Tehshik P. Yoon
Position title: Professor of Chemistry
Room 5317A, Department of Chemistry
1101 University Avenue
Madison, WI 53706
- Research Website
- Yoon Group
- Research Interests
- Catalysis, Mechanism & Theory, Organometallics, Physical Organic, Synthesis, Photochemistry
- A.B. 1996, Harvard University
- Ph.D. 2002, California Institute of Technology
Research in the Yoon group focuses on the development of new reaction methods for organic synthesis. We are particularly interested in the use of catalysis as a strategy for increasing process efficiency, controlling reaction selectivity, and reducing the environmental impact of chemical synthesis. Representative project areas include the following.
Visible Light Photocatalysis. Photochemical reactions are intriguing from a synthetic perspective because the stereochemistry, regiochemistry, and chemoselectivity of organic reactions can differ dramatically under conditions of either thermal or photochemical activation. Yet organic chemists have long been reluctant to use photochemical reactions in complex molecule synthesis, and the properties of the structures that are uniquely accesible using photochemical activation have thus been relatively unexplored. A central goal of our research is to develop photochemical methods that can conveniently be conducted by any synthetic organic chemist, using sources of visible light that are already present in a standard chemistry lab. We focus upon the photoactivity of the transition metal chromophores that have been extensively exploited in the design of technologies for solar energy conversion. We have shown that complexes such as Ru(bpy)32+ and its derivatives can also be used to photochemically activate organic molecules towards a wide range of synthetically useful transformations.
Enantioselective Photochemistry. Photochemists have been interested in controling the stereochemistry of photochemical reactions for well over a century, but this has proven to be a remarkably challenging problem, with few general solutions. Several years ago, our laboratory introduced a concetually novel strategy that combines the robust photochemistry of transition metal photocatalysts with the well-understood stereocontrolling ability of chiral Lewis acid catalysts. This dual-catalysis strategy is highly flexible, and we have shown that it is applicable to a range of mechanistically distinct photocatalytic transformations.
Synthesis of Target Molecules. As synthetic chemists, we are inspired by the beauty of structurally complex natural products and by the need to produce complex pharmaceutical compounds using ever cleaner and more efficient synthetic processes. Target-oriented synthesis, therefore, is an important goal of our research, both as a benchmark by which to test the methods developed in our laboratory and as an inspiration that guides our research program.