Chemical strategy hints at better drugs for osteoporosis, diabetes

By swapping replacement parts into the backbone of a synthetic hormone, UW-Madison graduate student Ross Cheloha and his mentor Sam Gellman, along with collaborators at Harvard Medical School, have built a version of a parathyroid hormone that resists degradation in laboratory mice. As a result, the altered hormone can stay around longer - and at much higher concentration, says Gellman, professor of chemistry at the UW.

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