Title: Development of a Scalable Multi-Stage Flow Reaction for the Synthesis of Phospholigands
Abstract:
The synthesis of complex small molecule active pharmaceutical ingredients (APIs) demands a diverse array of coupling chemistries to achieve optimal activity and selectivity from available starting materials. Biaryl phosphorinane ligands have proven their versatility in a wide range of cross-coupling reactions, necessitating their production on a multi-kilogram scale. As such, a sophisticated multi-stage flow reaction was developed, optimized, and transitioned from small scale to multi-kilogram scale in the AbbVie Chemical Pilot Plant. This presentation will explore the complexities and nuances of employing various flow configurations in the process.
Bio:
Anna Bay is a Senior Scientist I in the Process Chemistry group at AbbVie, where she has been for 2.5 years. As part of the Innovative Chemical Technologies group and the Center for Reaction Engineering, she focuses on developing and advancing new technology platforms. Her academic journey began with a Bachelor of Arts in Chemistry from the College of Wooster, followed by a Ph.D. in Organic Chemistry from Northwestern University under the mentorship of Professor Karl Scheidt. There, she pioneered methods that synergize photoredox and carbene catalysis. Anna is actively involved in promoting diversity and safety in the chemical sciences through her leadership in the Process Chemistry Diversity Committee and various other outreach initiatives.
Keywords: flow chemistry, process chemistry, scale up, catalysis