Department of Chemistry
College of Letters & Science

Meloche Lectureship/Analytical Seminar: Prof. Robert Graham Cooks (Purdue)

Riding the Ion Horse: Discoveries from the MS Saddle

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1315 Seminar Hall
@ 12:05 pm

Prof. Robert Graham Cooks

Title: Riding the Ion Horse: Discoveries from the MS Saddle

Bio:

Graham Cooks performed research under Frank Warren (South Africa), Peter Sykes (UK) and Dudley Williams (UK) before starting his independent career as an Assistant Professor of organic chemistry in 1968. He stepped off the tenure track treadmill two years later for a staff position at Purdue. His subsequent career in analytical chemistry has involved training some 50 group members for faculty positions, graduating 157 Ph.D. students and writing many papers (h-index 150). He is a member of several Academies and his group has been recognized through national and international awards including the Dreyfus Prize, the RSC Centenary Prize and the Boyle Medal.

Abstract:

Over the course of a long career, entirely spent doing mass spectrometry, with my group I have contributed to several discoveries, some of practical value. These are briefly indicated in this lecture with the unifying theme being that novel instrumentation represents the most fundamental science; applied sciences use instrumental tools to find their way.

• Tandem mass spectrometry (MS/MS for analysis of complex mixtures) [1]

• Ion soft landing (MS in materials preparation) [2]

• Tissue Imaging and diagnostics by DESI (MS imaging) [3]

• Kinetic method (thermochemical & stereochemical determinations by MS) [4]

• Surface-induced dissociation (MS/MS of biological molecules) [5]

• Chiral Enrichment and Transfer of Homochirality (Prebiotic chirality) [6]

• Accelerated reactions in microdroplets (MS as a synthetic method) [7]

• High throughput reaction screening and synthesis [8]

Note that the last two topics are treated in detail in the Friday lecture.

References

  1. Kondrat, R. W.; Cooks, R. G.; McLaughlin, J. L. Science, 1978, 199, 978-980.
  2. Miller, S. A.; Luo, H.; Pachuta, S. J.; Cooks, R. G. Science, 1997, 275, 1447-1450.
  3. Cooks, R. G.; Ouyang, Z.; Takata, Z.; Wiseman, J. M. Science, 2006, 311, 1566-70.
  4. McLuckey, S. A.; Cameron, D.; Cooks, R. G. J. Am. Chem. Soc., 1981, 103, 1313-17.
  5. Mabud, Md. A.; Dekrey, M. J.; Cooks, R. G. Int. J. Mass Spectrom., 1985, 67, 285-94.
  6. Nanita, S.; Cooks, R. G. Angew. Chem. Int. Ed., 2006, 45, 554-69.
  7. Muller, T.; Badu-Tawiah, A.; Cooks, R. G. Angew. Chem. Int. Ed., 2012, 51, 11832-5.
  8. Cooks, R. G.; Feng, Y.; Huang, K.-H.; Morato, N. M.; Qiu, L. Isr. J. Chem., 2023, e202300034.

Keywords: MS/MS; ion/surface collisions; interfacial reactions; reaction acceleration; chirality; cancer diagnostics

Faculty Host: Prof. Ying Ge