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AbbVie Organic Seminar – Prof. Todd Hyster, Cornell University

March 1 @ 3:30 pm - 4:30 pm

Event Presenter:

Prof. Todd Hyster

Institution:

Cornell University

Categories:

Organic, AbbVie Seminar, Special Seminar

PHOTOENZYMATIC CATALYSIS – USING LIGHT TO REVEAL NEW ENZYME FUNCTIONS

Man in red shirtEnzymes are exquisite catalysts for chemical synthesis, capable of providing unparalleled levels of chemo-, regio-, diastereo- and enantioselectivity. Unfortunately, biocatalysts are often limited to the reactivity patterns found in nature. In this talk, I will share my groups efforts to use light to expand the reactivity profile of enzymes. In our studies, we have exploited the photoexcited state of common biological cofactors, such as NADH and FMN to facilitate electron transfer to substrates bound within enzyme active sites. In other studies, we found that enzymes will electronically activate bound substrates for electron transfer. In the presence of common photoredox catalysts, this activation can be used to direct radical formation to enzyme active sites. Using these approaches, we are able to develop biocatalysts to solve long-standing selectivity challenges in chemical synthesis.

AbbVie Seminar Poster

FOR MORE INFORMATION. PLEASE CONTACT: MARY HANDSON AT MCHANSO1@WISC.EDU OR

ALISA GRADNEY AT AGRADNEY@WISC.EDU

Details

Date:
March 1
Time:
3:30 pm - 4:30 pm
Event Categories:
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