Title: New Synthetic Methods for C–F Bond Formation: From Fundamental Science to Applications
Abstract: This presentation will describe our group’s recent advances in developing synthetic methods for introducing fluorine into organic molecules. Our efforts into this area are guided by detailed fundamental studies of stoichiometric organometallic bond-forming reactions. These fundamental studies will be described in detail, and their translation to practical applications (particularly in the context of the synthesis of PET imaging agents) will be discussed.
Bio: Melanie Sanford grew up in Providence, RI. She received her undergraduate degree in chemistry from Yale University in 1996 where she worked with Professor Bob Crabtree studying C–F bond functionalization. She then moved to Caltech where she worked with Professor Bob Grubbs investigating the mechanism of ruthenium-catalyzed olefin metathesis reactions. After receiving her PhD in 2001, she worked with Professor Jay Groves at Princeton University as an NIH post-doctoral fellow studying metalloporphyrin-catalyzed functionalization of olefins. Melanie has been a professor at the University of Michigan since the summer of 2003.
Host: Prof. Zach Wickens