All Faculty and Research Staff Publications

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2011
Yu Z, Zhao L-X, Jiang C-L, Duan Y, Wong L, Carver KC, Schuler LA, Shen B. Bafilomycins produced by an endophytic actinomycete Streptomyces sp YIM56209. Journal of Antibiotics. 2011 ;64:159-162.
Huang Y, Huang S-X, Ju J, Tang G, Liu T, Shen B. Characterization of the InmKLM Genes Unveiling Key Intermediates for beta-Alkylation in Leinamycin Biosynthesis. Organic Letters. 2011 ;13:498-501.
Galm U, Wendt-Pienkowski E, Wang L, Huang S-X, Unsin C, Tao M, Coughlin JM, Shen B. Comparative Analysis of the Biosynthetic Gene Clusters and Pathways for Three Structurally Related Antitumor Antibiotics: Bleomycin, Tallysomycin, and Zorbamycin. Journal of Natural Products. 2011 ;74:526-536.
Huang S-X, Yu Z, Robert F, Zhao L-X, Jiang Y, Duan Y, Pelletier J, Shen B. Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces sps. YIM56132 and YIM56141. Journal of Antibiotics. 2011 ;64:163-166.
Smanski MJ, Yu Z, Casper J, Lin S, Peterson RM, Chen Y, Wendt-Pienkowski E, Rajski SR, Shen B. Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 2011 ;108:13498-13503.
Chen Y, Yin M, Horsman GP, Shen B. Improvement of the Enediyne Antitumor Antibiotic C-1027 Production by Manipulating Its Biosynthetic Pathway Regulation in Streptomyces globisporus. Journal of Natural Products. 2011 ;74:420-424.
Yin M, Lu T, Zhao L-X, Chen Y, Huang S-X, Lohman JR, Xu L-H, Jiang C-L, Shen B. The Missing C-17 O-Methyltransferase in Geldanamycin Biosynthesis. Organic Letters. 2011 ;13:3726-3729.
Zhang Q, Li Y, Chen D, Yu Y, Duan L, Shen B, Liu W. Radical-mediated enzymatic carbon chain fragmentation-recombination. Nature Chemical Biology. 2011 ;7:154-160.
Liu S, Yu Z, Yu X, Huang S-X, Luo Y, Wu L, Shen W, Yang Z, Wang L, Gunawan AM, et al. SHP2 Is a Target of the Immunosuppressant Tautomycetin. Chemistry & Biology. 2011 ;18:101-110.
Shen B, Ikeda H. Special issue of The Journal of Antibiotics dedicated to the late Professor C Richard Hutchinson. Journal of Antibiotics. 2011 ;64:3-5.
Yu Z, Vodanovic-Jankovic S, Ledeboer N, Huang S-X, Rajski SR, Kron M, Shen B. Tirandamycins from Streptomyces sp 17944 Inhibiting the Parasite Brugia malayi Asparagine tRNA Synthetase. Organic Letters. 2011 ;13:2034-2037.
Yang D, Zhu X, Wu X, Feng Z, Huang L, Shen B, Xu Z. Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT-PCR. Applied Microbiology and Biotechnology. 2011 ;89:1709-1719.
2010
Chen Y, Wendt-Pienkowski E, Ju J, Lin S, Rajski SR, Shen B. Characterization of FdmV as an Amide Synthetase for Fredericamycin A Biosynthesis in Streptomyces griseus ATCC 43944. Journal of Biological Chemistry. 2010 ;285:38853-38860.
Lin S, Horsman GP, Shen B. Characterization of the Epoxide Hydrolase NcsF2 from the Neocarzinostatin Biosynthetic Gene Cluster. Organic Letters. 2010 ;12:3816-3819.
Huang S-X, Powell E, Rajski SR, Zhao L-X, Jiang C-L, Duan Y, Xu W, Shen B. Discovery and Total Synthesis of a New Estrogen Receptor Heterodimerizing Actinopolymorphol A from Actinopolymorpha rutilus. Organic Letters. 2010 ;12:3525-3527.
Ling J, Horsman GP, Huang S-X, Luo Y, Lin S, Shen B. Enediyne Antitumor Antibiotic Maduropeptin Biosynthesis Featuring a C-Methyltransferase That Acts on a CoA-Tethered Aromatic Substrate. Journal of the American Chemical Society. 2010 ;132:12534-12536.
Yu Z, Smanski MJ, Peterson RM, Marchillo K, Andes D, Rajski SR, Shen B. Engineering of Streptomyces platensis MA7339 for Overproduction of Platencin and Congeners. Organic Letters. 2010 ;12:1744-1747.
Luo Y, Li W, Ju J, Yuan Q, Peters NR, Hoffmann MF, Huang S-X, Bugni TS, Rajski S, Osada H, et al. Functional Characterization of TtnD and TtnF, Unveiling New Insights into Tautomycetin Biosynthesis. Journal of the American Chemical Society. 2010 ;132:6663-6671.
Powell E, Huang S-X, Xu Y, Rajski SR, Wang Y, Peters N, Guo S, H. Xu E, Hoffmann MF, Shen B, et al. Identification and characterization of a novel estrogenic ligand actinopolymorphol A. Biochemical Pharmacology. 2010 ;80:1221-1229.
Zhang N, Zhu X, Yang D, Cai J, Tao M, Wang L, Duan Y, Shen B, Xu Z. Improved production of the tallysomycin H-1 in Streptoalloteichus hindustanus SB8005 strain by fermentation optimization. Applied Microbiology and Biotechnology. 2010 ;86:1345-1353.
Chen Y, Smanski MJ, Shen B. Improvement of secondary metabolite production in Streptomyces by manipulating pathway regulation. Applied Microbiology and Biotechnology. 2010 ;86:19-25.
Schneider-Poetsch T, Ju J, Eyler DE, Dang Y, Bhat S, Merrick WC, Green R, Shen B, Liu JO. Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin. Nature Chemical Biology. 2010 ;6:209-217.
Wu X, Yang D, Zhu X, Feng Z, Lv Z, Zhang Y, Shen B, Xu Z. Iso-migrastatin Titer Improvement in the Engineered Streptomyces lividans SB11002 Strain by Optimization of Fermentation Conditions. Biotechnology and Bioprocess Engineering. 2010 ;15:664-669.
Chen Y, Yin M, Horsman GP, Huang S, Shen B. Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027. Journal of Antibiotics. 2010 ;63:482-485.
Rajski SR, Shen B. Multifaceted Modes of Action for the Glutarimide-Containing Polyketides Revealed. Chembiochem. 2010 ;11:1951-1954.
Yu Y, Guo H, Zhang Q, Duan L, Ding Y, Liao R, Lei C, Shen B, Liu W. NosA Catalyzing Carboxyl-Terminal Amide Formation in Nosiheptide Maturation via an Enamine Dealkylation on the Serine-Extended Precursor Peptide. Journal of the American Chemical Society. 2010 ;132:16324-16326.
Zhao C, Coughlin JM, Ju J, Zhu D, Wendt-Pienkowski E, Zhou X, Wang Z, Shen B, Deng Z. Oxazolomycin Biosynthesis in Streptomyces albus JA3453 Featuring an "Acyltransferase-less" Type I Polyketide Synthase That Incorporates Two Distinct Extender Units. Journal of Biological Chemistry. 2010 ;285:20097-20108.
Horsman GP, Chen Y, Thorson JS, Shen B. Polyketide synthase chemistry does not direct biosynthetic divergence between 9-and 10-membered enediynes. Proceedings of the National Academy of Sciences of the United States of America. 2010 ;107:11331-11335.
Shen B. Professor Emeritus C Richard Hutchinson (10 October 1943-5 January 2010) OBITUARY. Journal of Antibiotics. 2010 ;63:409-410.