Thesis Defense

Asymmetric photochemical methods offer powerful routes to complex chiral molecules. Herein, we detail advancements on the Paternò–Büchi reaction. We report the development of the first enantioselective catalytic variant, providing a versatile strategy for accessing enantiopure oxetanes, key structural motifs in biologically active compounds. Building on this, we introduce the intermolecular transposed Paternò–Büchi reaction, a novel approach enabled by overcoming limitations associated with alkene homodimerization. The research
contributes fundamental knowledge and practical methodologies to the field of asymmetric synthesis, with potential impact in areas ranging from photochemistry to drug development.