All Faculty and Research Staff Publications

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Palmer AG, Streng E, Blackwell HE. Attenuation of Virulence in Pathogenic Bacteria Using Synthetic Quorum-Sensing Modulators under Native Conditions on Plant Hosts. ACS Chemical Biology. 2011 ;6:1348-1356.
Crapster AJ, Stringer JR, Guzei IA, Blackwell HE. Design and Conformational Analysis of Peptoids Containing N-Hydroxy Amides Reveals a Unique Sheet-Like Secondary Structure. Biopolymers. 2011 ;96:604-616.
McInnis CE, Blackwell HE. Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing. Bioorganic & Medicinal Chemistry. 2011 ;19:4812-4819.
Stringer JR, Crapster JA, Guzei IA, Blackwell HE. Extraordinarily Robust Polyproline Type I Peptoid Helices Generated via the Incorporation of alpha-Chiral Aromatic N-1-Naphthylethyl Side Chains. Journal of the American Chemical Society. 2011 ;133:15559-15567.
Stringer JR, Bowman MD, Weisblum B, Blackwell HE. Improved Small-Molecule Macroarray Platform for the Rapid Synthesis and Discovery of Antibacterial Chalcones. ACS Combinatorial Science. 2011 ;13:175-180.
Blackwell HE, Fuqua C. Introduction to Bacterial Signals and Chemical Communication. Chemical Reviews. 2011 ;111:1-3.
Lindemann A, Pessi G, Schaefer AL, Mattmann ME, Christensen QH, Kessler A, Hennecke H, Blackwell HE, Greenberg PE, Harwood CS. Isovaleryl-homoserine lactone, an unusual branched-chain quorum-sensing signal from the soybean symbiont Bradyrhizobium japonicum. Proceedings of the National Academy of Sciences of the United States of America. 2011 ;108:16765-16770.
Mattmann ME, Shipway PM, Heth NJ, Blackwell HE. Potent and Selective Synthetic Modulators of a Quorum Sensing Repressor in Pseudomonas aeruginosa Identified from Second-Generation Libraries of N-Acylated L-Homoserine Lactones. Chembiochem. 2011 ;12:942-949.
Palmer AG, Streng E, Jewell KA, Blackwell HE. Quorum Sensing in Bacterial Species that Use Degenerate Autoinducers Can Be Tuned by Using Structurally Identical Non-native Ligands. Chembiochem. 2011 ;12:138-147.
Breitbach AS, Broderick AH, Jewell CM, Gunasekaran S, Lin Q, Lynn DM, Blackwell HE. Surface-mediated release of a synthetic small-molecule modulator of bacterial quorum sensing: Gradual release enhances activity. Chemical Communications. 2011 ;47:370-372.
Praneenararat T, Beary TMJ, Breitbach AS, Blackwell HE. Synthesis and application of an N-acylated L-homoserine lactone derivatized affinity matrix for the isolation of quorum sensing signal receptors. Bioorganic & Medicinal Chemistry Letters. 2011 ;21:5054-5057.
McInnis CE, Blackwell HE. Thiolactone modulators of quorum sensing revealed through library design and screening. Bioorganic & Medicinal Chemistry. 2011 ;19:4820-4828.
Moore JD, Gerdt JP, Eibergen NR, Blackwell HE. Active Efflux Influences the Potency of Quorum Sensing Inhibitors in Pseudomonas aeruginosa. Chembiochem. 2014 ;15:435-442.
Gerdt JP, Blackwell HE. Competition Studies Confirm Two Major Barriers That Can Preclude the Spread of Resistance to Quorum-Sensing Inhibitors in Bacteria. ACS Chemical Biology. 2014 ;9:2291-2299.
Gerdt JP, McInnis CE, Schell TL, Rossi FM, Blackwell HE. Mutational Analysis of the Quorum-Sensing Receptor LasR Reveals Interactions that Govern Activation and Inhibition by Nonlactone Ligands. Chemistry & Biology. 2014 ;21:1361-1369.
Tal-Gan Y, Stacy DM, Blackwell HE. N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus. Chemical Communications. 2014 ;50:3000-3003.
Studer SV, Schwartzman JA, Ho JS, Geske GD, Blackwell HE, Ruby EG. Non-native acylated homoserine lactones reveal that LuxIR quorum sensing promotes symbiont stability. Environmental Microbiology. 2014 ;16:2623-2634.
McInnis CE, Blackwell HE. Non-native N-Aroyl (L)-Homoserine Lactones Are Potent Modulators of the Quorum Sensing Receptor RpaR in Rhodopseudomonas palustris. Chembiochem. 2014 ;15:87-93.
Palmer AG, Senechal AC, Mukherjee A, Ane JM, Blackwell HE. Plant Responses to Bacterial N-Acyl L-Homoserine Lactones are Dependent on Enzymatic Degradation to L-Homoserine. ACS Chemical Biology. 2014 ;9:1834-1845.
Broderick AH, Stacy DM, Tal-Gan Y, Kratochvil MJ, Blackwell HE, Lynn DM. Surface Coatings that Promote Rapid Release of Peptide-Based AgrC Inhibitors for Attenuation of Quorum Sensing in Staphylococcus aureus. Adv. Healthcare Mater. 2014 ;3:97-105.
Moore JD, Rossi FM, Welsh MA, Nyffeler KE, Blackwell HE. A Comparative Analysis of Synthetic Quorum Sensing Modulators in Pseudomonas aeruginosa: New Insights into Mechanism, Active Efflux Susceptibility, Phenotypic Response, and Next-Generation Ligand Design. Journal of the American Chemical Society. 2015 ;137:14626-14639.
Kratochvil MJ, Tal-Gan Y, Yang T, Blackwell HE, Lynn DM. Nanoporous Superhydrophobic Coatings that Promote the Extended Release of Water-Labile Quorum Sensing Inhibitors and Enable Long-Term Modulation of Quorum Sensing in Staphylococcus aureus. ACS Biomater. Sci. Eng. 2015 ;1:1039-1049.
Eibergen NR, Moore JD, Mattmann ME, Blackwell HE. Potent and Selective Modulation of the RhlR Quorum Sensing Receptor by Using Non-native Ligands: An Emerging Target for Virulence Control in Pseudomonas aeruginosa. Chembiochem. 2015 ;16:2348-56.
Welsh MA, Eibergen NR, Moore JD, Blackwell HE. Small Molecule Disruption of Quorum Sensing Cross-Regulation in Pseudomonas aeruginosa Causes Major and Unexpected Alterations to Virulence Phenotypes. Journal of the American Chemical Society. 2015 ;137:1510-1519.
Gerdt JP, McInnis CE, Schell TL, Blackwell HE. Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR. Organic & Biomolecular Chemistry. 2015 ;13:1453-1462.
Tal-Gan Y, Ivancic M, Cornilescu G, Blackwell HE. Characterization of structural elements in native autoinducing peptides and non-native analogues that permit the differential modulation of AgrC-type quorum sensing receptors in Staphylococcus aureus. Organic & Biomolecular Chemistry. 2016 ;14:113-121.
Welsh MA, Blackwell HE. Chemical Genetics Reveals Environment-Specific Roles for Quorum Sensing Circuits in Pseudomonas aeruginosa. Cell Chemical Biology. 2016 ;23:361-369.
Welsh MA, Blackwell HE. Chemical probes of quorum sensing: from compound development to biological discovery. FEMS Microbiology Reviews. 2016 ;40:774-794.
Tal-Gan Y, Ivancic M, Cornilescu G, Yang T, Blackwell HE. Highly Stable, Amide-Bridged Autoinducing Peptide Analogues that Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureus. Angewandte Chemie-International Edition. 2016 ;55:8913-8917.
Patel NM, Moore JD, Blackwell HE, Amador-Noguez D. Identification of Unanticipatedand Novel N-Acyl L-Homoserine Lactones (AHLs) Using a Sensitive Non-Targeted LC-MS/MS Method. Plos One. 2016 ;11.
Palmer AG, Mukherjee A, Stacy DM, Lazar S, Ane JM, Blackwell HE. Interkingdom Responses to Bacterial Quorum Sensing Signals Regulate Frequency and Rate of Nodulation in Legume-Rhizobia Symbiosis. Chembiochem. 2016 ;17:2199-2205.
Kratochvil MJ, Welsh MA, Manna U, Ortiz BJ, Blackwell HE, Lynn DM. Slippery Liquid-Infused Porous Surfaces that Prevent Bacterial Surface Fouling and Inhibit Virulence Phenotypes in Surrounding Planktonic Cells. Acs Infectious Diseases. 2016 ;2:509-517.
Manna U, Raman N, Welsh MA, Zayas-Gonzalez YM, Blackwell HE, Palecek SP, Lynn DM. Slippery Liquid-Infused Porous Surfaces that Prevent Microbial Surface Fouling and Kill Non-Adherent Pathogens in Surrounding Media: A Controlled Release Approach. Advanced Functional Materials. 2016 ;26:3599-3611.
O'Reilly MC, Blackwell HE. Structure-Based Design and Biological Evaluation of Triphenyl Scaffold-Based Hybrid Compounds as Hydrolytically Stable Modulators of a LuxR-Type Quorum Sensing Receptor. Acs Infectious Diseases. 2016 ;2:32-38.
Yang T, Tal-Gan Y, Paharik AE, Horswill AR, Blackwell HE. Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation. ACS Chemical Biology. 2016 ;11:1982-1991.