Chemical Biology Seminar: Dr. Robert Tycko (National Institutes of Health)

1315 Seminar Hall
@ 3:30 pm

Title: Solid state NMR of protein folding and self-assembly with millisecond time-resolution

Abstract: 
Over the past several years, my lab has developed and applied new methods for probing time-dependent structural changes in biomolecular systems on the millisecond time scale, based on rapid mixing, rapid inverse temperature jumps, rapid freezing, and low-temperature solid state NMR. I will describe results from these “time-resolved solid state NMR” experiments, including results from studies of protein folding, formation of calmodulin/peptide complexes, oligomerization of amyloid-beta peptides, and liquid-liquid phase separation by intrinsically disordered, low-complexity proteins.

Bio: https://www.niddk.nih.gov/about-niddk/staff-directory/biography/tycko-robert

Keywords: protein folding, calmodulin, amyloid, phase separation, magnetic resonance