All Faculty and Research Staff Publications

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Hackler A, Patrick SL, Kahney EW, Flaherty DP, Sharlow ER, Morris JC, Golden JE. Antiparasitic lethality of sulfonamidebenzamides in kinetoplastids. Bioorganic & Medicinal Chemistry Letters. 2017 ;27:755-758.
Adcock RS, Chu YK, Golden JE, Chung DH. Evaluation of anti-Zika virus activities of broad-spectrum antivirals and NIH clinical collection compounds using a cell-based, high-throughput screen assay. Antiviral Research. 2017 ;138:47-56.
Gordhan HM, Patrick SL, Swasy MI, Hackler AL, Anayee M, Golden JE, Morris JC, Whitehead DC. Evaluation of substituted ebselen derivatives as potential trypanocidal agents. Bioorganic & Medicinal Chemistry Letters. 2017 ;27:537-541.
Flaherty DP, Harris MT, Schroeder CE, Khan H, Kahney EW, Hackler AL, Patrick SL, Weiner WS, Aube J, Sharlow ER, et al. Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase1. Chemmedchem. 2017 ;12:1994-2005.
Gordhan HM, Milanes JE, Qiu YJ, Golden JE, Christensen KA, Morris JC, Whitehead DC. A targeted delivery strategy for the development of potent trypanocides. Chemical Communications. 2017 ;53:8735-8738.
Swingle M, Volmar CH, Saldanha SA, Chase P, Eberhart C, Salter EA, D'Arcy B, Schroeder CE, Golden JE, Wierzbicki A, et al. An Ultra-High-Throughput Screen for Catalytic Inhibitors of Serine/Threonine Protein Phosphatases Types 1 and 5 (PP1C and PP5C). Journal of Biomolecular Screening. 2017 ;22:21-31.
Chattopadhyay D, Swingle MR, Salter EA, Wood E, D'Arcy B, Zivanov C, Abney K, Musiyenko A, Rusin SF, Kettenbach A, et al. Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C. Biochemical Pharmacology. 2016 ;109:14-26.
Chung DH, Golden JE, Adcock RS, Schroeder CE, Chu YK, Sotsky JB, Cramer DE, Chilton PM, Song CS, Anantpadma M, et al. Discovery of a Broad-Spectrum Antiviral Compound That Inhibits Pyrimidine Biosynthesis and Establishes a Type 1 Interferon-Independent Antiviral State. Antimicrobial Agents and Chemotherapy. 2016 ;60:4552-4562.
Weisshaar M, Cox R, Morehouse Z, Kyasa SK, Yan D, Oberacker P, Mao SL, Golden JE, Lowen AC, Natchus MG, et al. Identification and Characterization of Influenza Virus Entry Inhibitors through Dual Myxovirus High-Throughput Screening. Journal of Virology. 2016 ;90:7368-7387.
Davis MI, Patrick SL, Blanding WM, Dwivedi V, Suryadi J, Golden JE, Coussens NP, Lee OW, Shen M, Boxer MB, et al. Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity. Antimicrobial Agents and Chemotherapy. 2016 ;60:6023-6033.
Lopez-Sambrooks C, Shrimal S, Khodier C, Flaherty DP, Rinis N, Charest JC, Gao NG, Zhao P, Wells L, Lewis TA, et al. Oligosaccharyltransferase inhibition induces senescence in RTK-driven tumor cells. Nature Chemical Biology. 2016 ;12:1023-+.
Schroeder CE, Neuenswander SA, Yao T, Aube J, Golden JE. One-pot, regiospecific assembly of (E)-benzamidines from delta- and gamma-amino acids via an intramolecular aminoquinazolinone rearrangement. Organic & Biomolecular Chemistry. 2016 ;14:3950-3955.
Schroeder CE, Yao TL, Sotsky J, Smith RA, Roy S, Chu YK, Guo HX, Tower NA, Noah JW, McKellip S, et al. Development of (E)-2-((1,4-Dimethylpiperazin-2-ylidene)amino)-5-nitro-N-phenylbenzamide , ML336: Novel 2-Amidinophenylbenzamides as Potent Inhibitors of Venezuelan Equine Encephalitis Virus. Journal of Medicinal Chemistry. 2014 ;57:8608-8621.
Chung DH, Jonsson CB, Tower NA, Chu YK, Sahin E, Golden JE, Noah JW, Schroeder CE, Sotsky JB, Sosa MI, et al. Discovery of a Novel Compound with Anti-Venezuelan Equine Encephalitis Virus Activity That Targets the Nonstructural Protein 2. Plos Pathogens. 2014 ;10:10.
Flaherty DP, Miller JR, Garshott DM, Hedrick M, Gosalia P, Li YJ, Milewski M, Sugarman E, Vasile S, Salaniwal S, et al. Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response. Acs Medicinal Chemistry Letters. 2014 ;5:1278-1283.
Wender PA, Axtman AD, Golden JE, Kee JM, Sirois LE, Quiroz RV, Stevens MC. Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors. Organic Chemistry Frontiers. 2014 ;1:1166-1171.
Matharu DS, Flaherty DP, Simpson DS, Schroeder CE, Chung D, Yan D, Noah JW, Jonsson CB, White EL, Aube J, et al. Optimization of Potent and Selective Quinazolinediones: Inhibitors of Respiratory Syncytial Virus That Block RNA-Dependent RNA-Polymerase Complex Activity. Journal of Medicinal Chemistry. 2014 ;57:10314-10328.
Flaherty DP, Simpson DS, Miller M, Maki BE, Zou BY, Shi J, Wu M, McManus OB, Aube J, Li M, et al. Potent and selective inhibitors of the TASK-1 potassium channel through chemical optimization of a bis-amide scaffold. Bioorganic & Medicinal Chemistry Letters. 2014 ;24:3968-3973.
Agola JO, Hong L, Surviladze Z, Ursu O, Waller A, Strouse JJ, Simpson DS, Schroeder CE, Oprea TI, Golden JE, et al. A Competitive Nucleotide Binding Inhibitor: In Vitro Characterization of Rab7 GTPase Inhibition. ACS Chemical Biology. 2012 ;7:1095-1108.
Seguin SP, Evans CW, Nebane-Akah M, McKellip S, Ananthan S, Tower NA, Sosa M, Rasmussen L, White EL, Maki BE, et al. High-Throughput Screening Identifies a Bisphenol Inhibitor of SV40 Large T Antigen ATPase Activity. Journal of Biomolecular Screening. 2012 ;17:194-203.
Chen J, Young SM, Allen C, Seeber A, Peli-Gulli MP, Panchaud N, Waller A, Ursu O, Yao TL, Golden JE, et al. Identification of a Small Molecule Yeast TORC1 Inhibitor with a Multiplex Screen Based on Flow Cytometry. ACS Chemical Biology. 2012 ;7:715-722.
Frohn M, Cee VJ, Lanman BA, Pickrell AJ, Golden JE, Rivenzon-Segal D, Middleton S, Fiorino M, Xu H, Schrag M, et al. Novel 5-and 6-subtituted benzothiazoles with improved physicochemical properties: Potent S1P(1) agonists with in vivo lymphocyte-depleting activity. Bioorganic & Medicinal Chemistry Letters. 2012 ;22:628-633.
Moore BP, Chung DH, Matharu DS, Golden JE, Maddox C, Rasmussen L, Noah JW, Sosa MI, Ananthan S, Tower NA, et al. (S)-N-(2,5-Dimethylphenyl)-1-(quinoline-8-ylsulfonyl)pyrrolicline-2-carb oxamide as a Small Molecule Inhibitor Probe for the Study of Respiratory Syncytial Virus Infection. Journal of Medicinal Chemistry. 2012 ;55:8582-8587.
Lei Y, Wrobleski AD, Golden JE, Powell DR, Aube J. Facile C-N cleavage in a series of bridged lactams. Journal of the American Chemical Society. 2005 ;127:4552-4553.