All Faculty and Research Staff Publications

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Holmgren SK, Taylor KM, Bretscher LE, Raines RT. Code for collagen's stability deciphered. Nature. 1998 ;392:666-667.
Fisher BM, Schultz LW, Raines RT. Coulombic effects of remote subsites on the active site of ribonuclease A. Biochemistry. 1998 ;37:17386-17401.
Fisher BM, Ha JH, Raines RT. Coulombic forces in protein-RNA interactions: Binding and cleavage by ribonuclease A and variants at Lys7, Arg10, and Lys66. Biochemistry. 1998 ;37:12121-12132.
Wittmayer PK, McKenzie JL, Raines RT. Degenerate DNA recognition by I-PpoI endonuclease. Gene. 1998 ;206:11-21.
Quirk DJ, Park C, Thompson JE, Raines RT. His - Asp catalytic dyad of ribonuclease A: Conformational stability of the wild-type, D121N, D121A, and H119A enzymes. Biochemistry. 1998 ;37:17958-17964.
Schultz LW, Quirk DJ, Raines RT. His - Asp catalytic dyad of ribonuclease A: Structure and function of the wild-type, D121N, and D121A enzymes. Biochemistry. 1998 ;37:8886-8898.
Shusta EV, Raines RT, Pluckthun A, Wittrup KD. Increasing the secretory capacity of Saccharomyces cerevisiae for production of single-chain antibody fragments. Nature Biotechnology. 1998 ;16:773-777.
Fisher BM, Grilley JE, Raines RT. A new remote subsite in ribonuclease A. Journal of Biological Chemistry. 1998 ;273:34134-34138.
Kothandaraman S, Hebert MC, Raines RT, Nibert ML. No role for pepstatin-A-sensitive acidic proteinases in reovirus infections of L or MDCK cells. Virology. 1998 ;251:264-272.
Raines RT. Ribonuclease A. Chemical Reviews. 1998 ;98:1045-1065.
Leland PA, Schultz LW, Kim BM, Raines RT. Ribonuclease A variants with potent cytotoxic activity. Proceedings of the National Academy of Sciences of the United States of America. 1998 ;95:10407-10412.
Schultz LW, Hargraves SR, Klink TA, Raines RT. Structure and stability of the P93G variant of ribonuclease A. Protein Science. 1998 ;7:1620-1625.
Mannino SJ, Jenkins CL, Raines RT. Chemical mechanism of DNA cleavage by the homing endonuclease I-PpoI. Biochemistry. 1999 ;38:16178-16186.
Schultz LW, Chivers PT, Raines RT. The CXXC motif: crystal structure of an active-site variant of Escherichia coli thioredoxin. Acta Crystallographica Section D-Biological Crystallography. 1999 ;55:1533-1538.
Kelemen BR, Raines RT. Extending the limits to enzymatic catalysis: Diffusion of ribonuclease A in one dimension. Biochemistry. 1999 ;38:5302-5307.
Quirk DJ, Raines RT. His - Asp catalytic dyad of ribonuclease A: Histidine pK(a) values in the wild-type, D121N, and D121A enzymes. Biophysical Journal. 1999 ;76:1571-1579.
Kelemen BR, Klink TA, Behlke MA, Eubanks SR, Leland PA, Raines RT. Hypersensitive substrate for ribonucleases. Nucleic Acids Research. 1999 ;27:3696-3701.
Holmgren SK, Bretscher LE, Taylor KM, Raines RT. A hyperstable collagen mimic. Chemistry & Biology. 1999 ;6:63-70.
Woycechowsky KJ, Wittrup KD, Raines RT. A small-molecule catalyst of protein folding in vitro and in vivo. Chemistry & Biology. 1999 ;6:871-879.
Soucek J, Raines RT, Haugg M, Raillard-Yoon SA, Benner SA. Structural changes to ribonuclease A and their effects on biological activity. Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology. 1999 ;123:103-111.
Kim BM, Schultz LW, Raines RT. Variants of ribonuclease inhibitor that resist oxidation. Protein Science. 1999 ;8:430-434.
Abel R, Hondal RJ, Raines RT. Active-site variants of ribonuclease A. Biochemistry. 2001 ;40:8647-8647.
Leland PA, Raines RT. Cancer chemotherapy - ribonucleases to the rescue. Chemistry & Biology. 2001 ;8:405-413.
Jardine AM, Leonidas DD, Jenkins JL, Park C, Raines RT, Acharya KR, Shapiro R. Cleavage of 3 ',5 '-pyrophosphate-linked dinucleotides by ribonuclease A and angiogenin. Biochemistry. 2001 ;40:10262-10272.
Bretscher LE, Jenkins CL, Taylor KM, DeRider ML, Raines RT. Conformational stability of collagen relies on a stereoelectronic effect. Journal of the American Chemical Society. 2001 ;123:777-778.
Chandran SS, Taylor KM, Raines RT. Contribution of individual modules of a leucine-rich repeat protein to its affinity for other proteins. Biochemistry. 2001 ;40:8615-8616.
Kersteen EA, Raines RT. Contribution of tertiary amides to the conformational stability of collagen triple helices. Biopolymers. 2001 ;59:24-28.
Park C, Schultz LW, Raines RT. Contribution of the active site histidine residues of ribonuclease A to nucleic acid binding. Biochemistry. 2001 ;40:4949-4956.
Leland PA, Staniszewski KE, Kim BM, Raines RT. Endowing human pancreatic ribonuclease with toxicity for cancer cells. Journal of Biological Chemistry. 2001 ;276:43095-43102.
Park C, Kelemen BR, Klink TA, Sweeney RY, Behlke MA, Eubanks SR, Raines RT. Fast, facile, hypersensitive assays for ribonucleolytic activity. In: Vol. 341. San Diego: Academic Press Inc; 2001. pp. 81-94.
Klink TA, Vicentini AM, Hofsteenge J, Raines RT. High-level soluble production and characterization of porcine ribonuclease inhibitor. Protein Expression & Purification. 2001 ;22:174-179.
Nilsson BL, Kiessling LL, Raines RT. High-yielding Staudinger ligation of a phosphinothioester and azide to form a peptide. Organic Letters. 2001 ;3:9-12.
Park C, Raines RT. Quantitative analysis of the effect of salt concentration on enzymatic catalysis. Journal of the American Chemical SocietyJournal of the American Chemical Society. 2001 ;123:11472-11479.
Plainkum P, Fuchs SM, Raines RT. A ribonuclease zymogen as a chemotherapeutic for malaria. FASEB Journal. 2001 ;15:A538-A538.
Lee JWE, Raines RT. Role of lysine residues in the active site of onconase. Biochemistry. 2001 ;40:8627-8627.
Arnold U, Hinderaker MP, Nilsson BL, Huck BR, Gellman SH, Raines RT. Semisynthesis of proteins containing nonnatural modules. Biochemistry. 2001 ;40:8627-8628.
Hinderaker MP, Arnold U, Raines RT. Stabilization of semi-synthetic ribonuclease A with covalent mimics of disulfide bonds. Biochemistry. 2001 ;40:8628-8628.
Hondal RJ, Abel RL, Raines RT. Stereochemical consequences of catalysis by ribonuclease A: Nonnatural variants and phosphorothioate substrates. Biochemistry. 2001 ;40:8645-8645.
DeRider ML, Wilkens SJ, Waddell MJ, Bretscher LE, Weinhold F, Raines RT, Markley JL. Collagen stability: Insights from NMR spectroscopic and hybrid density functional computational investigations of the effect of electronegative substituents on prolyl ring conformations. Journal of the American Chemical Society. 2002 ;124:2497-2505.
Haigis MC, Haag ES, Raines RT. Evolution of ribonuclease inhibitor by exon duplication. Molecular Biology & Evolution. 2002 ;19:959-963.
Abel RL, Haigis MC, Park C, Raines RT. Fluorescence assay for the binding of ribonuclease A to the ribonuclease inhibitor protein. Analytical Biochemistry. 2002 ;306:100-107.
Park SH, Raines RT. Genetic screen to dissect protein-protein interactions: ribonuclease inhibitor-ribonuclease A as a model system. Methods. 2002 ;28:346-352.
Jenkins CL, Raines RT. Insights on the conformational stability of collagen. Natural Product Reports. 2002 ;19:49-59.
Haigis MC, Kurten EL, Abel RL, Raines RT. KFERQ sequence in ribonuclease A-mediated cytotoxicity. Journal of Biological Chemistry. 2002 ;277:11576-11581.
Gellman SH, Raines RT. Model systems - This year's model - Editorial overview. Current Opinion in Chemical Biology. 2002 ;6:727-728.
Arnold U, Hinderaker MP, Nilsson BL, Huck BR, Gellman SH, Raines RT. Protein prosthesis: A semisynthetic enzyme with a beta-peptide reverse turn. Journal of the American Chemical Society. 2002 ;124:8522-8523.