All Faculty and Research Staff Publications

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2018
Boursier ME, Manson DE, Combs JB, Blackwell HE. A comparative study of non-native N-acyl L-homoserine lactone analogs in two Pseudomonas aeruginosa quorum sensing receptors that share a common native ligand yet inversely regulate virulence. Bioorganic & Medicinal Chemistry. 2018 ;26:5336-5342.
Wysoczynski-Horita CL, Boursier ME, Hill R, Hansen K, Blackwell HE, Churchill MEA. Mechanism of agonism and antagonism of the Pseudomonas aeruginosa quorum sensing regulator QscR with non-native ligands. Molecular MicrobiologyMolecular Microbiology. 2018 ;108:240-257.
Styles MJ, Blackwell HE. Non-native autoinducer analogs capable of modulating the SdiA quorum sensing receptor in Salmonella enterica serovar Typhimurium. Beilstein Journal of Organic Chemistry. 2018 ;14:2651-2664.
Mooney JA, Pridgen EM, Manasherob R, Suh G, Blackwell HE, Barron AE, Bollyky PL, Goodman SB, Amanatullah DF. Periprosthetic Bacterial Biofilm and Quorum Sensing. Journal of Orthopaedic Research. 2018 ;36:2331-2339.
Palmer AG, Senechal AC, Haire TC, Mehta NP, Valiquette SD, Blackwell HE. Selection of Appropriate Autoinducer Analogues for the Modulation of Quorum Sensing at the Host-Bacterium Interface. ACS Chemical Biology. 2018 ;13:3115-3122.
Brown SP, Blackwell HE, Hammer BK. The State of the Union Is Strong: a Review of ASM's 6th Conference on Cell-Cell Communication in Bacteria. Journal of Bacteriology. 2018 ;200.
O'Reilly MC, Dong SH, Rossi FM, Karlen KM, Kumar RS, Nair SK, Blackwell HE. Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out'' Conformation for LasR. Cell Chemical Biology. 2018 ;25:1128-+.
Boursier ME, Moore JD, Heitman KM, Shepardson-Fungairino SP, Combs JB, Koenig LC, Shin D, Brown EC, Nagarajan R, Blackwell HE. Structure-Function Analyses of the N-Butanoyl L-Homoserine Lactone Quorum-Sensing Signal Define Features Critical to Activity in RhIR. ACS Chemical Biology. 2018 ;13:2655-2662.
2016
Tal-Gan Y, Ivancic M, Cornilescu G, Blackwell HE. Characterization of structural elements in native autoinducing peptides and non-native analogues that permit the differential modulation of AgrC-type quorum sensing receptors in Staphylococcus aureus. Organic & Biomolecular Chemistry. 2016 ;14:113-121.
Welsh MA, Blackwell HE. Chemical Genetics Reveals Environment-Specific Roles for Quorum Sensing Circuits in Pseudomonas aeruginosa. Cell Chemical Biology. 2016 ;23:361-369.
Welsh MA, Blackwell HE. Chemical probes of quorum sensing: from compound development to biological discovery. FEMS Microbiology Reviews. 2016 ;40:774-794.
Tal-Gan Y, Ivancic M, Cornilescu G, Yang T, Blackwell HE. Highly Stable, Amide-Bridged Autoinducing Peptide Analogues that Strongly Inhibit the AgrC Quorum Sensing Receptor in Staphylococcus aureus. Angewandte Chemie-International Edition. 2016 ;55:8913-8917.
Patel NM, Moore JD, Blackwell HE, Amador-Noguez D. Identification of Unanticipatedand Novel N-Acyl L-Homoserine Lactones (AHLs) Using a Sensitive Non-Targeted LC-MS/MS Method. Plos One. 2016 ;11.
Palmer AG, Mukherjee A, Stacy DM, Lazar S, Ane JM, Blackwell HE. Interkingdom Responses to Bacterial Quorum Sensing Signals Regulate Frequency and Rate of Nodulation in Legume-Rhizobia Symbiosis. Chembiochem. 2016 ;17:2199-2205.
Kratochvil MJ, Welsh MA, Manna U, Ortiz BJ, Blackwell HE, Lynn DM. Slippery Liquid-Infused Porous Surfaces that Prevent Bacterial Surface Fouling and Inhibit Virulence Phenotypes in Surrounding Planktonic Cells. Acs Infectious Diseases. 2016 ;2:509-517.
Manna U, Raman N, Welsh MA, Zayas-Gonzalez YM, Blackwell HE, Palecek SP, Lynn DM. Slippery Liquid-Infused Porous Surfaces that Prevent Microbial Surface Fouling and Kill Non-Adherent Pathogens in Surrounding Media: A Controlled Release Approach. Advanced Functional Materials. 2016 ;26:3599-3611.
O'Reilly MC, Blackwell HE. Structure-Based Design and Biological Evaluation of Triphenyl Scaffold-Based Hybrid Compounds as Hydrolytically Stable Modulators of a LuxR-Type Quorum Sensing Receptor. Acs Infectious Diseases. 2016 ;2:32-38.
Yang T, Tal-Gan Y, Paharik AE, Horswill AR, Blackwell HE. Structure-Function Analyses of a Staphylococcus epidermidis Autoinducing Peptide Reveals Motifs Critical for AgrC-type Receptor Modulation. ACS Chemical Biology. 2016 ;11:1982-1991.
2015
Moore JD, Rossi FM, Welsh MA, Nyffeler KE, Blackwell HE. A Comparative Analysis of Synthetic Quorum Sensing Modulators in Pseudomonas aeruginosa: New Insights into Mechanism, Active Efflux Susceptibility, Phenotypic Response, and Next-Generation Ligand Design. Journal of the American Chemical Society. 2015 ;137:14626-14639.
Kratochvil MJ, Tal-Gan Y, Yang T, Blackwell HE, Lynn DM. Nanoporous Superhydrophobic Coatings that Promote the Extended Release of Water-Labile Quorum Sensing Inhibitors and Enable Long-Term Modulation of Quorum Sensing in Staphylococcus aureus. ACS Biomater. Sci. Eng. 2015 ;1:1039-1049.
Eibergen NR, Moore JD, Mattmann ME, Blackwell HE. Potent and Selective Modulation of the RhlR Quorum Sensing Receptor by Using Non-native Ligands: An Emerging Target for Virulence Control in Pseudomonas aeruginosa. Chembiochem. 2015 ;16:2348-56.
Welsh MA, Eibergen NR, Moore JD, Blackwell HE. Small Molecule Disruption of Quorum Sensing Cross-Regulation in Pseudomonas aeruginosa Causes Major and Unexpected Alterations to Virulence Phenotypes. Journal of the American Chemical Society. 2015 ;137:1510-1519.
Gerdt JP, McInnis CE, Schell TL, Blackwell HE. Unraveling the contributions of hydrogen-bonding interactions to the activity of native and non-native ligands in the quorum-sensing receptor LasR. Organic & Biomolecular Chemistry. 2015 ;13:1453-1462.
2014
Moore JD, Gerdt JP, Eibergen NR, Blackwell HE. Active Efflux Influences the Potency of Quorum Sensing Inhibitors in Pseudomonas aeruginosa. Chembiochem. 2014 ;15:435-442.
Gerdt JP, Blackwell HE. Competition Studies Confirm Two Major Barriers That Can Preclude the Spread of Resistance to Quorum-Sensing Inhibitors in Bacteria. ACS Chemical Biology. 2014 ;9:2291-2299.
Gerdt JP, McInnis CE, Schell TL, Rossi FM, Blackwell HE. Mutational Analysis of the Quorum-Sensing Receptor LasR Reveals Interactions that Govern Activation and Inhibition by Nonlactone Ligands. Chemistry & Biology. 2014 ;21:1361-1369.
Tal-Gan Y, Stacy DM, Blackwell HE. N-Methyl and peptoid scans of an autoinducing peptide reveal new structural features required for inhibition and activation of AgrC quorum sensing receptors in Staphylococcus aureus. Chemical Communications. 2014 ;50:3000-3003.
Studer SV, Schwartzman JA, Ho JS, Geske GD, Blackwell HE, Ruby EG. Non-native acylated homoserine lactones reveal that LuxIR quorum sensing promotes symbiont stability. Environmental Microbiology. 2014 ;16:2623-2634.
McInnis CE, Blackwell HE. Non-native N-Aroyl (L)-Homoserine Lactones Are Potent Modulators of the Quorum Sensing Receptor RpaR in Rhodopseudomonas palustris. Chembiochem. 2014 ;15:87-93.
Palmer AG, Senechal AC, Mukherjee A, Ane JM, Blackwell HE. Plant Responses to Bacterial N-Acyl L-Homoserine Lactones are Dependent on Enzymatic Degradation to L-Homoserine. ACS Chemical Biology. 2014 ;9:1834-1845.
Broderick AH, Stacy DM, Tal-Gan Y, Kratochvil MJ, Blackwell HE, Lynn DM. Surface Coatings that Promote Rapid Release of Peptide-Based AgrC Inhibitors for Attenuation of Quorum Sensing in Staphylococcus aureus. Adv. Healthcare Mater. 2014 ;3:97-105.

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