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Chemical Biology Seminar-Prof. Jeff Chan, University of Illinois, Urbana-Champaign
September 21 @ 3:30 pm - 4:30 pm
Prof. Jeff Chan
University of Illinois, Urbana-Champaign
Chemical Biology, Seminar
DESIGN, SYNTHESIS, AND APPLICATION OF CHEMICAL PROBES FOR IN VIVO IMAGING OF DISEASE BIOMARKERS
Many disease states are characterized by molecular level changes that occur before detectable symptoms have begun to manifest. In order to maximize treatment outcomes, it is essential to accurately detect such alterations at an early stage. Chemical probes designed to selectively image such molecular processes have the potential to not only aid in disease diagnosis but can also provide unique insights into disease progression. As an important step toward these goals, we have developed a palette of activatable probes for photoacoustic imaging and apply these to visualize changes in the tumor microenvironment. Our design approach employs the principles of activity-based sensing (ABS), which is distinct from traditional binding-based probes in that they leverage the unique chemical reactivity of an analyte for sensing. Depending on the intended application, it is possible to accelerate or attenuate reactivity to detect fleeting analytes or high abundance targets, respectively. Moreover, when coupled to a photoacoustic readout, molecular features that would otherwise be elusive can be visualized with high resolution within a native tissue environment. In this regard, photoacoustic imaging is a state-of-the-art technique that generates ultrasound signals from light. Since sound scattering is three orders of magnitude less than light in tissue, photoacoustic imaging can be employed to image up to 12 cm in depth while achieving micron resolution. In this seminar, we will discuss the strategies employed to construct these specialized imaging probes, as well as highlight recent applications from our laboratory.
FOR MORE INFORMATION, CONTACT:
ALISA GRADNEY AT AGRADNEY@WISC.EDU