Robert C. West

Emeritus Professor, Born 1928

- B.A.,1950, Cornell University; A.M.,1952, Ph. D. 1954, Harvard University
- Assistant Professor, University of Wisconsin-Madison,1957 62
- Associate Professor, University of Wisconsin-Madison, 1962 63.  
- Professor, University of Wisconsin-Madison, 1963 80;
- Eugene G. Rochow Professor, University of Wisconsin-Madison, 1980 present
- Director, Organosilicon Research Center, University of Wisconsin-Madison, 1999-¬present
- Founder & president, SILATRONIX Inc., 2007-present
- Distnguished Professor, Yonsei University, Wonju, Korea, 2009-2011

Room: 6329
Phone: 608-262-1873
Email: west@chem.wisc.edu
Position: Emeritus Professor

Research Description

Although Bob West is formally retired, he maintains an active research group studying various aspects of organosilicon chemistry.

Research in this group is mainly devoted to compounds of silicon and germanium. We synthesize new and unusual types of compounds, and study their chemical bonding usng electronic spectroscopy, X-ray crystallography, NMR, EPR and muon spin resonance spectroscopy. In addition we are synthesizing organosilicon compounds as electrolytes for batteries and ultracapacitors, and silicon-containing drug molecules, especially for use as anticancer drugs.

1. Silylenes and germylenes, R2Si: and R2Ge:. These compounds are the silicon and germanium counterparts to carbenes, R2C:, and like carbenes they are usually intensely reactive and unstable. In our group we synthesized the first stable silylenes, 1 and 2. 1 is a 6-pi electron molecule, stabilized by aromatic resonance.



These compounds have opened up a new area of silicon chemistry. For example, here are two reactions leading to new classes of compounds:



The silylenes and their metal complexes have catalytic activity, which is just being studied. We will be doing much more research to explore the chemistry of stable silylenes and their germanium and tin analogs.

2. Silicon-containing anticancer drugs. We are synthesizing analogs to known medicinal compounds, in which we introduce a silicon atom at a strategic point. The resulting substance has somewhat different properties from the original drug, and in some cases prove to be much more active. For example, addition of a silicon substitutent to the known antiinflammatory drug indomethacin, 3, produces “silamethacin”, 4 (n = 3, R = CH3). This sila-drug is much more selective and less toxic than 3. It also has highly promising anticancer activity, against pancreatic, ovarian and lung cancer cells. This and other sila-drugs from our laboratories are now being tested for their anticancer activity in mice. We are exploring many opportunities for silicon substitution into other drug molecules.



3. Polysiloxanes. In the polysiloxane polymers (silicones), the main chain consists of alternating silicon and oxygen atoms. The great flexibility of the silicon-oxygen bonds gives these polymers exceptional properties. The group has recently made polysiloxanes with oligo ethylene oxide side chains, which chelate to lithium ions and promote their transport through the polymer. For example:



Dicomb polysiloxanes of this type show the highest lithium ion conductivity yet recorded for a polymeric electrolyte. We have started a company, Silatronix Inc., to to develop new polysiloxane electrolytes for the next generation of high energy density batteries.

4. Muon spin resonance spectroscopy. Muons are antiparticles, present in cosmic rays. For experimentation they are generated in the proton beam of a cyclotron. Muons can bind to unsaturated molecules to create free radicals, in which they behave something like protons. They undergo decay with a lifetime of 2.2 microseconds, to form positrons which can be counted individually. In a magnetic field, this produces a muon spin resonance spectrum Muon spin resonance has been determined for organic molecules, but its application to organometallic molecues is almost unknown. Using the TRIUMF proton cyclotron in Vancouver BC, we have carried out the first muon spin resonance spectra for silicon and germanium centered radicals. Muon spin resonance spectroscopy is a new method for studying organometallic radicals, giving important structural and chemical bonding information To date we have observed muon spin resonance spectra for divalent compounds of Si and Ge (silylenes and germylenes) as well as a compound containing a Si=C double bond. We plan to study many other unsaturated compounds, first of the group 14 elements, and later for many other main group and transition metal organometallic compounds.
Last updated March 24, 2009

Publications

• Silicon-containing liquid polymer electrolytes for application in lithium ion batteries, N. A. A. Rossi, R West, Polymer International, in press

• Detection of a secondary muoniated radical, B. M. McCollum, J.-C. Brodovitch, Jason A. C. Clyburne, P. W. Percival, R. West,  Physica B , in press

• Muon Spin Resonance:  A New Spectroscopy for Organosilicon Compounds, R. West, Kagaku to Kogyo, 61, 1059-1061 (2008)

• The synthesis and characterization of three new N-hereocyclic germylenes, A. C. Tomasik, N. J. Hill, R. West, J. Organometal. Chem. 28, 378-380 (2009).

• "Novel Aromatic Species Containing Group 14 Atoms", R. West, Pure Appl. Chem., 80, 80, 563 (2008).

• The Synthesis and Reactivity of Three New N-Hetrocyclic Silylenes, A. C.Tomasik, A. Mitra, R. West,
  Organometallics 28, 378-381 (2008).

• Probing the reactivity of a stable silene using muonium,  B. M. McCollum, T. Abe, J.-C Brodovitch, J. A. C. Clyburne, T. Iwamoto, M. Kira, P. w. Percival, R. West, Angew. Chem., 50, 9772-4 (2008).

• Highly Conductive Trimethylsilyl Oligo(Ethylene Oxide) Electrolytes for Energy Storage Applications, L. Zhang, Z. Zhang, S. Harring, M. Straughan, R. Butorac, L. Lyons, Z. Chen, K. Amine, R. West, J. Materials Chem.2008, 18, 3713 – 3717.

• Gel electrolyte for lithium-ion batteries. Chen, Z.; Zhang, L. Z.; West, R.; Amine, K.     Electrochimica Acta  (2008),  53(8),  3262-3266.

• Silylene and Germylene Intermediates in the Reactions of Silole and Germole Dianions with N,N’-di-tert-butylethylenediamine, I. S. Toulokhonova, V. I Timokhin, D. N. Bunck, T. Mueller, I Guzei, R. West, Eur. J. Inorg. Chem., 2344-2349 (2008).

Awards

• WCU Distinguished Professor, Yonsei University, 2009

• Honorary Member of Japan Chemical Society, 2007

• World Innovation Foundation Fellow, 2005

• Chemical Society of Japan Award, 2005

• Research & Development 100 Award for Technical Innovation, 2005

• Listed as Highly-cited Chemist for 1981 - 1989, 2003

• Main Group Chemistry Medal, 2003

• James W. Taylor Excellence in Teaching Award, 2002

• Honorary Doctor of Science Degree, G. Asachi Technical University of Romania, 1995

• Humboldt Research Award, 1989 and 2002