GSK/UW Symposium with Prof. Mark Levin (U. Chicago)

This event has passed.

Starting in Room 2401 and moving into the North Atrium and Learning Studio
@ 9:00 am - 6:30 pm

Levin-Mark- 2023

Join us in the Learning Studio for a day of graduate student, postdoc, and GSK scientist research presentations; a Q&A career panel; a 1st-3rd year lunch; a keynote seminar by Prof. Mark Levin, “Single Atom Logic for Skeletal Editing” ; and a poster session with refreshments.

Contact Spencer Heins or Mandi Thies if you or your students are interested in presenting.

Abstract:  Reactions that can manipulate the connectivity of the molecular skeleton are underexplored as tools for late-stage functionalization, in part because their implementation has been hindered by their often nonintuitive retrosynthetic logic. This presentation will cover selected transformations discovered in our laboratory which address this challenge by enabling single-atom changes to aliphatic and aromatic systems through the insertion and deletion of single heavy atoms (C,N,O, etc.), as well as more complex manipulations leveraging combinations of these elementary transformations. Our approach to this problem is modality-agnostic, drawing from a wide range of reactive species and synthetic disciplines, but with a significant focus on reagent design and photochemistry. Applications to late-stage functionalization and diversification of complex pharmaceutically relevant compounds as well as unique opportunities for synthesis will be presented alongside mechanistic findings.

Speaker bio: POSITIONS AND EDUCATION University of Chicago Assistant Professor (2019 – 2022) Associate Professor (2022 – Present) effective 9/1/22 Harvard University NIH Postdoctoral Fellow (2017-2019) Advisor: Eric N. Jacobsen University of California, Berkeley Ph.D. in Chemistry (2012-2017) NSF Graduate Research Fellow ARCS Graduate Research Fellow Advisor: F. Dean Toste University of Rochester B.S. in Chemistry (2008-2012) Advisor: Alison J. Frontier