 Professor
B.S., B.A. 1994 University of Rochester
Ph.D. 1999, University of California, Berkeley
Room: 8305I
Phone: 608-262-4783
Email: zanni@chem.wisc.edu
Position: Professor
Moran S.D., Woys A.M., Buchanan L.E., Bixby E., Decatur S.M., Zanni, M.T., “Two-dimensional IR spectroscopy and segmental 13C labeling reveals the domain structure of human gD-crystallin amyloid fibrils,” PNAS, In Press. Xiong, W., Laaser J.E., Mehlenbacher R.D., Zanni M.T. “Adding a dimension to the infrared spectra of interfaces using heterodyne detected 2D sum-frequency generation (HD 2D SFG) spectroscopy,” PNAS, 108, 20902 (2011). Middleton, C.T., Buchanan, L.E., Dunkelberger, E., Zanni, M.T., “Utilizing lifetimes to suppress random coil features in 2D IR spectra of peptides,” JPC Letters, 2, 2357, 2011. PMCID: PMC3182477. Wang, L., Middleton, C.T, Singh, S., Reddy, A., Woys, A.M., Strasfeld, D.B., Marek, P., Raleigh, D.P.; de Pablo, J.J., Zanni, M.T., Skinner, J.L., “2DIR Spectroscopy of Human Amylin Fibrils Reflects Stable β-sheet Structure,” JACS, 133, 16062 (2011). PMCID: PMC3196637 Laaser, J. E., Xiong, W. and Zanni, M.T. "Time-domain SFG spectroscopy using mid-IR pulse shaping: Practical and intrinsic advantages,” J. Phys. Chem. B, 115, 2536-2546 (2011). Woys, A.M., Lin, Y.-S., Reddy, A.S., Xiong, W., de Pablo, J.J., Skinner, J.L., Zanni, M.T., "2D IR line shapes probe ovispirin peptide conformation and depth in lipid bilayers", J. Amer. Chem. Soc., 132, 2832 (2010). Xiong, W., Laaser, J.E., Paoprasert, P., Franking, R., Hamers, R.J., Gopalan, P., Zanni, M.T., “Transient 2D IR spectroscopy of charge injection in dye-sensitized nanocrystalline thin films,” J. Amer. Chem. Soc., 131, 18040 (2009).
| Research Description
The Zanni group studies topics in biophysics and the energy sciences using 2D IR spectroscopy. We have research projects underway on carbon nanotube energy transfer, solar cell charge transfer, and the mechanism of protein aggregation in type 2 diabetes, to name only a few topics. We specialize in scientific problems in which structural dynamics and/or interfacial phenomena are important. Systems that have these characteristics are very difficult to study with more traditional structural methods, and so our techniques often provide some of the best available structural and dynamical information.
We are also very active in developing the technology behind multidimensional spectroscopies. These multidimensional spectroscopies include 2D IR spectroscopy, 2D sum-frequency generation spectroscopy, and (soon) 2D Vis spectroscopy. We develop new pulse sequences and new experimental methods for more easily and accurately collecting these spectra.
In tandem to our technological efforts, we also focus on adapting biochemical techniques to 2D IR spectroscopy, including protein expression, protein ligation and inorganic chemistry. For example, we have used expressed protein ligation to isotope label one of two domains in a lens protein. And we have synthesized inorganic probes of protein environment in analogy to EPR labels.
As a result of our wide ranging interests, students and postdoctoral researchers in our group obtain a range of experiences from technique development to synthesis or biosynthesis to topical applications. We also collaborate extensively with theorists, organic chemists and material scientists who are interested in simulating or using 2D IR spectroscopy for their research. Please see our website for more information.
H.I. Romnes Faculty Fellowship, UW-Madison, 2011 National Academy of Sciences Award for Initiatives in Research, 2011 Raymond and Beverly Sackler Prize in the Physical Sciences, 2011 ACS Nobel Laureate Signature Award for Graduate Education in Chemistry, 2010 NIDDK 60th Anniversary Early Career Investigatior/Scholar Award from NIH National Institute of Diabetes and Digestive Kidney Disease. 2010 Fellow of the American Physical Society, 2010 Presidential Early Career Award for Scientists and Engineers (PECASE), 2009 Coblentz Award, 2006 Alfred P. Sloan Research Fellow, 2006 Benjamin Smith Reynolds Award for Excellence in Teaching Engineers, 2005 Packard Foundation Science and Engineering Fellowship, 2005 Beckman Young Investigators Award, 2004 National Science Foundation CAREER Award, 2003 Research Corporation Innovation Award, 2002 Camille and Henry Dreyfus New Faculty Award, 2002 American Chemical Society Nobel Laureate Signature Award for Graduate Education in Chemistry, 2001 National Institute of Health Postdoctoral Fellow (NRSA), 2000 American Chemical Society Regional Award, Rochester, NY, 1994 - Bausch and Lomb Scholar, University of Rochester, 1990
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