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Organic Chemistry Seminar-Prof. Alois Fürstner, Max-Planck-Gesellschaft

November 9, 2021 @ 10:30 am - 11:30 am

Event Presenter:

Prof. Alois Fürstner

Institution:

Max-Planck-Gesellschaft

Categories:

Organic, Stork Lecture, Special Seminar

PI-ACID CATALYSIS: CONCEPTS AND APPLICATIONS

Man with glasses in red turtleneck and sweater

It was only shortly before the turn of the millennium that the advantages of homogeneous catalysts based on platinum or gold started to capture the imagination of synthetic chemists. In this context, our group proposed in 1998 for the first time that certain transformations catalyzed by these carbophilic Lewis acids might involve “metal carbenoids” as the key intermediates. This mechanistic proposal had predictive power and guided our work in this area over the following years. Specifically, we were able to isolate the first reactive gold carbene and thus gain important insights into structure and bonding. At the same time, our growing confidence in the maturity of this type of catalysis encouraged us to pursue increasingly challenging applications to heterocyclic chemistry and natural product synthesis.

The second part of this seminar will deal with rhodium carbenes formed by reaction of diazo derivatives with (chiral) dirhodium or bismuth/rhodium tetracarboxylate salts. Over the last four decades, these “superelectrophilic” species gained tremendous importance in (asymmetric) catalysis but largely defied direct inspection. Our group managed to isolate a set of representative complexes of this type, which could even be characterized by crystallographic means. The data allow empirical trends in ligand design to be rationalized and provide a sound basis for further advances in the field .

Stork – Prof. Fürstner 11.9 Seminar Poster

FOR MORE INFORMATION. PLEASE CONTACT: MARY HANDSON AT MCHANSO1@WISC.EDU OR

ALISA GRADNEY AT AGRADNEY@WISC.EDU

Details

Date:
November 9, 2021
Time:
10:30 am - 11:30 am
Event Category:

Organizer

Prof. Zach Wickens

Other

Meeting Type
Virtual