proteins and ultimately would help design drugs to fight cancer.
