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AbbVie Organic Seminar – Prof. Todd Hyster, Cornell University
March 1 @ 3:30 pm - 4:30 pm
Prof. Todd Hyster
Organic, AbbVie Seminar, Special Seminar
PHOTOENZYMATIC CATALYSIS – USING LIGHT TO REVEAL NEW ENZYME FUNCTIONS
Enzymes are exquisite catalysts for chemical synthesis, capable of providing unparalleled levels of chemo-, regio-, diastereo- and enantioselectivity. Unfortunately, biocatalysts are often limited to the reactivity patterns found in nature. In this talk, I will share my groups efforts to use light to expand the reactivity profile of enzymes. In our studies, we have exploited the photoexcited state of common biological cofactors, such as NADH and FMN to facilitate electron transfer to substrates bound within enzyme active sites. In other studies, we found that enzymes will electronically activate bound substrates for electron transfer. In the presence of common photoredox catalysts, this activation can be used to direct radical formation to enzyme active sites. Using these approaches, we are able to develop biocatalysts to solve long-standing selectivity challenges in chemical synthesis.
FOR MORE INFORMATION. PLEASE CONTACT: MARY HANDSON AT MCHANSO1@WISC.EDU OR
ALISA GRADNEY AT AGRADNEY@WISC.EDU