Chemistry Newsletter 6/29/2009

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XXXIII - No. 21 June 29th, 2009

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Some Sad News
Ralph Hirschmann, who earned his PhD in our department in 1950, died June 20 in Lansdale, PA. He was 87. Hirschmann was an organic chemist whose long career included many contributions to the chemistry and biology of anti-inflammatory steroids; to synthetic methods in peptide chemistry; to elucidating the chemistry, biology, and structure activity relationships of hypothalamic releasing factors, especially somatostatin and TRH; to the design and synthesis of numerous pharmaceuticals; and to the field of peptidomimetics.
Hirschmann and R.G. Denkewalter led the Merck & Co. team that achieved the first in-vitro synthesis of an enzyme, ribonuclease S'. This total synthesis in solution, along with Merrifield's on solid support, demonstrated that the amino acid sequence of a small protein such as ribonuclease A determines its tertiary structure in aqueous medium. This major achievement received worldwide front page coverage in 1969.
In 1971 Hirschmann became the head of the Department of New Lead Discovery at Merck and in 1978 he was named Senior Vice President for Basic Research in Chemistry at the Merck Research Laboratories. During his tenure as head of Basic Research at Merck, his teams discovered and/or developed many widely used medicines important for the treatment of infectious diseases, hypertension, and hyperlipidemia. These included Vasotec, Lisinopril, Primaxin, Mevacor, Proscar, and Ivomec. The antiparasitic drug Ivomec all but eradicated river blindness, a dreaded disease of the developing world. It is also widely used in the treatment of roundworm in livestock and the prevention of heartworm in dogs.
In 1987, after his mandatory retirement from Merck at the age of 65, Hirschmann started a second career at the University of Pennsylvania where he served as the Rao Makineni Professor of Bioorganic Chemistry. During his nearly six highly productive decades as a chemist, he was inventor or co-inventor on over 100 patents and authored or co-authored approximately 200 publications.
In 2000 he received the country's highest scientific award from President Clinton: The National Medal of Science. In 2007 he was inducted into the American Chemical Society's Medicinal Chemistry Hall of Fame. His research was also recognized with many other awards and honors including the Nichols Medal, the Alfred Burger Award, the Arthur C. Cope Medal, and the Willard Gibbs Medal. Dr. Hirschmann was elected a member of the American Academy of Arts and Sciences, the National Academy of Sciences, and a Senior Fellow of the Institute of Medicine of the National Academies.
A native of Fürth, Bavaria, Germany, Hirschmann immigrated to the United States in 1937 and became a US citizen in 1944.
[Note: This obituary was provided by Professor Dan Rich.]
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2009 Dates of Finance/Department Meetings
Department/Executive Committee Meetings - Tuesdays - 1:30 PM - Room 9341 Chemistry
TBA
Finance Committee Meetings - Tuesdays - 1:30 PM - Room 1130
TBA
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SEMINARS
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Thursday, July 2nd, 2009 - Herb Seminar, 10:00 a.m., 5310 Chamberlin. Dr. Neil Zimmerman, National Institute of Standards and Technology. “Quantum Dots and Quantum Information”
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Tuesday, September 8th, 2009 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Steven Baldelli, University of Houston.
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Thursday, September 10th, 2009 - Analytical Chemistry Seminar, 12:15 p.m., Room 1315 Chemistry Building. Robert T. Kennedy, University of Michigan.
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Thursday, September 17th, 2009 - Analytical Chemistry Seminar, 12:15 p.m., Room 1315 Chemistry Building. Jarrod Marto, Harvard University.
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Thursday, September 17th, 2009 - Sponsored by the Science, Religion, and Ethics Program of the Wisconsin Initiative for Science Literacy, 7:30 p.m., Room 1315 Chemistry Building. UW Philosophy Professor Steven Nadler entitled “Science and Religion in Jewish Thought, or, What Maimonides Really Meant” Steven Nadler is the William H. Hay II Professor, and Max & Frieda Weinstein/Bascom Professor of Jewish Studies and chair of the UW-Madison Philosophy Department.
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Tuesday, September 22nd, 2009 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Paul Hergenrother, University of Illinois-Urbana.
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Wednesday, September 23rd, 2009 - Meloche Lecture, 3:30 p.m., Room 1315 Chemistry Building. Professor Harry B. Gray, California Technology Institute.
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Thursday, September 24th, 2009 - Meloche Lecture, 3:30 p.m., Room 1315 Chemistry Building. Professor Harry B. Gray, California Technology Institute.
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Thursday, September 24th, 2009 - Analytical Chemistry Seminar, 12:15 p.m., Room 1315 Chemistry Building. Caniel Chiu, University of Washington.
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Friday, September 25th, 2009 - Shain Colloquium, 3:30 p.m., Room 1315 Chemistry Building. Professor Harry B. Gray, California Technology Institute.
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Tuesday, September 29th, 2009 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Ron Elber, The University of Texas at Austin.
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Wednesday, October 10th, 2009 - Inorganic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Professor Slavi Sevov, Notre Dame.
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Monday, October 12th, 2009 - Theoretical Chemistry Joseph O. Hirschfelder Lecture, 2:00 p.m., Room 1315 Chemistry Building. Professor Peter Wolynes, University of California, San Diego.
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Tuesday, October 13th, 2009 - Theoretical Chemistry Joseph O. Hirschfelder Lecture, 11:00 a.m., Room 1315 Chemistry Building. Professor Peter Wolynes, University of California, San Diego.
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Wednesday, October 14th, 2009 - Theoretical Chemistry Joseph O. Hirschfelder Lecture, 2:00 p.m., Room 1315 Chemistry Building. Professor Peter Wolynes, University of California, San Diego.
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Tuesday, October 20th, 2009 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Ben King, University of Nevada, Reno.
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Tuesday, October 20th, 2009 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Ruth Signorell, The University of British Columbia.
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Wednesday, October 21st, 2009 - Inorganic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Professor Karen Goldberg, University of Washington.
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Thursday, October 22nd, 2009 - Analytical Chemistry Seminar, 12:15 p.m., Room 1315 Chemistry Building. Gail Fanucci.
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Tuesday, October 27th, 2009 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Tianquan Lian, Emory University.
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Thursday, October 29th, 2009 - Analytical Chemistry Seminar, 12:15 p.m., Room 1315 Chemistry Building. Heather Dasaire, University of Kansas-Lawrence.
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Thursday, October 29th, 2009 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Albert Padwa, Emory.
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Tuesday, November 3rd, 2009 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Ben Ocko, Brookhaven National Lab.
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Thursday, November 5th, 2009 - Analytical Chemistry Seminar, 12:15 p.m., Room 1315 Chemistry Building. Arne Gericke, Kent State University.
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Tuesday, November 17th, 2009 - McElvain Seminar in Physical Chemistry, 11:00 a.m., Room 1315 Chemistry Building. Professor Marsha Lester, University of Pennsylvania.
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Tuesday, November 24th, 2009 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Patricia L. Clark, University of Notre Dame.
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Tuesday, January 19th, 2010 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor William Schneider, University of Notre Dame.
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Wednesday, January 20th, 2010 - Inorganic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Professor Keith Fagnou, University of Ottawa.
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Tuesday, January 26th, 2010 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Jin Quan Yu, Scripps.
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Tuesday, January 26th, 2010 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Dr. John Orlando, National Center for Atmospheric Research.
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Tuesday, February 2nd, 2010 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building.
Professor Robert Waymouth, Stanford University.
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Tuesday, February 2nd, 2010 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Angel E. Garcia, Rensselaer Polytechnic Institute.
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Thursday, February 4th, 2010 - Analytical Chemistry Seminar, 12:15 p.m., Room 1315 Chemistry Building. Greg Huey, Georgia Tech.
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Tuesday, February 9th, 2010 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building.
Professor Stephen Craig, Duke University.
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Tuesday, February 9th, 2010 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Christiane Alba-Simionesco, Leon Brillouin.
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Thursday, February 18th, 2010 - Ferry Lecture, 12:15 p.m., Room 1315 Chemistry Building. Frank Bates, University of Minnesota.
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Tuesday, February 23rd, 2010 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Horia Metiu, University of California Santa Barbara.
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Tuesday, March 2nd, 2010 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building.
Professor Scott Denmark, University of Illinois-Urbana .
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Tuesday, March 2nd, 2010 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor John Straub, Boston University.
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Tuesday, March 9th, 2010 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building.
Professor Martin Burke, University of Illinois-Urbana.
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Tuesday, March 9th, 2010 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Samuel T. Hess, University of Maine.
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Tuesday, March 16th, 2010 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building.
Professor Steve Buchwald, MIT.
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Tuesday, April 6th, 2010 - McElvain Seminar in Physical Chemistry, 11:00 a.m., Room 1315 Chemistry Building. Professor George Schatz, Northwestern University. “Modeling Self-Assembly of Nanomaterials.”
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Tuesday, April 13th, 2010 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Niels H. Damrauer, University of Colorado.
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Tuesday, April 20th, 2010 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building.
Professor Giovanna Ghirlanda, Arizona State.
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Tuesday, April 20th, 2010 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Joan-Emma Shea, University of California, Santa Barbara.
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Tuesday, April 27th, 2010 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Roberto De Guzman, The University of Kansas.
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Tuesday, May 4th, 2010 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Millard Alexander, University of Maryland.
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Thursday, May 5th, 2010 - Analytical Chemistry Seminar, 12:15 p.m., Room 1315 Chemistry Building. Peter Chen, Spelman College.
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RECENT PUBLICATIONS
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Automated 2D IR spectrometer mitigates the influence of high optical densities.
Xiong, W; Strasfeld, DB; Shim, SH; Zanni, MT*.
VIBRATIONAL SPECTROSCOPY 50 (1): 136-142 Sp. Iss. SI MAY 26 2009.
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A new cavity based absorption instrument for detection of water isotopologues in the upper troposphere and lower stratosphere.
Sayres, DS; Moyer, EJ; Hanisco, TF; Clair, JM; Keutsch, FN*; O'Brien, A; Allen, NT; Lapson, L; Demusz, JN; Rivero, M; Martin, T; Greenberg, M; Tuozzolo, C; Engel, GS; Kroll, JH; Paul, JB; Anderson, JG.
REVIEW OF SCIENTIFIC INSTRUMENTS 80 (4): Art. No. 044102 APR 2009.
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Microfluidic-assisted analysis of replicating DNA molecules.
Sidorova, JM; Li, NZ; Schwartz, DC*; Folch, A; Monnat, RJ.
NATURE PROTOCOLS 4 (6): 849-861 2009.
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Nature of Amide Carbonyl-Carbonyl Interactions in Proteins.
Choudhary, A; Gandla, D; Krow, GR; Raines, RT*.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131 (21): 7244-+ JUN 3 2009.
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General Synthetic Route to Cell-Permeable Block Copolymers via ROMP.
Kolonko, EM; Pontrello, JK; Mangold, SL; Kiessling, LL*.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131 (21): 7327-7333 JUN 3 2009.
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Synthesis and characterization of three new thermally stable N-heterocyclic germylenes.
Tomasik, AC; Hill, NJ*; West, R*.
JOURNAL OF ORGANOMETALLIC CHEMISTRY 694 (13): 2122-2125 JUN 1 2009.
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Toward Defining the Phosphoproteome of Xenopus laevis Embryos.
McGivern, JV; Swaney, DL; Coon, JJ*; Sheets, MD.
DEVELOPMENTAL DYNAMICS 238 (6): 1433-1443 JUN 2009.
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Association of Helical beta-Peptides and their Aggregation Behavior from the Potential of Mean Force in Explicit Solvent.
Miller, CA; Gellman, SH*; Abbott, NL; de Pablo, JJ.
BIOPHYSICAL JOURNAL 96 (11): 4349-4362 JUN 3 2009.
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Glyoxal uptake on ammonium sulphate seed aerosol: reaction products and reversibility of uptake under dark and irradiated conditions.
Galloway, MM; Chhabra, PS; Chan, AWH; Surratt, JD; Flagan, RC; Seinfeld, JH; Keutsch, FN*.
ATMOSPHERIC CHEMISTRY AND PHYSICS 9 (10): 3331-3345 2009.
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Vibrational Line Shapes, Spectral Diffusion, and Hydrogen Bonding in Liquid Water.
Skinner, JL*; Auer, BM; Lin, YS.
ADVANCES IN CHEMICAL PHYSICS, VOL 142 142: 59-103 2009.
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New Advances in Mid-ir Pulse Shaping and its Application to 2d Ir Spectroscopy and Ground-state Coherent Control.
Strasfeld, DB; Shim, SH; Zanni, MT*.
ADVANCES IN CHEMICAL PHYSICS, VOL 141 141: 1-28 2009.
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Cumulants, Extensivity, and the Connected Formulation of the Contracted Schrodinger Equation.
Herbert, JM; Harriman, JE*.
REDUCED-DENSITY-MATRIX MECHANICS - WITH APPLICATION TO MANY-ELECTRON ATOMS AND MOLECULES 134: 261-292 2007.
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Controlling Oligonucleotide Surface Density in Light-Directed DNA Array Fabrication.
Chen, S; Phillips, MF; Cerrina, F; Smith, LM*.
LANGMUIR 25 (11): 6570-6575 JUN 2 2009.
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A New Probabilistic Database Search Algorithm for ETD Spectra.
Sadygov, RG; Good, DM; Swaney, DL; Coon, JJ*.
JOURNAL OF PROTEOME RESEARCH 8 (6): 3198-3205 JUN 2009.
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Chemical Modification of Reactive Multilayered Films Fabricated from Poly(2-alkenyl azlactone)s: Design of Surfaces that Prevent or Promote Mammalian Cell Adhesion and Bacterial Biofilm Growth.
Buck, ME; Breitbach, AS; Belgrade, SK; Blackwell, HE*; Lynn, DM*.
BIOMACROMOLECULES 10 (6): 1564-1574 JUN 2009.
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Silencing an Inhibitor Unleashes a Cytotoxic Enzyme.
Dickson, KA; Raines, RT*.
BIOCHEMISTRY 48 (23): 5051-5053 JUN 16 2009.
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Copyright © 2009 Thomson ISI
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