Martha M. Vestling

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Dir Mass Spec Labs - CIC

A.B. 1962, Oberlin College
Ph.D. 1967, Northwestern University
Postdoctoral Fellow, University of Florida, Gainesville

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Research Description

As director of the Chemistry Department’s Mass Spectrometry Laboratory (a shared-instrument facility), my task is to train interested students and postdoctoral fellows how to obtain data and to generate data for everybody else. The challenge is to get molecules into the gas phase as ions. The Chemistry Department synthesizes and isolates all sorts of molecules, such as small organics, lipids, carbohydrates, organometallics, metal complexes, peptides, artificial peptides, isotopically labeled compounds, proteins and polymers. Since no single mass spectrometer can handle all types of molecules, the Laboratory has and needs a variety of ionization methods and analyzers. The main ionization methods available are EI (electron impact), ESI (electrospray ionization) and MALDI (matrix-assisted laser desorption/ionization). For more information, see the Mass Spectrometry facility website

Selected Publications

Feliciano RP, Heintz JA, Krueger CG, Vestling MM, Reed JD. Fluorescent labeling of cranberry proanthocyanidins with 5-( 4,6-dichlorotriazin-2-yl amino)fluorescein (DTAF). Food Chemistry. 2015;166:337-345.
Konop CJ, Knickelbine JJ, Sygulla MS, Vestling MM, Stretton AOW. Different Neuropeptides Are Expressed in Different Functional Subsets of Cholinergic Excitatory Motorneurons in the Nematode Ascaris suum. ACS Chemical Neuroscience. 2015;6:855-870.
Konop CJ, Knickelbine JJ, Sygulla MS, Wruck CD, Vestling MM, Stretton AOW. Mass Spectrometry of Single GABAergic Somatic Motorneurons Identifies a Novel Inhibitory Peptide, As-NLP-22, in the Nematode Ascaris suum. Journal of the American Society for Mass Spectrometry. 2015;26:2009-2023.
Jarecki JL, Viola IR, Andersen KM, Miller AH, Ramaker MA, Vestling MM, et al.. Three independent techniques localize expression of transcript afp-11 and its bioactive peptide products to the paired AVK neurons in Ascaris suum: In situ hybrization, immunocytochemistry, and single cell mass spectrometry. ACS Chemical Neuroscience. 2013;.
Feliciano RP, Krueger CG, Shanmuganayagam D, Vestling MM, Reed JD. Deconvolution of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry isotope patterns to determine ratios of A-type to B-type interflavan bonds in cranberry proanthocyanidins. Food Chemistry. 2012;135:1485-1493.