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Organic Chemistry Seminar-Prof. Alois Fürstner, Max-Planck-Gesellschaft
November 8, 2021 @ 11:00 am - 12:00 pm
Prof. Alois Fürstner
Organic, Stork Lecture, Special Seminar
MERRY-GO-ROUND: ALKENES, ALKYNES, ALKYLIDENES, ALKYLIDENES
This lecture intends to showcase some unconventional ways of harnessing the reactivity of alkynes via highly selective metal-catalyzed transformations. After a review of our work in the area of triple bond metathesis, some unorthodox addition reactions to internal alkynes will be discussed, including metal catalyzed trans-hydrogenation, trans-hydroboration, trans-hydrostannation and trans-hydro(chloro)alkynylation, which have little precedent in the literature, if any.
Even more perplexing is the ability to transfer both H-atoms of H2 to one and the same C-atom of a triple bond with concomitant formation of a discrete metal carbene at the adjacent position (“gem-hydrogenation”). This entirely new reactivity mode unlocks numerous opportunities for organic synthesis and organometallic chemistry alike, which we have started to explore.
The underlying mechanisms will be discussed in some detail; selected applications to target-oriented synthesis are meant to showcase the current state of development
FOR MORE INFORMATION. PLEASE CONTACT: MARY HANDSON AT MCHANSO1@WISC.EDU OR
ALISA GRADNEY AT AGRADNEY@WISC.EDU