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McElvain Lecture: Organic Chemistry Seminar – Prof. Eric Jacobsen, Harvard University

February 23 @ 3:30 pm - 4:30 pm

Event Presenter:

Prof. Eric Jacobsen

Institution:

Harvard University

Categories

Organic Chemistry, Seminar

PRIVILEGED CHIRAL CATALYSTS

Man with white hair and beard smilingAbstract Privileged chiral scaffolds—structures that have been demonstrated to induce high levels of enantioselectivity across a variety of mechanistically distinct reactions—have proven profoundly enabling to the discovery of new asymmetric catalytic reactions. This lecture will outline the development of a specific, new class of privileged chiral catalysts: dual H-bond donors (HBDs) bearing aryl-pyrrolidino-tert-leucine motifs. These HBD catalysts have proven broadly useful in a variety of C–C and C–heteroatom bond-forming processes, with enantioselectivity dictated primarily through selective stabilizing non-covalent interactions. Detailed case studies on the mechanism of enantioinduction with aryl-pyrrolidino-tert-leucine HBDs will be presented, highlighting the cooperative features of these simple organic molecules that are likely responsible for the privileged nature of this scaffold.

FOR MORE INFORMATION, CONTACT: ALISA GRADNEY AT AGRADNEY@WISC.EDU

Seminar Poster Jacobsen, Eric

Details

Date:
February 23
Time:
3:30 pm - 4:30 pm
Event Categories:
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