Title: Deciphering Proteostasis Regulation by Quantitative Mass Spectrometry
Abstract:
Proteostasis requires the coordinated control of protein synthesis, degradation, and post-translational modification, yet its dynamic regulation remains incompletely understood. In this seminar, I will discuss how quantitative mass spectrometry can advance measurement science beyond static proteome profiling to enable the systematic analysis of protein turnover as a central dimension of proteome regulation. I will highlight our work in two areas: proteome turnover control in aneuploidy, where chromosome imbalance imposes major challenges to protein homeostasis, and the interplay between protein turnover and post-translational modifications, particularly phosphorylation-dependent regulation of protein degradation. Together, these studies reveal unexpected principles of proteostasis regulation in health and disease.
Bio:
Dr. Yansheng Liu is an Associate Professor in the Department of Pharmacology at Yale University School of Medicine and a secondary faculty member in the Department of Biomedical Informatics & Data Science (BIDS). He leads a group specializing in quantitative proteomics at the Yale Cancer Biology Institute.
Dr. Liu earned his Ph.D. in Biomedical Sciences from the Chinese Academy of Sciences in 2011 and completed postdoctoral training at ETH Zurich under the mentorship of Ruedi Aebersold. Since joining Yale’s faculty in 2018, his research has centered on analyzing protein turnover and post-translational modifications to unravel the complexities of cell aneuploidy, cancer signaling pathways, and phenotype heterogeneity. His lab is also dedicated to advancing multiplexed data-independent acquisition mass spectrometry (DIA-MS), proteomics, phosphoproteomics, and recently MALDI imaging mass spectrometry (MALDI-MSI) based spatial omics and single-cell lipidomics for clinical applications and diseases.
Dr. Liu’s contributions have been recognized with several prestigious national and international awards, including the ASMS Research Award, the HUPO Early Career Researcher Award, and the US HUPO Robert J. Cotter Award.
Keywords: Mass spectrometry, protein turnover, aneuploidy, PTM