Ruixian Han Thesis Defense

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Rm 1211, Biochemical Sciences Building.
@ 2:00 pm - 3:00 pm

Magic-angle spinning (MAS) solid-state NMR (SSNMR) is a powerful tool for investigating the structure and dynamics of solid and semi-solid samples. Developments in SSNMR instrumentation and methodology over the past few decades have greatly expanded the application of SSNMR in biological systems, but the technique inherently suffers from limitations in sensitivity, and many aspects of the SSNMR workflow can benefit from improved robustness and reliability. This work describes a series of technologies developed to improve the utilization of costly high field SSNMR instruments by developing better standards and protocols for sensitivity assessment, improving understanding of contributions to SSNMR sensitivity, optimization of SSNMR instruments, and improved reliability of rotor handling and instrument calibration procedures. These technologies have been extensively incorporated in the daily operation of the National Magnetic Resonance Facility at Madison (NMRFAM) and resulted in efficient data collection and extraordinary data quality over the years.