All Faculty and Research Staff Publications

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Murray JK, Gellman SH. Application of microwave irradiation to the synthesis of 14-helical beta-peptides. Organic Letters. 2005 ;7:1517-1520.
Espinosa JF, Syud FA, Gellman SH. An autonomously folding beta-hairpin derived from the human YAP65 WW domain: Attempts to define a minimum ligand-binding motif. Biopolymers. 2005 ;80:303-311.
Epand RF, Schmitt MA, Gellman SH, Sen A, Auger M, Hughes DW, Epand RM. Bacterial species selective toxicity of two isomeric alpha/beta-peptides: Role of membrane lipids. Molecular Membrane Biology. 2005 ;22:457-469.
Sadowsky JD, Schmitt MA, Lee HS, Umezawa N, Wang SM, Tomita Y, Gellman SH. Chimeric (alpha/beta plus alpha)-peptide ligands for the BH3-recognition cleft of Bcl-x(L): Critical role of the molecular scaffold in protein surface recognition. Journal of the American Chemical Society. 2005 ;127:11966-11968.
Theisen MJ, Potocky TB, D. McQuade T, Gellman SH, Chiu ML. Crystallization of bacteriorhodopsin solubilized by a tripod amphiphile. Biochimica et Biophysica Acta, Proteins and Proteomics. 2005 ;1751:213-216.
Chi YG, Gellman SH. Diphenylprolinol methyl ether: A highly enantioselective catalyst for Michael addition of aldehydes to simple enones. Organic Letters. 2005 ;7:4253-4256.
Potocky TB, Menon AK, Gellman SH. Effects of conformational stability and geometry of guanidinium display on cell entry by beta-peptides. Journal of the American Chemical Society. 2005 ;127:3686-3687.
Eldred SE, Pancost MR, Otte KM, Rozema D, Stahl SS, Gellman SH. Effects of side chain configuration and backbone spacing on the gene delivery properties of lysine-derived cationic polymers. Bioconjugate Chemistry. 2005 ;16:694-699.
Murray JK, Farooqi B, Sadowsky JD, Scalf M, Freund WA, Smith LM, Chen JD, Gellman SH. Efficient synthesis of a beta-peptide combinatorial library with microwave irradiation. Journal of the American Chemical Society. 2005 ;127:13271-13280.
Chi Y, Peelen TJ, Gellman SH. A rapid 1H NMR assay for enantiomeric excess of α-substituted aldehydes. Organic Letters. 2005 ;7:3469-3472.
Schmitt MA, Choi SH, Guzei IA, Gellman SH. Residue requirements for helical folding in short alpha/beta-peptides: Crystallographic characterization of the 11-helix in an optimized sequence. Journal of the American Chemical Society. 2005 ;127:13130-13131.
Gilbert PUPA, Schmitt MA, Gellman SH. Spectromicroscopy at the organic-inorganic interface in biominerals. American Journal of Science. 2005 ;305:673-686.
Gellman SH. Structure and function in foldamers. Polymer Preprints. 2005 ;46:169.
Huck BR, Gellman SH. Synthesis of 2,2-disubstituted pyrrolidine-4-carboxylic acid derivatives and their incorporation into beta-peptide oligomers. Journal of Organic Chemistry. 2005 ;70:3353-3362.
Kissounko DA, Guzei IA, Gellman SH, Stahl SS. Titanium(IV)-mediated conversion of carboxamides to amidines and implications for catalytic transamidation. Organometallics. 2005 ;24:5208-5210.
Porter EA, Weisblum B, Gellman SH. Use of parallel synthesis to probe structure-activity relationships among 12-helical beta-peptides: Evidence of a limit on antimicrobial activity. Journal of the American Chemical Society. 2005 ;127:11516-11529.
Gelman MA, Gellman SH. Using constrained b-amino acid residues to control b-peptide shape and function. Enantioselective Synthesis of b-Amino Acids (2nd Edition). 2005 :527-591.
Epand RF, Raguse TL, Gellman SH, Epand RM. Antimicrobial 14-helical beta-peptides: Potent bilayer disrupting agents. Biochemistry. 2004 ;43:9527-9535.
Woll MG, Gellman SH. Backbone thioester exchange: A new approach to evaluating higher order structural stability in polypeptides. Journal of the American Chemical Society. 2004 ;126:11172-11174.
Gelman MA, Weisblum B, Lynn DM, Gellman SH. Biocidal activity of polystyrenes that are cationic by virtue of protonation. Organic Letters. 2004 ;6:557-560.
Langenhan JM, Gellman SH. Effects of alternative side chain pairings and reverse turn sequences on antiparallel sheet structure in beta-peptide hairpins. Organic Letters. 2004 ;6:937-940.
Lai JR, Fisk JD, Weisblum B, Gellman SH. Hydrophobic core repacking in a coiled-coil dimer via phage display: Insights into plasticity and specificity at a protein-protein interface. Journal of the American Chemical Society. 2004 ;126:10514-10515.
Peelen TJ, Chi YG, English EP, Gellman SH. Synthesis of 4,4-disubstituted 2-aminocyclopentanecarboxylic acid derivatives and their incorporation into 12-helical beta-peptides. Organic Letters. 2004 ;6:4411-4414.
Hayen A, Schmitt MA, Ngassa FN, Thomasson KA, Gellman SH. Two helical conformations from a single foldamer backbone: "Split personality" in short alpha/beta-peptides. Angewandte Chemie-International Edition. 2004 ;43:505-510.
Schmitt MA, Weisblum B, Gellman SH. Unexpected relationships between structure and function in alpha,beta-peptides: Antimicrobial foldamers with heterogeneous backbones. Journal of the American Chemical Society. 2004 ;126:6848-6849.
Park JS, Lee HS, Lai JR, Kim BM, Gellman SH. Accommodation of alpha-substituted residues in the beta-peptide 12-helix: Expanding the range of substitution patterns available to a foldamer scaffold. Journal of the American Chemical Society. 2003 ;125:8539-8545.
Schinnerl M, Murray JK, Langenhan JM, Gellman SH. Asymmetric synthesis of a new helix-forming beta-amino acid: trans-4-aminopiperidine-3-carboxylic acid. European Journal of Organic Chemistry. 2003 :721-726.
Eldred SE, Stone DA, Gellman SH, Stahl SS. Catalytic transamidation under moderate conditions. Journal of the American Chemical Society. 2003 ;125:3422-3423.
Potocky TB, Menon AK, Gellman SH. Cytoplasmic and nuclear delivery of a TAT-derived peptide and a beta-peptide after endocytic uptake into HeLa cells. Journal of Biological Chemistry. 2003 ;278:50188-50194.
Lee H-S, Park J-S, Kim BM, Gellman SH. Efficient Synthesis of Enantiomerically Pure β2-Amino Acids via Chiral Isoxazolidinones. Journal of Organic Chemistry. 2003 ;68:1575-1578.
Raguse TL, Lai JR, Gellman SH. Environment-independent 14-helix formation in short beta-peptides: Striking a balance between shape control and functional diversity. Journal of the American Chemical Society. 2003 ;125:5592-5593.
Syud FA, Stanger HE, Mortell HS, Espinosa JF, Fisk JD, Fry CG, Gellman SH. Influence of strand number on antiparallel beta-sheet stability in designed three- and four-stranded beta-sheets. Journal of Molecular Biology. 2003 ;326:553-568.
Epand RF, Umezawa N, Porter EA, Gellman SH, Epand RM. Interactions of the antimicrobial beta-peptide beta-17 with phospholipid vesicles differ from membrane interactions of magainins. European Journal of Biochemistry. 2003 ;270:1240-1248.
Bruckner AM, Chakraborty P, Gellman SH, Diederichsen U. Molecular architecture with functionalized beta-peptide helices. Angewandte Chemie-International Edition. 2003 ;42:4395-4399.
Langenhan JM, Guzei IA, Gellman SH. Parallel sheet secondary structure in beta-peptides. Angewandte Chemie-International Edition. 2003 ;42:2402-2405.
Langenhan JM, Gellman SH. Preparation of protected syn-alpha,beta-dialkyl beta-amino acids that contain polar side chain functionality. Journal of Organic Chemistry. 2003 ;68:6440-6443.
Lai JR, Gellman SH. Reinvestigation of the proposed folding and self-association of the Neuropeptide Head Activator. Protein Science. 2003 ;12:560-566.
Huck BR, Fisk JD, Guzei IA, Carlson HA, Gellman SH. Secondary Structural Preferences of 2,2-Disubstituted Pyrrolidine-4-carboxylic Acid Oligomers: β-Peptide Foldamers that Cannot Form Internal Hydrogen Bonds. Journal of the American Chemical Society. 2003 ;125:9035-9037.
Gelman MA, Richter S, Cao H, Umezawa N, Gellman SH, Rana TM. Selective binding of TAR RNA by a tat-derived beta-peptide. Organic Letters. 2003 ;5:3563-3565.
Gellman SH. Structure and function in b-peptide foldamers. Polymer Preprints. 2003 ;44:461.
Bruckner AM, Garcia M, Marsh A, Gellman SH, Diederichsen U. Synthesis of novel nucleo-beta-amino acids and nucleobase-functionalized beta-peptides. European Journal of Organic Chemistry. 2003 :3555-3561.