Stork-Organic Seminar – Prof. John Hartwig (University of California-Berkeley)

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1315 Seminar Hall
@ 3:30 pm - 4:30 pm

Title: Selective Catalytic Functionalizations of C-H and C=C Bonds


Abstract: The selective introduction of functional groups at the positions of typically unreactive C-H bonds has been a longstanding challenge in catalysis. To this end, our group has developed practical methods for the catalytic functionalization of C-H bonds with main group reagents.1-4 These studies have led us to a general strategy of installing a single transient functional group to form a range of products from one C-H bond functionalization reaction. This research has led us to seek next-generation catalysts for the functionalization of C-H in complex molecules, new classes of reactions for functionalization of these bonds, new strategies, such as the construction of artificial metalloenzymes to control the site at which such reactions occur,5 and new ways for such enzymes and natural enzymes to work in concert to form unnatural products through artificial biosynthetic pathways.6 The design and selection, as well as the intimate mechanism, of catalysts and catalytic reactions for such functionalization processes will be presented.

Host: Prof. Zach Wickens