UW Madison Chemistry Newsletter for 01/26/2015

Bucky UNIVERSITY OF WISCONSIN-MADISON
DEPARTMENT OF CHEMISTRY NEWSLETTER
XXXIX - No. 3 January 26th, 2015

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2014-15 Dates of Finance/Department Meetings
Department/Executive Committee Meetings - Tuesdays - 1:30 PM - Room 9341 Chemistry

Feb 10, 2015 Mar 10, 2015 Apr 14, 2015 May 12, 2015

Finance Committee Meetings - Tuesdays - 1:30 PM - Room 1130

Feb 3, 2015 Feb 17, 2015 Mar 3, 2015 Mar 17, 2015
Apr 7, 2015 Apr 21, 2015 May 5, 2015 May 26, 2015

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SEMINARS
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Wednesday, January 28th, 2015 - Inorganic, Materials, Organic Seminar, 3:30 pm, Room 1315 Chemistry. Prof. Christophe Coperet, Swiss Federal Inst. of Technology "Meloche Lecture - Controlled Surface Functionalization Towards Single-Site Catalysts"
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Friday, January 30th, 2015 - Department Seminar, 12:00 pm, Room 9341 Chemistry Building. Dr. Cheri Barta, UW-Madison Department of Chemistry "Research Mentoring Workshop Series: Establishing Expectations"
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Friday, January 30th, 2015 - Inorganic Seminar, 3:30 pm, Room 1315 Chemistry. Prof. Christophe Coperet, Swiss Federal Inst. of Technology "Meloche Lecture: NMR, a Tool Towards a Molecular Level Understanding of Surface Structures, Active Sites and Beyond"
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Saturday, January 31st, 2015 - General Outreach, 9:00 am, "Wisconsin Middle School Regional Science Bowl"
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Monday, February 2nd, 2015 - Inorganic, Materials Seminar, 3:30 pm, 1315 Chemistry (Seminar Hall). Prof. Theresa Reineke, University of Minnesota "Sugar-coated polymer synthesis: from sustainable materials to selective drug delivery"
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Tuesday, February 3rd, 2015 - Graduate, Physical, Theoretical Seminar, 11:00 am, Room 1315 Chemistry Building (Seminar Hall). Professor John Herbert, Ohio State University "Novel Quantum Chemistry Methods for Large Systems: From Non-Covalent Assemblies to Excited-State Energy Transfer"
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Tuesday, February 3rd, 2015 - Organic Seminar, 3:30 pm, 1315 Chemistry. Professor John Reynolds, Georgia Institute of Technology "Organic Seminar "Color in Conjugated Polymers: Electrochromism and Photovoltaics""
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Wednesday, February 4th, 2015 - Inorganic Seminar, 3:30 am, Room 1315 Chemistry. Travis Sunderland, UW-Madison, Berry Group "Inorganic Seminar"
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Wednesday, February 4th, 2015 - General Seminar, 12:00 pm, 1211 Biochemical Sciences Bldg. Srivatsan Raman, Harvard University "Design and Evolution of New Proteins and Genomes"
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Thursday, February 5th, 2015 - Inorganic Seminar, 11:00 am, Room 1315 Chemistry. Tristan Brown, UW-Madison, Berry Group "Inorganic Seminar"
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Thursday, February 5th, 2015 - Analytical, Chemical Biology Seminar, 12:15 pm, 1315 Chemistry (Seminar Hall). Matthew Champion, University of Notre Dame "A proteomics lens on the molecular biology of bacterial pathogens"
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Friday, February 6th, 2015 - Department Seminar, 12:00 pm, Room 8335 Chemistry Building. Dr. Cheri Barta, UW-Madison Department of Chemistry "Research Mentoring Workshop Series: Maintaining Effective Communication"
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Monday, February 9th, 2015 - Materials Seminar, 3:30 pm, 1315 Chemistry (Seminar Hall). Prof. Yuriy Roman, MIT Chemical Engineering "Materials Seminar"
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Tuesday, February 10th, 2015 - Graduate, Physical, Theoretical Seminar, 11:00 am, Room 1315 Chemistry Building (Seminar Hall). Professor David Ginger, University of Washington "Physical Chemistry Seminar"
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Wednesday, February 11th, 2015 - General Seminar, 11:00 am, 1211 Biochemical Sciences Bldg. Joshua Michener, MIT "Evolutionary Optimization of Heterologous Pathways in Microbes"
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Wednesday, February 11th, 2015 - Organic Seminar, 3:30 pm, 1315 Chemistry. Professor Ryan Shenvi, Scripps Research Institute "Organic Seminar "Chemical Synthesis of Secondary Metabolites""
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Thursday, February 12th, 2015 - Analytical, Materials Seminar, 12:15 pm, 1315 Chemistry (Seminar Hall). Jodi Cabana, University of Illinois, Chicago "Visualization of Electrochemical Phase Transformations in Battery Materials with Synchrotron X-ray"
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Monday, February 16th, 2015 - General Seminar, 1:00 pm, 1211 Biochemical Sciences Bldg. Jerome Fox, Harvard University "Kinetic Impediments as Targets for Optimization and Control in Complex Systems: from Biofuels to Forest Fires"
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Monday, February 16th, 2015 - Department, Graduate, Physical, Theoretical Seminar, 3:00 pm, Room 9341 Chemistry Building. Professor Nandini Ananth, Cornell University "TCI Seminar"
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Monday, February 16th, 2015 - Materials Seminar, 3:30 pm, 1315 Chemistry (Seminar Hall). Prof. Jillian Buriak, University of Alberta, Canada "Materials Seminar"
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Tuesday, February 17th, 2015 - Graduate, Physical, Theoretical Seminar, 11:00 am, Room 1315 Chemistry Building (Seminar Hall). "Physical Chemistry Seminar"
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Tuesday, February 17th, 2015 - Organic Seminar, 3:30 pm, 1315 Chemistry. Professor Abigail Doyle, Princeton "Organic Seminar "New Electrophiles and Ligands for Ni-Catalyzed Cross Coupling""
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Wednesday, February 18th, 2015 - General Seminar, 11:00 am, 1211 Biochemical Sciences Bldg. Michaela TerAvest, UC-Berkeley "Dissection and Redesign of the Bacterial Respiratory Powerhouse for Synthetic Biology"
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Thursday, February 19th, 2015 - Analytical, Chemical Biology Seminar, 12:15 pm, 1315 Chemistry (Seminar Hall). Kevin Eliceira, University of wisconsin Microscopy Center "Analytical Seminar (Title TBA)"
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Thursday, February 19th, 2015 - General, Graduate Special Event, 4:30 pm, Chemistry 1381 (Graduate Computer Lab). Ariel Andrea, Chemistry Librarian, UW-Madison "Intermediate/Advanced EndNote Workshop"
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Monday, February 23rd, 2015 - General Seminar, 12:00 pm, 1211 Biochemical Sciences Bldg. Alison Narayan, University of Michigan "Chemical and Enzymatic Methods for the Synthesis of Complex Molecules"
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Tuesday, February 24th, 2015 - Graduate, Physical, Theoretical Seminar, 11:00 am, Room 1315 Chemistry Building (Seminar Hall). Professor Anastassia Alexandrova, University of California-Los Angeles "Sub-nano clusters: motors, catalysts, and simply curious entities"
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Wednesday, February 25th, 2015 - General Seminar, 11:00 am, Ebling Auditorium of Microbial Sciences Bldg. Russell Monds, Synthetic Genomics "Evolution of the Bacterial Cytoskeleton and Principles of Cellular Design"
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Wednesday, February 25th, 2015 - Department, Inorganic Seminar, 3:30 pm, Room 1315 Chemistry. Dr. David Anderson, BASF "Seminar"
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Thursday, February 26th, 2015 - Organic Seminar, 11:00 am, 1315 Chemistry. Professor Ming Hammond, UC-Berkeley "Organic Seminar"
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Thursday, February 26th, 2015 - Department Colloquium, 3:30 pm, 1315 Chemistry Building (Seminar Hall). Professor Robert Langer, Massachusetts Institute of Technology "Shain Colloquium: Biomaterials and Biotechnology"
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Friday, February 27th, 2015 - Department Seminar, 12:00 pm, Room 9341 Chemistry Building. Dr. Cheri Barta, UW-Madison Department of Chemistry "Research Mentoring Workshop Series: Fostering Independence"
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Friday, February 27th, 2015 to Sunday, March 1st, 2015 - Department Special Event, 4:00 pm, "Graduate Recruiting Visit Weekend"
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Tuesday, March 3rd, 2015 - Graduate, Physical, Theoretical Seminar, 11:00 am, Room 1315 Chemistry Building (Seminar Hall). "Physical Chemistry Seminar"
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Thursday, March 5th, 2015 - Analytical Lecture, 12:15 pm, 1315 Chemistry. Prof. Lan Yang, Washington University "Whispering-gallery microresonators and microlasers for nanoscale sensing and beyond"
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Friday, March 6th, 2015 - Department Seminar, 12:00 pm, Room 9341 Chemistry Building. Dr. Cheri Barta, UW-Madison Department of Chemistry "Research Mentoring Workshop Series: Solving Mentoring Challenges"
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Monday, March 9th, 2015 - Department, Graduate, Physical, Theoretical Seminar, 3:00 pm, Room 9341 Chemistry Building. Professor Christopher Fennell, Oklahoma State University "Effective electrolytes: Generalizing collective interactions in solution"
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Monday, March 9th, 2015 - Materials Seminar, 3:30 pm, 1315 Chemistry (Seminar Hall). Professor Bryan Boudouris, Purdue University "Designing Macromolecules for Advanced Energy Conversion and Nanofiltration Applications"
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Tuesday, March 10th, 2015 - Department, Graduate, Physical Seminar, 11:00 am, Room 1315 Chemistry Building (Seminar Hall). Professor Timothy Zwier, Purdue University "Physical Chemistry Seminar"
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Wednesday, March 11th, 2015 - Inorganic Seminar, 3:30 pm, Room 1315 Chemistry. Julia Wildt, UW-Madison, Landis Group "Seminar"
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Wednesday, March 11th, 2015 - General Special Event, 7:00 pm, 1315 Chemistry Building (Seminar Hall). WISL / School of Music, UW-Madison "Rameau the Theorist"
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Thursday, March 12th, 2015 - Organic Seminar, 11:00 am, 1315 Chemistry Building (Seminar Hall). Catherine Jackson, UW-Madison "Organic Seminar"
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Thursday, March 12th, 2015 - Analytical, Chemical Biology Seminar, 12:15 pm, 1315 Chemistry (Seminar Hall). Alicia Richards, UW-Madison Joshua Coon Group "Analytical Seminar (Title TBA)"
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Friday, March 13th, 2015 - Department Seminar, 3:30 pm, 1315 Chemistry Building (Seminar Hall). Professor Leiv Sydnes, University of Bergen (Norway) "Chemistry in Service to Humanity and Earth"
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Tuesday, March 17th, 2015 - Graduate, Physical, Theoretical Seminar, 11:00 am, Room 1315 Chemistry Building (Seminar Hall). Professor Pupa Gilbert, University of Wisconsin-Madison "Physical Chemistry Seminar"
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Thursday, March 19th, 2015 - Organic Seminar, 11:00 am, 1315 Chemistry. Professor Matthew Gaunt, University of Cambridge UK "Organic AbbVie Seminar"
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Sunday, March 22nd, 2015 - Department Special Event, 5:00 pm, UW-Madison Department of Chemistry, "Department Reception at ACS National Meeting (Denver)"
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Wednesday, March 25th, 2015 - Inorganic Seminar, 3:30 pm, Room 1315 Chemistry. Brandon Kilduff, UW-Madison, Fredrickson Group "Seminar"
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Friday, March 27th, 2015 to Sunday, March 29th, 2015 - Department Special Event, 4:00 pm, "Graduate Recruiting Visit Weekend"
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BRAINIAC BOWL 2015
Saturday, February 28th, 5:30 - 9:00
You are hereby cordially invited to the Aldo Leopold Nature Center's upcoming Brainiac Bowl 2015.  This awesome event is scheduled for Saturday, February 28, 2015 and is being hosted by CUNA Mutual.  This is a great chance to reward your hard working staff, grad students and yourself while engaging in some fun competition and leadership and team building skills. Plus it is a great way to beat the late winter doldrums and build student morale! We have some great teams already signed up, including: CUNA Mutual, Aldo Leopold Foundation, The Burish Group, Phoenix Nuclear, The Great Dane, Skogen Engineering, Foley & Lardner, and some teams of individuals intellects just to name a few. While this event is $125/person or $1,000 per table of eight, we are offering the UW Madison staff and students a $200 discount on a table.  Please let us know if we can count your team as one to be reckoned with in 2015. Plus, if you recruit another team--from your department, another department or individuals - we can give you an additional $50 discount on your table.  Come for the comradery and compete to take home the championship "pulsating" Brain trophy to class up your department. Recruiting another team is easy.  Just forward the e-invite to your departmert rivals and family and friends, and taunt them to take the Brainiac Bowl challenge with you.  If you are too chicken to participate, we would appreciate it if you would forward the e-invite on to anyone you think might enjoy a little intellectual jousting. For more information and to sign up, please contact Kelley Van Egeren at 216-9373 or Kelley@naturenet.com. We hope to hear from you soon saying you are up to the Brainiac Bowl challenge!
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INVITATION TO PARTICIPATE IN CAMPUS-WIDE DISCUSSIONS ON THE BIOMEDICAL WORKFORCE
We invite you to participate in a series of campus-wide discussions in late February and throughout March with the goal of finding solutions to the systemic flaws in US biomedical research, flaws that were described in a 2014 PNAS article. These discussions will culminate in an April workshop entitled "Rescuing US Biomedical Research from its Systemic Flaws: Strategies and Pathways Ahead". The website for this campus wide effort is: https://research.wisc.edu/biomedworkforce/.
February launch: The Chancellor will launch these discussions on February 16 at 1pm in room 165, Bascom Hall. We encourage all interested members of the UW-Madison research community to attend this launch, which will include brief summaries of problems articulated by the PNAS article and goals of our March discussions.
March pre-workshop discussions. Teams from a range of career stages and from four different colleges (L&S, CALS, SMPH and Engineering) will lead discussions on the key issues to vet ideas for solutions. You are invited to attend any or all of these March pre-workshop sessions to learn more about the issues and, most importantly, to voice your own opinions.
Numbers in the Biomedical Research Workforce. How should the pipeline change to reduce the number of independent investigators who compete for research funding?
     •    March 3, 2-4 pm. Ebling Auditorium, Microbial Sciences Building
     •    March 5, 4-6 pm. Health Sciences Learning Center, Room 1335
Shape of the Biomedical Research Workplace. How should university policies, departments and laboratories change to accommodate fewer governmental funds available to maintain them?
     •    March 10, 2-4 pm. Ebling Auditorium, Microbial Sciences Building
     •    March 12, 4-6 pm. Health Sciences Learning Center, Room 1335
NIH Grant Mechanisms. What types of grants or grant policies should be introduced or changed to increase funding available to young and mid-career investigators?
     •    March 17, 2-4 pm. Ebling Auditorium, Microbial Sciences Building
     •    March 19, 4-6 pm. Health Sciences Learning Center, Room 1335
NIH Evaluation Mechanisms. How should peer review be reconfigured to increase funding for proposals with potential for groundbreaking advances?
     •    March 24, 2-4 pm. Ebling Auditorium, Microbial Sciences Building
     •    March 26, 4-6 pm. Health Sciences Learning Center, Room 1335
APRIL 11, 2015 WORKSHOP (DeLuca Forum WID, 8 am - 5 pm). The major ideas generated in March pre-workshop discussions will be presented and discussed at a workshop in April with outside guests, including two PNAS co-authors (Alberts and Tilghman). Attendance at the workshop will be limited in number and open on a first come first serve basis. The workshop will be recorded for those not able to attend; a workshop report will be presented in May 2015 at a national conference at the University of Michigan and will also seed strategy planning for the UW-Madison campus.
We hope that you are excited about the opportunity afforded by the upcoming discussions and can participate actively. Please join us in this crucial conversation.
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BIODESIGN BIOCATALYSIS
UW-Madison Seminar Series - Sponsored by Wisconsin Energy Institute
A series of cutting-edge seminars in two exciting and rapidly growing areas of the Biosciences by faculty candidates at UW-Madison.
Srivatsan Raman Harvard U - "Design and Evolution of New Proteins and Genomes". Noon Wednesday Feb 4 - 1211 Biochemical Sciences Bldg.
Joshua Michener MIT. - "Evolutionary Optimization of Heterologous Pathways in Microbes", 11 am Wednesday Feb 11 - 1211 Biochemical Sciences Bldg
Jerome Fox Harvard U - "Kinetic Impediments as Targets for Optimization and Control in Complex Systems: from Biofuels to Forest Fires" 1 pm Monday Feb 16 - 1211 Biochemical Sciences Bldg.
Michaela TerAvest UC Berkeley - "Dissection and Redesign of the Bacterial Respiratory Powerhouse for
Synthetic Biology" 11 am Wednesday Feb 18 - 1211 Biochemical Sciences Bldg.
Alison Narayan U Michigan - "Chemical and Enzymatic Methods for the Synthesis of Complex Molecules" Noon - Monday Feb 23   1211 Biochemical Sciences Bldg.
Russell Monds Synthetic Genomics - "Evolution of the Bacterial Cytoskeleton and Principles of Cellular Design" - 11 am Wednesday Feb 25   Ebling Aud   Microbial Sciences Bldg.
The Biodesign Biocatalysis seminar series will be presented by faculty candidates in a UW cluster hire search. Times and locations, but not dates, of some later seminars may change. If you are interested in meeting with one of the visiting candidates, please contact Kylie Maxcy (890-2416; kmaxcy@glbrc.wisc.edu).
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RECENT PUBLICATIONS
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Relative quantification of amine-containing metabolites using isobaric N,N-dimethyl leucine (DiLeu) reagents via LC-ESI-MS/MS and CE-ESI-MS/MS.
Hao, L; Zhong, XF; Greer, T; Ye, H; Li, LJ*.
ANALYST, 140 (2):467-475; 10.1039/c4an01582g 2015.
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O-2-promoted allylic acetoxylation of alkenes: Assessment of "push" versus "pull" mechanisms and comparison between O-2 and benzoquinone.
Diao, TN; Stahl, SS*.
POLYHEDRON, 84 96-102; SI 10.1016/j.poly.2014.06.038 DEC 14 2014.
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Infrared spectral marker bands characterizing a transient water wire inside a hydrophobic membrane protein.
Wolf, S; Freier, E; Cui, Q*; Gerwert, K.
JOURNAL OF CHEMICAL PHYSICS, 141 (22):10.1063/1.4902237 DEC 14 2014.
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Theoretical vibrational sum-frequency generation spectroscopy of water near lipid and surfactant monolayer interfaces. II. Two-dimensional spectra.
Roy, S; Gruenbaum, SM; Skinner, JL*.
JOURNAL OF CHEMICAL PHYSICS, 141 (22):10.1063/1.4895968 DEC 14 2014.
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Coupled States in Dinitrofluorene: Relationships between Ground State and Excited State Mixed Valence.
Kiesz, MD; Hoekstra, RM; Chen, YT; Telo, JP; Nelsen, SF*; Zink, JI.
JOURNAL OF PHYSICAL CHEMISTRY A, 118 (49):11490-11498; 10.1021/jp505299p DEC 11 2014.
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Gated Hall Effect of Nanoplate Devices Reveals Surface-State-Induced Surface Inversion in Iron Pyrite Semiconductor.
Liang, D; Caban-Acevedo, M; Kaiser, NS; Jin, S*.
NANO LETTERS, 14 (12):6754-6760; 10.1021/nl501942w DEC 2014.
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Recent advances in enrichment and separation strategies for mass spectrometry-based phosphoproteomics.
Yang, CX; Zhong, XF; Li, LJ*.
ELECTROPHORESIS, 35 (24):3418-3429; SI 10.1002/elps.201400017 DEC 2014.
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Multifaceted Investigation of Metabolites During Nitrogen Fixation in Medicago via High Resolution MALDI-MS Imaging and ESI-MS.
Gemperline, E; Jayaraman, D; Maeda, J; Ane, JM; Li, LJ*.
Journal of the American Society for Mass Spectrometry, 26 (1):149-158; 10.1007/s13361-014-1010-0 JAN 2015.
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Novel isotopic N,N-Dimethyl Leucine (iDiLeu) Reagents Enable Absolute Quantification of Peptides and Proteins Using a Standard Curve Approach.
Greer, T; Lietz, CB; Xiang, F; Li, LJ*.
Journal of the American Society for Mass Spectrometry, 26 (1):107-119; 10.1007/s13361-014-1012-y JAN 2015.
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Signals from the surface modulate differentiation of human pluripotent stem cells through glycosaminoglycans and integrins.
Wrighton, PJ; Klim, JR; Hernandez, BA; Koonce, CH; Kamp, TJ; Kiessling, LL*.
Proceedings of the National Academy of Sciences of the United States of America, 111 (51):18126-18131; 10.1073/pnas.1409525111 DEC 23 2014.
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Ionization of High-Density Deep Donor Defect States Explains the Low Photovoltage of Iron Pyrite Single Crystals.
Caban-Acevedo, M; Kaiser, NS; English, CR; Liang, D; Thompson, BJ; Chen, HE; Czech, KJ; Wright, JC*; Hamers, RJ*; Jin, S*.
Journal of the American Chemical Society, 136 (49):17163-17179; 10.1021/ja509142w DEC 20 2014.
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Copyright © 2015 Thomson ISI
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EMPLOYMENT OPPORTUNITIES
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NONE FOR THIS NEWSLETTER
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FACULTY POSITIONS/TEMPORARY FACULTY/ACADEMIC POSITIONS
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The University of Louisiana at Lafayette, Ray P. Authement College of Sciences, Department of Chemistry invites applications for a tenure track position in Analytical Chemistry at the Assistant Professor level. The successful candidate will teach analytical, general chemistry, instrumental analysis and the associated laboratories. The chemist is expected to teach, perform research, and participate fully in other activities of our ACS-Certified department, college, and university. Consistent with these responsibilities, the successful candidate will have a Ph.D. in analytical chemistry, research, and postdoctoral experience preferred. A vita, transcripts, teaching philosophy, research plan, and three letters of recommendation should be directed to: Dr. Wu Xu, Chairman, Search Committee, Department of Chemistry, P.O. Box 44370, University of Louisiana at Lafayette, Lafayette, Louisiana 70504-4370, or email: wxx6941@louisiana.edu.
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The University of California-Riverside is seeking candidates for a faculty opening in bioanalytical chemistry at UC Riverside. We are reopening the search next week. UC Riverside has a strong group of bioanalytical chemists and a new school of medicine (in its second year). The campus plans to add 300 new faculty over the next 5 years, most of whom will be in science, engineering and medicine. It would be an exciting place for someone to build their career. Information about the positions can be found at: http://chem.ucr.edu/news/general_news/faculty_position.html. Contact: Cynthia K. Larive, Ph.D., Professor of Chemistry, Divisional Dean for Chemistry, Mathematics, and Physics & Astronomy, University of California - Riverside, Riverside, CA 92521, Phone: 951-827-2990.
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The University of Toledo. Chair, Department of Chemistry and Biochemistry. Applications are sought for an exceptional individual to join the faculty at the tenured rank of associate or full professor and serve as department chair as of July 1, 2015. The successful candidate is expected to have an outstanding record of teaching and research accomplishments in any area of chemistry or biochemistry. The new chair will be expected to be a visionary leader to build on the department's strengths in teaching and research, expand external and inter-disciplinary programs, and foster the growth of the new School of Green Chemistry and Engineering.
The University of Toledo (www.utoledo.edu) was founded in 1872 and is a comprehensive state institution with over 20,000 students. The University has 12 academic colleges and professional programs located on a suburban main campus and a separate health sciences campus, home to the medical college. The chair oversees an enrollment of 5000 undergraduate and graduate students in chemistry classes each semester, including 125 B.A. and B.S. majors and 75 graduate students in M.S. and Ph.D. programs. The B.S. degrees in chemistry and biochemistry are certified by the American Chemical Society. The department (www.utoledo.edu/nsm/chemistry) has 25 faculty members and a support staff of 12, including a master glassblower, 5 instrumentation and electronics specialists, and 3 stockroom personnel.
The Chair is the chief administrative officer of the department and reports to the College Dean. The Chair is responsible for successful planning, organization, policy development, implementation and direction of all aspects of the department, including personnel management within the unit. The Chair is expected to ensure that students have a high quality experience that exemplifies the values of the institution. The chair also is expected to manage the resources of the department in a fiscally responsible manner through compliance with the University's budgetary process. Further elaboration of responsibilities is outlined in university policy #3364-72-05 (www.utoledo.edu/policies).
The University offers competitive salaries and excellent start-up and benefits packages. Qualified applicants must have a Ph.D. in Chemistry or related field. Applicants must submit as a single pdf file to: https://jobs.utoledo.edu, which should include a cover letter describing a vision for departmental leadership and your qualifications for that role, a current curriculum vitae, a summary of past research and teaching accomplishments and future directions, and a list of three references who are able to address your qualifications for the position.
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POSTDOCTORAL POSITIONS AND/OR JOBS
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Novilytic Post-Doctoral Position.
Job Title: Diagnostic Development Scientist
Duration: Two years
Reports to: Dr. Fred Regnier
Department: Research & Development
Address: Kurz Purdue Technology Center (KPTC), 1281 Win Hentschel Blvd. West Lafayette, IN 47906.
Email: fregnier@novilytic.com; fregnier@purdue.edu.
Phone: 765-404-0780
Position Overview: This Post-Doctoral position will focus on the development of a disposable, capillary action driven microfluidic membrane system for clinical diagnostics involving blood collection, plasma extraction from a drop of finger-stick derived blood, immune complex formation on nanoparticulate affinity sorbents, isotopically labeled internal standard addition, and chemical modification reactions; all within the membrane stack.  A major focus of this work is to develop systems capable of totally preparing biological extracts for ESI-MS/MS and MALDI-MS/MS analysis without i) human intervention or ii) a source of energy during blood collection and transport to an analytical laboratory.  This work will culminate in the application of this technology to diagnostic problems through collaborations with established clinical laboratories.
Mentor: Supervision will be provided by Dr. Regnier. Qualifications, Skills & Attributes:
     •    Education:  Ph.D. with a focus on analytical chemistry or biochemistry.  
     •    Work Experience:  None required.
     •    Skills:  Experience with common analytical instrumentation; ability to interpret MS, NMR and IR
          spectra; some experience of organic, or inorganic synthesis.  This individual should also have good
          interpersonal skills, an aptitude for organizational and time-management, and the ability to handle
          multiple tasks simultaneously. Being able to assume substantial responsibility while working
          independently and having a strong desire to be successful is assumed.   
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The California Institute for Biomedical Research (Calibr) is looking for talented post-doctoral fellows interested in medicinal chemistry and translational research to join our team.  Calibr is a not for profit biomedical research institute focused on developing innovative new medicines for unmet needs- from regenerative medicines to drugs for neglected diseases and cancer. In the last 2.5 years the Institute has grown to ~120 scientists, most of whom are post-docs providing key scientific input on a wide range of areas (oral small molecules, cell-targeted and tissue-localized small molecules, therapeutic peptides, antibody-drug conjugates, protein fusions and cell therapies).  The medicinal chemistry group has grown, and now consists of 17 post-docs, and two principal investigators.  The chemistry team at Calibr has already made a large impact on the organization, contributing to the identification of 8 small molecules which have demonstrated preclinical proof of concept. We have established all the key tools for doing preclinical drug discovery (high throughput screening with a ~1M compound library, modern medicinal chemistry, cell biology, protein chemistry, and pharmacology) and provide an opportunity for post-docs to champion several projects in parallel to learn as much drug discovery chemistry/biology/pharmacology as possible within a relatively short period of time. We currently have 20+ projects that are in animal models and have been able to move several projects into the preclinical candidate stage (among them novel compounds for fibrosis, TB, arthritis and MS). Indeed we are in active partnering discussions with pharma/biotech, foundations and philanthropists to move these programs quickly to the clinic (we hope to progress multiple programs to Ph1/PoC studies this year and next). In addition we have collaborations with Merck, BMS, JDRF, the Wellcome Trust, CSMA and the Bill and Melinda Gates Foundation, as well as many leading academic labs around the world. Calibr provides a unique environment for hands-on preclinical drug discovery/chemical biology experience in a dynamic environment with considerable guidance from outstanding PIs. For anyone contemplating a career in translational research this would be terrific experience. Contact: Peter Schultz (schultz@calibr.org).
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Please submit all newsletter information or address changes to: goldade@chem.wisc.edu or 262-0293. Thanks.
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DETAILS ARE AVAILABLE IN ROOM 1146.
NEXT NEWSLETTER IS ON JANUARY 26th, 2015