The Smith Group is an interdisciplinary group of researchers developing new technologies to drive biological research. The focus of the lab is the development of new mass spectrometric technologies for the comprehensive identification and quantification of proteoforms in complex systems. This involves the development of improved strategies and tools for bottom-up, top-down, and intact mass proteomics, spanning the fields of Chemistry, Biochemistry, Bioinformatics, Genomics, and more. We apply these tools and drive their development in important biological systems with the aid of talented biologist and clinician collaborators.