Publications: Heike Hofstetter

Skubi, K. L.; Swords, W. B.; Hofstetter, H.; Yoon, T. P., LED-NMR Monitoring of an Enantioselective Catalytic 2+2 Photocycloaddition. ChemPhotoChem 2020. 10.1002/cptc.202000094

Esselman, B. J.; Hofstetter, H.; Ellison, A. J.; Fry, C. G.; Hill, N. J., S(N)1, E1, and E2 Reactions of tert-Amyl Compounds: Improved Analysis Using Computational Chemistry and ASAP-HSQC NMR Spectroscopy. J. Chem. Educ. 2020, 97 (8), 2280-2285. 10.1021/acs.jchemed.0c00071

Yang, H.; Hofstetter, H.; Cavagnero, S., Fast-pulsing LED-enhanced NMR: A convenient and inexpensive approach to increase NMR sensitivity. J. Chem. Phys. 2019, 151 (24), 245102. 10.1063/1.5131452

Hofstetter, O.; Hofstetter, H.; Miron, T.; Wilchek, M., The conversion of azo-quenchers to fluorophores. Analytical Biochemistry 2019, 585, 113400
. 10.1016/j.ab.2019.113400

De Bruyn, M.; Budarin, V. L.; Misefari, A.; Shimizu, S.; Fish, H.; Cockett, M.; Hunt, A. J.; Hofstetter, H.; Weckhuysen, B. M.; Clark, J. H.; Macquarrie, D. J., Geminal Diol of Dihydrolevoglucosenone as a Switchable Hydrotrope: A Continuum of Green Nanostructured Solvents. ACS Sustainable Chemistry & Engineering 2019, 7 (8), 7878-7883. 10.1021/acssuschemeng.9b00470

Van den Brande, N.; Gujral, A.; Huang, C. B.; Bagchi, K.; Hofstetter, H.; Yu, L.; Ediger, M. D., Glass Structure Controls Crystal Polymorph Selection in Vapor-Deposited Films of 4,4 ‘-Bis(N-carbazolyI)-1,1 ‘-biphenyl. Crystal Growth & Design 2018, 18 (10), 5800-5807. 10.1021/acs.cgd.8b00329

Ehrl, B. N.; Mogusu, E. O.; Kim, K.; Hofstetter, H.; Pedersen, J. A.; Elsner, M., High Permeation Rates in Liposome Systems Explain Rapid Glyphosate Biodegradation Associated with Strong Isotope Fractionation. Environ. Sci. Technol 2018, 52 (13), 7259-7268. 10.1021/acs.est.8b01004

Fry, C. G.; Hofstetter, H.; Bowman, M. D., A First Laboratory Utilizing NMR for Undergraduate Education: Characterization of Edible Fats and Oils by Quantitative C-13 NMR. J. Chem. Educ. 2017, 94 (9), 1319-1323. 10.1021/acs.jchemed.7b00057

Davenport, K. R.; Smiths, C. A.; Hofstetter, H.; Horn, J. R.; Hofstetter, O., Site-directed immobilization of a genetically engineered anti-methotrexate antibody via an enzymatically introduced biotin label significantly increases the binding capacity of immunoaffinity columns. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2016, 1021, 114-121. 10.1016/j.jchromb.2016.01.021

Eleniste, P. P.; Hofstetter, H.; Hofstetter, O., Expression and characterization of an enantioselective antigen-binding fragment directed against alpha-amino acids. Protein Expr. Purif. 2013, 91 (1), 20-29. 10.1016/j.pep.2013.06.010

Kassa, T.; Undesser, L. P.; Hofstetter, H.; Hofstetter, O., Antibody-based multiplex analysis of structurally closely related chiral molecules. Analyst 2011, 136 (6), 1113-1115. 10.1039/c0an00814a

Franco, E. J.; Sonneson, G. J.; DeLegge, T. J.; Hofstetter, H.; Horn, J. R.; Hofstetter, O., Production and characterization of a genetically engineered anti-caffeine camelid antibody and its use in immunoaffinity chromatography. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2010, 878 (2), 177-186. 10.1016/j.jchromb.2009.06.017

Ranieri, D. I.; Hofstetter, H.; Hofstetter, O., Computational structural analysis of an anti-L-amino acid antibody and inversion of its stereoselectivity. Journal of Separation Science 2009, 32 (10), 1686-1695. 10.1002/jssc.200800694

Franco, E. J.; Hofstetter, H.; Hofstetter, O., Determination of lactic acid enantiomers in human urine by high-performance immunoaffinity LC-MS. Journal of Pharmaceutical and Biomedical Analysis 2009, 49 (4), 1088-1091. 10.1016/j.jpba.2009.01.033

Zheng, C.; Hofstetter, H.; Hofstetter, O., Charge density and computational study of benzhydrol and benzhydrol-d(10). J. Mol. Struct. 2008, 875 (1-3), 173-182. 10.1016/j.molstruc.2007.04.034

Ranieri, D. I.; Corgliano, D. M.; Franco, E. J.; Hofstetter, H.; Hofstetter, O., Investigation of the stereoselectivity of an anti-amino acid antibody using molecular modeling and ligand docking. Chirality 2008, 20 (3-4), 559-570. 10.1002/chir.20522

Franco, E. J.; Hofstetter, H.; Hofstetter, O., Enantiomer separation of alpha-hydroxy acids in high-performance immunoaffinity chromatography. Journal of Pharmaceutical and Biomedical Analysis 2008, 46 (5), 907-913. 10.1016/j.jpba.2007.10.004

Bose, R. N.; Maurmann, L.; Mishur, R. J.; Yasui, L.; Gupta, S.; Grayburn, W. S.; Hofstetter, H.; Milton, T., Non-DNA-binding platinum anticancer agents: Cytotoxic activities of platinum-phosphato complexes towards human ovarian cancer cells. Proc. Natl. Acad. Sci. U. S. A. 2008, 105 (47), 18314-18319. 10.1073/pnas.0803094105

Zeleke, J. M.; Smith, G. B.; Hofstetter, H.; Hofstetter, O., Enantiomer separation of amino acids in immunoaffinity micro LC-MS. Chirality 2006, 18 (7), 544-550. 10.1002/chir.20286

Franco, E. J.; Hofstetter, H.; Hofstetter, O., A comparative evaluation of random and site-specific immobilization techniques for the preparation of antibody-based chiral stationary phases. Journal of Separation Science 2006, 29 (10), 1458-1469. 10.1002/jssc.200600062

Zeleke, T. K.; Zeleke, J. M.; Hofstetter, H.; Hofstetter, O., Stereoselective antibodies to free alpha-hydroxy acids. Journal of Molecular Recognition 2005, 18 (4), 334-340. 10.1002/jmr.741

Hofstetter, O.; Hertweck, J. K.; Hofstetter, H., Detection of enantiomeric impurities in a simple membrane-based optical immunosensor. Journal of Biochemical and Biophysical Methods 2005, 63 (2), 91-99. 10.1016/j.jbbm.2005.03.003

Hofstetter, H.; Hofstetter, O., Antibodies as tailor-made chiral selectors for detection and separation of stereoisomers. TrAC-Trends in Analytical Chemistry 2005, 24 (10), 869-879. 10.1016/j.trac.2005.04.018

Hofstetter, H.; Hofstetter, O., Antibodies as Tailor-made Chiral Selectors: An Interdisciplinary Approach to Enantiomer Separation and Detection. Chinese Journal of Chromatography 2005, 23 (5), 508-519.

Hofstetter, H.; Cary, J. R.; Eleniste, P. P.; Hertweck, J. K.; Lindstrom, H. J.; Ranieri, D. I.; Smith, G. B.; Undesser, L. P.; Zeleke, J. M.; Zeleke, T. K.; Hofstetter, O., New developments in the production and use of stereoselective antibodies. Chirality 2005, 17, S9-S18. 10.1002/chir.20099

Tsourkas, A.; Hofstetter, O.; Hofstetter, H.; Weissleder, R.; Josephson, L., Magnetic relaxation switch immunosensors detect enantiomeric impurities. Angew. Chem.-Int. Edit 2004, 43 (18), 2395-2399. 10.1002/anie.200352998

Hofstetter, O.; Lindstrom, H.; Hofstetter, H., Effect of the mobile phase on antibody-based enantiomer separations of amino acids in high-performance liquid chromatography. J. Chromatogr. A 2004, 1049 (1-2), 85-95. 10.1016/j.chroma.2004.08.002

Dutta, P.; Tipple, C. A.; Lavrik, N. V.; Datskos, P. G.; Hofstetter, H.; Hofstetter, O.; Sepaniak, M. J., Enantioselective sensors based on antibody-mediated nanomechanics. Anal. Chem. 2003, 75 (10), 2342-2348. 10.1021/ac034031z

Hofstetter, O.; Lindstrom, H.; Hofstetter, H., Direct resolution of enantiomers in high-performance immunoaffinity chromatography under isocratic conditions. Anal. Chem. 2002, 74 (9), 2119-2125. 10.1021/ac0157369

Wilchek, M.; Hofstetter, H.; Hofstetter, O., The Application of Biorecognition. In Novel Approaches in Biosensors and Rapid Diagnostic Assays, Liron, Z.; Bromberg, A.; Fisher, M., Eds. Kluwer Academic/Plenum Publishers: New York, NY, 2001; pp 173-191. 10.1007/978-1-4615-1231-8_13

Hofstetter, O.; Hofstetter, H., Antibodies as chiral selectors for the determination of enantioenrichment. Enantiomer 2001, 6 (2-3), 153-158.

Hofstetter, O.; Hofstetter, H.; Wilchek, M.; Schurig, V.; Green, B. S., An immunochemical approach for the determination of trace amounts of enantiomeric impurities. Chemical Communications 2000, (17), 1581-1582. 10.1039/b004587j

Hofstetter, O.; Hofstetter, H.; Wilchek, M.; Schurig, V.; Green, B. S., Production and applications of antibodies directed against the chiral center of alpha-amino acids. International Journal of Bio-Chromatography 2000, 5 (3), 165-174.

Hofstetter, H.; Morpurgo, M.; Hofstetter, O.; Bayer, E. A.; Wilchek, M., A labeling, detection, and purification system based on 4-hydroxyazobenzene-2-carboxylic acid: An extension of the avidin-biotin system. Analytical Biochemistry 2000, 284 (2), 354-366. 10.1006/abio.2000.4617

Hofstetter, O.; Hofstetter, H.; Wilchek, M.; Schurig, V.; Green, B. S., Chiral discrimination using an immunosensor. Nature Biotechnology 1999, 17 (4), 371-374. 10.1038/7927

Morpurgo, M.; Hofstetter, H.; Bayer, E. A.; Wilchek, M., A chemical approach to illustrate the principle of signal transduction cascades using the avidin-biotin system. Journal of the American Chemical Society 1998, 120 (49), 12734-12739. 10.1021/ja982817m

Hofstetter, O.; Hofstetter, H.; Schurig, V.; Wilchek, M.; Green, B. S., Antibodies can recognize the chiral center of free alpha-amino acids. Journal of the American Chemical Society 1998, 120 (13), 3251-3252. 10.1021/ja973680n

Hofstetter, H.; Hofstetter, O.; Schurig, V., Enantiomer separation using BSA as chiral stationary phase in affinity OTEC and OTLC. J. Microcolumn Sep. 1998, 10 (3), 287-291. 10.1002/(sici)1520-667x(1998)10:3<287::Aid-mcs8>3.0.Co;2-c

Hofstetter, O.; Hofstetter, H.; Then, D.; Schurig, V.; Green, B. S., Direct binding of low molecular weight haptens to ELISA plates. J. Immunol. Methods 1997, 210 (1), 89-92. 10.1016/s0022-1759(97)00180-4

Hofstetter, H.; Hofstetter, O.; Schurig, V., Rapid separation of enantiomers in perfusion chromatography using a protein chiral stationary phase. J. Chromatogr. A 1997, 764 (1), 35-41. 10.1016/s0021-9673(96)00936-3

Jung, G.; Hofstetter, H.; Feiertag, S.; Stoll, D.; Hofstetter, O.; Wiesmuller, K. H.; Schurig, V., Cyclopeptide libraries as new chiral selectors in capillary electrophoresis. Angewandte Chemie-International Edition in English 1996, 35 (18), 2148-2150. 10.1002/anie.199621481

Hofstetter, H.; Hofstetter, O.; Wistuba, D., Chiral interaction of a polyclonal anti-dinitrophenyl antibody with dinitrophenyl amino acids determined by an enantioselective enzyme-linked immunosorbent assay. Anal. Chim. Acta 1996, 332 (2-3), 285-290. 10.1016/0003-2670(96)00249-8

Wistuba, D.; Diebold, H.; Schurig, V., Enantiomer separation of DNP‐amino acids by capillary electrophoresis using chiral buffer additives. J. Microcolumn Sep. 1995, 7 (1), 17-22. 10.1002/mcs.1220070103