Publications

Vasquez JK, Tal-Gan Y, Cornilescu G, Tyler KA, Blackwell HE. Simplified AIP-II Peptidomimetics Are Potent Inhibitors of Staphylococcus aureus AgrC Quorum Sensing Receptors. Chembiochem. 2017;18:413-423.
Kratochvil MJ, Yang T, Blackwell HE, Lynn DM. Nonwoven Polymer Nanofiber Coatings That Inhibit Quorum Sensing in Staphylococcus aureus: Toward New Nonbactericidal Approaches to Infection Control. Acs Infectious Diseases. 2017;3:271-280.
Tal-Gan Y, Ivancic M, Cornilescu G, Blackwell HE. Characterization of structural elements in native autoinducing peptides and non-native analogues that permit the differential modulation of AgrC-type quorum sensing receptors in Staphylococcus aureus. Organic & Biomolecular Chemistry. 2016;14:113-121.
O'Reilly MC, Blackwell HE. Structure-Based Design and Biological Evaluation of Triphenyl Scaffold-Based Hybrid Compounds as Hydrolytically Stable Modulators of a LuxR-Type Quorum Sensing Receptor. Acs Infectious Diseases. 2016;2:32-38.
Manna U, Raman N, Welsh MA, Zayas-Gonzalez YM, Blackwell HE, Palecek SP, et al.. Slippery Liquid-Infused Porous Surfaces that Prevent Microbial Surface Fouling and Kill Non-Adherent Pathogens in Surrounding Media: A Controlled Release Approach. Advanced Functional Materials. 2016;26:3599-3611.
Kratochvil MJ, Welsh MA, Manna U, Ortiz BJ, Blackwell HE, Lynn DM. Slippery Liquid-Infused Porous Surfaces that Prevent Bacterial Surface Fouling and Inhibit Virulence Phenotypes in Surrounding Planktonic Cells. Acs Infectious Diseases. 2016;2:509-517.
Yang T, Tal-Gan Y, Paharik AE, Horswill AR, Blackwell HE. Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation. ACS Chemical Biology. 2016;11:1982-1991.
Welsh MA, Blackwell HE. Chemical Genetics Reveals Environment-Specific Roles for Quorum Sensing Circuits in Pseudomonas aeruginosa. Cell Chemical Biology. 2016;23:361-369.
Tal-Gan Y, Ivancic M, Cornilescu G, Yang T, Blackwell HE. Highly Stable, Amide-Bridged Autoinducing Peptide Analogues that Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureus. Angewandte Chemie-International Edition. 2016;55:8913-8917.
Patel NM, Moore JD, Blackwell HE, Amador-Noguez D. Identification of Unanticipatedand Novel N-Acyl L-Homoserine Lactones (AHLs) Using a Sensitive Non-Targeted LC-MS/MS Method. Plos One. 2016;11.
Welsh MA, Blackwell HE. Chemical probes of quorum sensing: from compound development to biological discovery. FEMS Microbiology Reviews. 2016;40:774-794.
Palmer AG, Mukherjee A, Stacy DM, Lazar S, Ane JM, Blackwell HE. Interkingdom Responses to Bacterial Quorum Sensing Signals Regulate Frequency and Rate of Nodulation in Legume-Rhizobia Symbiosis. Chembiochem. 2016;17:2199-2205.
Gerdt JP, McInnis CE, Schell TL, Blackwell HE. Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR. Organic & Biomolecular Chemistry. 2015;13:1453-1462.
Welsh MA, Eibergen NR, Moore JD, Blackwell HE. Small Molecule Disruption of Quorum Sensing Cross-Regulation in Pseudomonas aeruginosa Causes Major and Unexpected Alterations to Virulence Phenotypes. Journal of the American Chemical Society. 2015;137:1510-1519.
Moore JD, Rossi FM, Welsh MA, Nyffeler KE, Blackwell HE. A Comparative Analysis of Synthetic Quorum Sensing Modulators in Pseudomonas aeruginosa: New Insights into Mechanism, Active Efflux Susceptibility, Phenotypic Response, and Next-Generation Ligand Design. Journal of the American Chemical Society. 2015;137:14626-14639.
Kratochvil MJ, Tal-Gan Y, Yang T, Blackwell HE, Lynn DM. Nanoporous Superhydrophobic Coatings that Promote the Extended Release of Water-Labile Quorum Sensing Inhibitors and Enable Long-Term Modulation of Quorum Sensing in Staphylococcus aureus. ACS Biomater. Sci. Eng. 2015;1:1039-1049.
Tal-Gan Y, Stacy DM, Blackwell HE. N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus. Chemical Communications. 2014;50:3000-3003.
Moore JD, Gerdt JP, Eibergen NR, Blackwell HE. Active Efflux Influences the Potency of Quorum Sensing Inhibitors in Pseudomonas aeruginosa. Chembiochem. 2014;15:435-442.
McInnis CE, Blackwell HE. Non-native N-Aroyl (L)-Homoserine Lactones Are Potent Modulators of the Quorum Sensing Receptor RpaR in Rhodopseudomonas palustris. Chembiochem. 2014;15:87-93.
Studer SV, Schwartzman JA, Ho JS, Geske GD, Blackwell HE, Ruby EG. Non-native acylated homoserine lactones reveal that LuxIR quorum sensing promotes symbiont stability. Environmental Microbiology. 2014;16:2623-2634.
Palmer AG, Senechal AC, Mukherjee A, Ane JM, Blackwell HE. Plant Responses to Bacterial N-Acyl L-Homoserine Lactones are Dependent on Enzymatic Degradation to L-Homoserine. ACS Chemical Biology. 2014;9:1834-1845.
Gerdt JP, Blackwell HE. Competition Studies Confirm Two Major Barriers That Can Preclude the Spread of Resistance to Quorum-Sensing Inhibitors in Bacteria. ACS Chemical Biology. 2014;9:2291-2299.
Broderick AH, Stacy DM, Tal-Gan Y, Kratochvil MJ, Blackwell HE, Lynn DM. Surface Coatings that Promote Rapid Release of Peptide-Based AgrC Inhibitors for Attenuation of Quorum Sensing in Staphylococcus aureus. Adv. Healthcare Mater. 2014;3:97-105.
Gerdt JP, McInnis CE, Schell TL, Rossi FM, Blackwell HE. Mutational Analysis of the Quorum-Sensing Receptor LasR Reveals Interactions that Govern Activation and Inhibition by Nonlactone Ligands. Chemistry & Biology. 2014;21:1361-1369.
Tal-Gan Y, Stacy DM, Foegen MK, Koenig DW, Blackwell HE. Highly Potent Inhibitors of Quorum Sensing in Staphylococcus aureus Revealed Through a Systematic Synthetic Study of the Group-III Autoinducing Peptide. Journal of the American Chemical Society. 2013;135:7869-7882.
Tal-Gan Y, Ivancic M, Cornilescu G, Cornilescu CC, Blackwell HE. Structural Characterization of Native Autoinducing Peptides and Abiotic Analogues Reveals Key Features Essential for Activation and Inhibition of an AgrC Quorum Sensing Receptor in Staphylococcus aureus. Journal of the American Chemical Society. 2013;135:18436-18444.
Stacy DM, Le Quement ST, Hansen CL, Clausen JW, Tolker-Nielsen T, Brummond JW, et al.. Synthesis and biological evaluation of triazole-containing N-acyl homoserine lactones as quorum sensing modulators. Organic & Biomolecular Chemistry. 2013;11:938-954.
Crapster JA, Guzei IA, Blackwell HE. A Peptoid Ribbon Secondary Structure. Angewandte Chemie-International Edition. 2013;52:5079-5084.
Broderick AH, Breitbach AS, Frei R, Blackwell HE, Lynn DM. Surface-Mediated Release of a Small-Molecule Modulator of Bacterial Biofilm Formation: A Non-Bactericidal Approach to Inhibiting Biofilm Formation in Pseudomonas aeruginosa. Adv. Healthcare Mater. 2013;2:993-1000.
Stacy DM, Welsh MA, Rather PN, Blackwell HE. Attenuation of Quorum Sensing in the Pathogen Acinetobacter baumannii Using Non-native N-Acyl Homoserine Lactones. ACS Chemical Biology. 2012;7:1719-1728.
Praneenararat T, Palmer AG, Blackwell HE. Chemical methods to interrogate bacterial quorum sensing pathways. Organic & Biomolecular Chemistry. 2012;10:8189-8199.
Frei R, Breitbach AS, Blackwell HE. 2-Aminobenzimidazole Derivatives Strongly Inhibit and Disperse Pseudomonas aeruginosa Biofilms. Angewandte Chemie-International Edition. 2012;51:5226-5229.
Frei R, Breitbach AS, Blackwell HE. Expedient construction of small molecule macroarrays via sequential palladium- and copper-mediated reactions and their ex situ biological testing. Chemical Science. 2012;3:1555-1561.
Stringer JR, Bowman MD, Weisblum B, Blackwell HE. Improved Small-Molecule Macroarray Platform for the Rapid Synthesis and Discovery of Antibacterial Chalcones. ACS Combinatorial Science. 2011;13:175-180.
Praneenararat T, Beary TMJ, Breitbach AS, Blackwell HE. Synthesis and application of an N-acylated L-homoserine lactone derivatized affinity matrix for the isolation of quorum sensing signal receptors. Bioorganic & Medicinal Chemistry Letters. 2011;21:5054-5057.
Palmer AG, Streng E, Jewell KA, Blackwell HE. Quorum Sensing in Bacterial Species that Use Degenerate Autoinducers Can Be Tuned by Using Structurally Identical Non-native Ligands. Chembiochem. 2011;12:138-147.
McInnis CE, Blackwell HE. Thiolactone modulators of quorum sensing revealed through library design and screening. Bioorganic & Medicinal Chemistry. 2011;19:4820-4828.
McInnis CE, Blackwell HE. Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing. Bioorganic & Medicinal Chemistry. 2011;19:4812-4819.
Mattmann ME, Shipway PM, Heth NJ, Blackwell HE. Potent and Selective Synthetic Modulators of a Quorum Sensing Repressor in Pseudomonas aeruginosa Identified from Second-Generation Libraries of N-Acylated L-Homoserine Lactones. Chembiochem. 2011;12:942-949.
Lindemann A, Pessi G, Schaefer AL, Mattmann ME, Christensen QH, Kessler A, et al.. Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum. Proceedings of the National Academy of Sciences of the United States of America. 2011;108:16765-16770.
Crapster AJ, Stringer JR, Guzei IA, Blackwell HE. Design and Conformational Analysis of Peptoids Containing N-Hydroxy Amides Reveals a Unique Sheet-Like Secondary Structure. Biopolymers. 2011;96:604-616.
Blackwell HE, Fuqua C. Introduction to Bacterial Signals and Chemical Communication. Chemical Reviews. 2011;111:1-3.
Palmer AG, Streng E, Blackwell HE. Attenuation of Virulence in Pathogenic Bacteria Using Synthetic Quorum-Sensing Modulators under Native Conditions on Plant Hosts. ACS Chemical Biology. 2011;6:1348-1356.
Breitbach AS, Broderick AH, Jewell CM, Gunasekaran S, Lin Q, Lynn DM, et al.. Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity. Chemical Communications. 2011;47:370-372.
Stringer JR, Crapster AJ, Guzei IA, Blackwell HE. Construction of Peptoids with All Trans-Amide Backbones and Peptoid Reverse Turns via the Tactical Incorporation of N-Aryl Side Chains Capable of Hydrogen Bonding. Journal of Organic Chemistry. 2010;75:6068-6078.
Mattmann ME, Blackwell HE. Small Molecules That Modulate Quorum Sensing and Control Virulence in Pseudomonas aeruginosa. Journal of Organic Chemistry. 2010;75:6737-6746.
Frei R, Blackwell HE. Small Molecule Macroarray Construction via Palladium-Mediated Carbon-Carbon Bond-Forming Reactions: Highly Efficient Synthesis and Screening of Stilbene Arrays. Chemistry-A European Journal. 2010;16:2692-2695.
Breitbach AS, Broderick AH, Jewell CM, Gunasekaran S, Lin Q, Lynn DM, et al.. Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity. Chemical Communications. 2010;47:370-372.
Borlee BR, Geske GD, Blackwell HE, Handelsman J. Identification of Synthetic Inducers and Inhibitors of the Quorum-Sensing Regulator LasR in Pseudomonas aeruginosa by High-Throughput Screening. Applied and Environmental Microbiology. 2010;76:8255-8258.
Praneenararat T, Geske GD, Blackwell HE. Efficient Synthesis and Evaluation of Quorum-Sensing Modulators Using Small Molecule Macroarrays. Organic Letters. 2009;11:4600-4603.
Fowler SA, Luechapanichkul R, Blackwell HE. Synthesis and Characterization of Nitroaromatic Peptoids: Fine Tuning Peptoid Secondary Structure through Monomer Position and Functionality. Journal of Organic Chemistry. 2009;74:1440-1449.
Fowler SA, Blackwell HE. Structure-function relationships in peptoids: Recent advances toward deciphering the structural requirements for biological function. Organic & Biomolecular Chemistry. 2009;7:1508-1524.
Campbell J, Lin Q, Geske GD, Blackwell HE. New and Unexpected Insights into the Modulation of LuxR-Type Quorum Sensing by Cyclic Dipeptides. ACS Chemical Biology. 2009;4:1051-1059.
Campbell J, Blackwell HE. Efficient Construction of Diketopiperazine Macroarrays Through a Cyclative-Cleavage Strategy and Their Evaluation as Luminescence Inhibitors in the Bacterial Symbiont Vibrio fischeri. Journal of Combinatorial Chemistry. 2009;11:1094-1099.
Buck ME, Breitbach AS, Belgrade SK, Blackwell HE, Lynn DM. Chemical Modification of Reactive Multilayered Films Fabricated from Poly(2-alkenyl azlactone)s: Design of Surfaces that Prevent or Promote Mammalian Cell Adhesion and Bacterial Biofilm Growth. Biomacromolecules. 2009;10:1564-1574.
Palmer AG, Blackwell HE. Deciphering a protolanguage for bacteria-host communication. Nature Chemical Biology. 2008;4:452-454.
Mattmann ME, Geske GD, Worzalla GA, Chandler JR, Sappington KJ, Greenberg PE, et al.. Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa. Bioorganic & Medicinal Chemistry Letters. 2008;18:3072-3075.
Geske GD, Oneill JC, Miller DM, Wezeman RJ, Mattmann ME, Lin Q, et al.. Comparative analyses of N-acylated homoserine Lactones reveal unique structural features that dictate their ability to activate or inhibit quorum sensing. Chembiochem. 2008;9:389-400.
Geske GD, O'Neill JC, Blackwell HE. Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria. Chemical Society Reviews. 2008;37:1432-1447.
Geske GD, Mattmann ME, Blackwell HE. Evaluation of a focused library of N-aryl L-homoserine lactones reveals a new set of potent quorum sensing modulators. Bioorganic & Medicinal Chemistry Letters. 2008;18:5978-5981.
Fowler SA, Stacy DM, Blackwell HE. Design and synthesis of macrocyclic peptomers as mimics of a quorum sensing signal from Staphylococcus aureus. Organic Letters. 2008;10:2329-2332.
Borlee BR, Geske GD, Robinson CJ, Blackwell HE, Handelsman J. Quorum-sensing signals in the microbial community of the cabbage white butterfly larval midgut. ISME Journal. 2008;2:1101-1111.
O'Neill JC, Blackwell HE. Solid-phase and microwave-assisted syntheses of 2,5-diketopiperazines: Small molecules with great potential. Combinatorial Chemistry & High Throughput Screening. 2007;10:857-876.
Gorske BC, Bastian BL, Geske GD, Blackwell HE. Local and tunable n ->pi* interactions regulate amide isomerism in the peptoid backbone. Journal of the American Chemical Society. 2007;129:8928-+.
Geske GD, O'Neill JC, Miller DM, Mattmann ME, Blackwell HE. Modulation of bacterial quorum sensing with synthetic ligands: Systematic evaluation of N-acylated homoserine lactones in multiple species and new insights into their mechanisms of action. Journal of the American Chemical Society. 2007;129:13613-13625.
Geske GD, O'Neill JC, Blackwell HE. N-phenylacetanoyl-L-homoserine lactones can strongly antagonize or superagonize quorum sensing in. ACS Chemical Biology. 2007;2:315-U1.
Chan YY, Bian HS, Tan TMC, Mattmann ME, Geske GD, Igarashi J, et al.. Control of quorum sensing by a Burkholderia pseudomallei multidrug efflux pump. Journal of Bacteriology. 2007;189:4320-4324.
Bowman MD, O'Neill JC, Stringer JR, Blackwell HE. Rapid identification of antibacterial agents effective against Staphylococcus aureus using small-molecule macroarrays. Chemistry & Biology. 2007;14:351-357.
Lin Q, Blackwell HE. Rapid synthesis of diketopiperazine macroarrays via Ugi four-component reactions on planar solid supports. Chemical Communications. 2006;:2884.
Hollenbeck JJ, Wixson EN, Geske GD, Dodge MW, Tseng TA, Clauss AD, et al.. A new model for transitioning students from the undergraduate teaching laboratory to the research laboratory - The evolution of an intermediate organic synthesis laboratory course. Journal of Chemical Education. 2006;83:1835.
Gorske BC, Blackwell HE. Tuning peptoid secondary structure with pentafluoroaromatic functionality: A new design paradigm for the construction of discretely folded peptoid structures. Journal of the American Chemical Society. 2006;128:14378.
Guzei IA, Gorske BC, Blackwell HE. N-[1-(Pentafluorophenyl)ethyl]-acetamide. Acta Crystallographica - Section C - Crystal Structure Communications. 2006;62:O286-O288.
Gorske BC, Blackwell HE. Interception of quorum sensing in Staphylococcus aureus: a new niche for peptidomimetics (vol 4, pg 1441, 2006). Organic & Biomolecular Chemistry. 2006;4:2050.
Bowman MD, Jacobson MM, Pujanauski BG, Blackwell HE. Efficient synthesis of small molecule macroarrays: optimization of the macroarray synthesis platform and examination of microwave and conventional heating methods. Tetrahedron. 2006;62:4715-4727.
Bowman MD, Jacobson MM, Blackwell HE. Discovery of fluorescent cyanopyridine and deazalumazine dyes using small molecule macroarrays. Organic Letters. 2006;8:1645-1648.
Geske GD, Wezeman RJ, Siegel AP, Blackwell HE. Small molecule inhibitors of bacterial quorum sensing and biofilm formation. Journal of the American Chemical Society. 2005;127:12762-12763.
Lin Q, O'Neill JC, Blackwell HE. Small molecule macroarray construction via Ugi four-component reactions. Organic Letters. 2005;7:4455-4458.
Gorske BC, Jewell SA, Guerard EJ, Blackwell HE. Expedient synthesis and design strategies for new peptoid construction. Organic Letters. 2005;7:1521-1524.
Blackwell HE. Bacterial crowd control with iron. Chemistry & Biology. 2005;12:721-723.
Bowman MD, Jeske RC, Blackwell HE. Microwave-accelerated SPOT-synthesis on cellulose supports. Organic Letters. 2004;6:2019-2022.
Zhao YD, Dai XH, Blackwell HE, Schreiber SL, Chory J. SIR1, an upstream component in auxin signaling identified by chemical genetics. Science. 2003;301:1107-1110.
Blackwell HE, Zhao YD. Chemical genetic approaches to plant biology. Plant Physiology. 2003;133:448-455.
Blackwell HE. Out of the oil bath and into the oven - microwave-assisted combinatorial chemistry heats up. Organic & Biomolecular Chemistry. 2003;1:1251-1255.
Spring DR, Krishnan S, Blackwell HE, Schreiber SL. Diversity-oriented synthesis of biaryl-containing medium rings using a one bead/one stock solution platform. Journal of the American Chemical Society. 2002;124:1354-1363.
Grozinger CM, Chao ED, Blackwell HE, Moazed D, Schreiber SL. Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening. Journal of Biological Chemistry. 2001;276:38837-38843.
Blackwell HE, Sadowsky JD, Howard RJ, Sampson JN, Chao JA, Steinmetz WE, et al.. Ring-closing metathesis of olefinic peptides: Design, synthesis, and structural characterization of macrocyclic helical peptides. Journal of Organic Chemistry. 2001;66:5291-5302.
Blackwell HE, Perez L, Stavenger RA, Tallarico JA, Eatough EC, Foley MA, et al.. A one-bead, one-stock solution approach to chemical genetics: part 1. Chemistry & Biology. 2001;8:1167-1182.
Blackwell HE, Perez L, Schreiber SL. Decoding products of diversity pathways from stock solutions derived from single polymeric macrobeads. Angewandte Chemie-International Edition. 2001;40:3421-+.
Blackwell HE, Clemons PA, Schreiber SL. Exploiting site-site interactions on solid support to generate dimeric molecules. Organic Letters. 2001;3:1185-1188.
Blackwell HE, O'Leary DJ, Chatterjee AK, Washenfelder RA, Bussmann DA, Grubbs RH. New approaches to olefin cross-metathesis. Journal of the American Chemical Society. 2000;122:58-71.
O'Leary DJ, Blackwell HE, Washenfelder RA, Miura K, Grubbs RH. Terminal olefin cross-metathesis with acrolein acetals. Tetrahedron Letters. 1999;40:1091-1094.
O'Leary DJ, Blackwell HE, Washenfelder RA, Grubbs RH. A new method for cross-metathesis of terminal olefins. Tetrahedron Letters. 1998;39:7427-7430.
Blackwell HE, Grubbs RH. Highly efficient synthesis of covalently cross-linked peptide helices by ring-closing metathesis. Angewandte Chemie-International Edition. 1998;37:3281-3284.
Miller SJ, Blackwell HE, Grubbs RH. Application of ring-closing metathesis to the synthesis of rigidified amino acids and peptides. Journal of the American Chemical Society. 1996;118:9606-9614.