Publications

Prier CK, Zhang RK, Buller AR, Brinkmann-Chen S, Arnold FH. Enantioselective, intermolecular benzylic C-H amination catalysed by an engineered iron-haem enzyme. Nature Chemistry. 2017;9:629-634.
Cahn JKB, Brinkmann-Chen S, Buller AR, Arnold FH. Artificial domain duplication replicates evolutionary history of ketol-acid reductoisomerases. Protein Science. 2016;25:1241-1248.
Herger M, van Roye P, Romney DK, Brinkmann-Chen S, Buller AR, Arnold FH. Synthesis of beta-Branched Tryptophan Analogues Using an Engineered Subunit of Tryptophan Synthase. Journal of the American Chemical Society. 2016;138:8388-8391.
Murciano-Calles J, Romney DK, Brinkmann-Chen S, Buller AR, Arnold FH. A Panel of TrpB Biocatalysts Derived from Tryptophan Synthase through the Transfer of Mutations that Mimic Allosteric Activation. Angewandte Chemie-International Edition. 2016;55:11577-11581.
Buller AR, van Roye P, Murciano-Calles J, Arnold FH. Tryptophan Synthase Uses an Atypical Mechanism To Achieve Substrate Specificity. Biochemistry. 2016;55:7043-7046.
Cahn JKB, Brinkmann-Chen S, Spatzal T, Wiig JA, Buller AR, Einsle O, et al.. Cofactor specificity motifs and the induced fit mechanism in class I ketol-acid reductoisomerases. Biochemical Journal. 2015;468:475-484.
Marous DR, Lloyd EP, Buller AR, Moshos KA, Grove TL, Blaszczyk AJ, et al.. Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 2015;112:10354-10358.
McIntosh JA, Heel T, Buller AR, Chio L, Arnold FH. Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450. Journal of the American Chemical Society. 2015;137:13861-13865.
Buller AR, Brinkmann-Chen S, Romney DK, Herger M, Murciano-Calles J, Arnold FH. Directed evolution of the tryptophan synthase beta-subunit for stand-alone function recapitulates allosteric activation. Proceedings of the National Academy of Sciences of the United States of America. 2015;112:14599-14604.
Buller AR, Freeman MF, Schildbach JF, Townsend CA. Exploring the Role of Conformational Heterogeneity in cis-Autoproteolytic Activation of ThnT. Biochemistry. 2014;53:4273-4281.
Hyster TK, Farwell CC, Buller AR, McIntosh JA, Arnold FH. Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C-H Amination. Journal of the American Chemical Society. 2014;136:15505-15508.
Buller AR, Townsend CA. Intrinsic evolutionary constraints on protease structure, enzyme acylation, and the identity of the catalytic triad. Proceedings of the National Academy of Sciences of the United States of America. 2013;110:E653-E661.
Buller AR, Freeman MF, Wright NT, Schildbach JF, Townsend CA. Insights into cis-autoproteolysis reveal a reactive state formed through conformational rearrangement. Proceedings of the National Academy of Sciences of the United States of America. 2012;109:2308-2313.
Buller AR, Labonte JW, Freeman MF, Wright NT, Schildbach JF, Townsend CA. Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis. Journal of Molecular Biology. 2012;422:508-518.
Bassuk AG, Wallace RH, Buhr A, Buller AR, Afawi Z, Shimojo M, et al.. A Homozygous Mutation in Human PRICKLE1 Causes an Autosomal-Recessive Progressive Myoclonus Epilepsy-Ataxia Syndrome. American Journal of Human Genetics. 2008;83:572-581.