Chemistry Newsletter - 07/30/2007

 


University of Wisconsin-Madison

Department of Chemistry Newsletter



XXXI - No. 25 July 30th, 2007

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Helen Blackwell named one of Popular Science Magazine’s “Brilliant 10”

We are pleased to announce that Helen Blackwell has been named by Popular Science Magazine as one of their “PopSci's Brilliant 10", a group of ten young scientists cited for doing work that's pushing their field to the next level. Helen will be interviewed and profiled in an upcoming issue of the magazine. Congratulations, Helen!

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Samira Musah Wins a National Science Foundation Graduate Research Fellowship

Samira Musah, a graduate student in Laura Kiessling’s group, has won a National Science Foundation Graduate Research Fellowship. This nationally competitive award is made to outstanding graduate students who can contribute significantly to research, teaching, and innovations in science and engineering. The award provides three years of funding. Congratulations Samira!!

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Department and Finance Committee Meeting Schedule

Department/Executive Committee Meetings - Tuesdays - 1:30 PM - Room 9341 Chemistry

TBA

Finance Committee Meetings - Tuesdays - 1:30 PM - Room 1130

TBA

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SEMINARS

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Monday, August 6th, 2007 - Theoretical Chemistry Institute Seminar, 11:00 a.m., Room 8335, Chemistry Building. Professor Christian Ochsenfeld, Theoretische Chemie, Universität Tübingen, Germany. “Intermolecular Interactions in Large Molecular Systems -- A Challenge for Quantum Chemistry”

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Tuesday, September 4th, 2007 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Anne B. McCoy, The Ohio State University.

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Tuesday, September 4th, 2007 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Prof. Lutz Ackermann, University of Goettingen, Germany

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Wednesday, September 5th, 2007 - Inorganic Seminar, 3:30 p.m., Room 1315 Chemistry Building. Heinrich lang, Technical University of Chemmitz.

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Thursday, September 6th, 2007 - Analytical Seminar - Roger Carlson Award, 12:15 p.m., Room 1315 Chemistry Building. Mark Rickard, Wright Research Group.

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Thursday, September 6th, 2007 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Lauren Boyle (Burke Group).

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Thursday, September 6th, 2007 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Prof. Zhangjie Shi, Peking University.

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Tuesday, September 7th, 2007 - Special Physical Chemistry Seminar, 1:20 p.m., Room 1315 Chemistry Building. Dr. Zahra Fakhraii, University of Waterloo, Ontario, Canada.

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Friday, September 10th, 2007 - Theoretical Chemistry Institute Seminar, 3:30 p.m., Room 8335, Chemistry Building. Professor Feliu Maseras, ICIQ. “Computational Studies on the Mechanism of Transition Metal-Catalyzed C-C Bond Formation Processes”

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Tuesday, September 11th, 2007 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Sarah, L. Keller, University of Washington. “Seeing Spots: Liquid Domains in Lipid Membranes”

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Thursday, September 13th, 2007 - Analytical Seminar, 12:15 p.m., Room 1315 Chemistry Building. Professor Terry Gustafson of Ohio State University.

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Thursday, September 13th, 2007 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Charles Allen (Yoon Group).

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Thursday, September 13th, 2007 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Prof. Olafs Daugulis, University of Houston

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Tuesday, September 18th, 2007 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Prof. Jef De Brabander, University of Texas Medical Center

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Wednesday, September 19th, 2007 - Inorganic Seminar, 3:30 p.m., Room 1315 Chemistry Building. David Eide, UW-Madison, Nutri Sci.

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Thursday, September 20th, 2007 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Margaret Wong (Kiessling Group).

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Wednesday, September 24th, 2007 - Inorganic Seminar, 3:30 p.m., Room 1315 Chemistry Building. James Penner-Hahn, University of Michigan.

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Tuesday, September 25th, 2007 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Leslie H. Allen, University of Illinois at Urbana. “Studies of Materials Confined to Nanometer Dimensions at High Heating and Cooling Rates Using Nanocalorimetry”

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Tuesday, September 25th, 2007 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Prof. Jeffrey Hartgerink, Rice University

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Wednesday, September 26th, 2007 - Inorganic Seminar, 3:30 p.m., Room 1315 Chemistry Building. Avery Watkins, Graduate Student, Landis Group.

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Thursday, September 27th, 2007 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Nicola Burrmann (McMahon Group).

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Wednesday, October 1st, 2007 - Inorganic Seminar, 3:30 p.m., Room 1315 Chemistry Building. Nattawan Decharin, Graduate Student, Stahl Group.

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Tuesday, October 2nd, 2007 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Philip J. Reid, University of Washington.

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Tuesday, October 2nd, 2007 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Prof. Robert Williams, Colorado State University

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Wednesday, October 3rd, 2007 - Inorganic Seminar, 3:30 p.m., Room 1315 Chemistry Building. Richard Finke, Colorado State.

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Thursday, October 4th, 2007 - Analytical Seminar, 12:15 p.m., Room 1315 Chemistry Building. Dr. Katheryn Resing of the University of Colorado at Boulder.

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Thursday, October 4th, 2007 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Dr. Gui-Bai Liang, Merck

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Tuesday, October 9th, 2007 - Physical Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Professor Erin D. Sheets, Pennsylvania State University.

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Tuesday, October 9th, 2007 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Prof. Jeffrey Kelly, Scripps Research Institute

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Wednesday, October 10th, 2007 - Inorganic Seminar, 3:30 p.m., Room 1315 Chemistry Building.Brian Bennett, Medical College of Wisconsin, National Biomedical EPR Center. “Mechanistic Insights into the Dizinc Leucine Aminopeptidase from Vibrio”

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Thursday, October 11th, 2007 - Analytical Seminar, 12:15 p.m., Room 1315 Chemistry Building.Dr. Roman Zubarev of Uppsala University, Sweden.

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Thursday, October 11th, 2007 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Ram Neupane (Landis Group).

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Friday, October 12th, 2007 - Treichel Minisymposium, 10:00 a.m., Room 1315 Chemistry Building. More Information Coming.

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Tuesday, October 16th, 2007 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Prof. Justin Gallivan, Emory University

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Thursday, October 18th, 2007 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Christopher Shaffer (McMahon Group).

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Tuesday, October 23rd, 2007 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Prof. Kent Kirshenbaum, New York University

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Thursday, October 25th, 2007 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Nickeisha Stephenson (Stahl/Gellman Group).

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Tuesday, October 30th, 2007 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Prof. Mo Movassaghi, Massachusetts Institute of Technology

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Thursday, November 1st, 2007 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Roberto Risi (Burke Group).

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Thursday, November 8th, 2007 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Jessica Strasser (Burke Group).

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Tuesday, November 13th, 2007 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Prof. Ross Weatherman, Purdue University

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Thursday, November 15th, 2007 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Rhiannon Carter (Mahanthappa Group).

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Thursday, November 29th, 2007 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Sayani Chattopadhyay (Raines Group).

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Tuesday, December 4th, 2007 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Prof. Helen Blackwell, University of Wisconsin-Madison

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Thursday, December 6th, 2007 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Michael Giuliano (Gellman Group).

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Thursday, December 13th, 2007 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Amanda Musch (Berry Group).

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Thursday, January 24th, 2008 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Christine McInnis (Blackwell Group).

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Tuesday, January 29th, 2008 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Prof. Cynthia Burrows, University of Utah

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Thursday, January 31st, 2008 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Michael Ischay (Yoon Group).

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Thursday, February 7th, 2008 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Corinne Lipscomb (Weibel Group).

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Monday, February 11th and Tuesday, February 12th, 2008 - Organic Chemistry Merck Lecture Series, 3:30 p.m., Room 1315 Chemistry Building. Prof. Timothy Swager, Massachusetts Institute of Technology,

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Thursday, February 14th, 2008 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Shane Mangold (Kiessling Group).

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Thursday, February 21st, 2008 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Joel Broussard (Stahl Group).

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Tuesday, February 26th, 2008 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Prof. Tom Rovis, University of Colorado

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Thursday, February 28th, 2008 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Lani MacArtney (Stahl Group).

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Tuesday, March 4th, 2008 - Organic Chemistry Seminar, 3:30 p.m., Room 1315 Chemistry Building. Prof. Stephen Craig, Duke University

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Thursday, March 6th, 2008 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Mary Anzovino (Yoon Group).

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Thursday, March 13th, 2008 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Jay Steinkruger (Gellman Group).

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Thursday, March 27th, 2008 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. David Moody (Mahanthappa Group).

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Thursday, April 3rd, 2008 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Emily Blamer (Gellman/Stahl Group).

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Tuesday, April 15th and Wednesday April 16 th, 2008 - Organic Chemistry Hirschmann Lecture Series, 3:30 p.m., Room 1315 Chemistry Building. Prof. Carolyn Bertozzi, UC-Berkeley

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Thursday, April 17th, 2008 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Brooke Richardson (Gellman Group).

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Thursday, April 24th, 2008 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Reto Frei (Blackwell Group.)

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Thursday, May 1st, 2008 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Alexander Khrizman (Yoon Group).

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Thursday, May 8th, 2008 - Organic Chemistry Seminar, 11:00 a.m., Room 1315 Chemistry Building. Aimon Tongpenyai (Kissling Group).

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Professional Grant Proposal Writing Workshop

The Grant Institute's Grants 101: Professional Grant Proposal Writing Workshop will be held in Ann Arbor, Michigan, August 15 - 17, 2007. Interested development professionals, researchers, faculty, and graduate students should register as soon as possible, as demand means that seats will fill up quickly. All participants will receive certification in professional grant writing from the Institute. For more information call (888) 824 - 4424 or visit the Grant Institute at: http://www.thegrantinstitute.com. The Grant Institute Grants 101: Professional Grant Proposal Writing Workshop will be held in Ann Arbor, Michigan on August 15 - 17, 2007, 8:00 AM - 5:00 PM .The Grant Institute's Grants 101 course is an intensive and detailed introduction to the process, structure, and skill of professional proposal writing. This course is characterized by its ability to act as a thorough overview, introduction, and refresher at the same time. In this course, participants will learn the entire proposal writing process and complete the course with a solid understanding of not only the ideal proposal structure, but a holistic understanding of the essential factors, which determine whether or not a program gets funded. Through the completion of interactive exercises and activities, participants will complement expert lectures by putting proven techniques into practice. This course is designed for both the beginner looking for a thorough introduction and the intermediate looking for a refresher course that will strengthen their grant acquisition skills. This class, simply put, is designed to get results by creating professional grant proposal writers. Participants will become competent program planning and proposal writing professionals after successful completion of the Grants 101 course. In three active and informative days, students will be exposed to the art of successful grant writing practices, and led on a journey that ends with a masterful grant proposal. Grants 101 consists of three (3) courses that will be completed during the three-day workshop.

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Deepening Your Mastery of College Education

Several Fall and Spring 2007-08 courses about higher education teaching may be of interest, especially to doctoral students and perhaps faculty members. Seminar sessions are scheduled on Tuesday evenings in room 218 Educational Sciences, 1025 W. Johnson. Access and flexibility is enhanced by use of distance education audio and computer conferencing through Learn@UW. The Fall courses are ELPA 305-746 Adult Learner: Implication for Curriculum and Instruction; and ELPA 305-730 Program Development in Continuing Education. The Spring courses are ELPA 305-742 Facilitating Learning for Adults; and ELPA 305-826 Evaluation for Administrative Decision Making. Each course emphasizes applications to the student's content area. The instructor is Alan B. Knox, founding member and early chair of the UW Madison Teaching Academy, whose graduate teaching and research has long focused on helping adults learn. http://www.education.wisc.edu/elpa/people/faculty/knox.html. The four course syllabi are posted on the departmental website: http://www.education.wisc.edu/elpa/ click on syllabi, semester, and course number. One or more of these and other courses related to higher education teaching can be taken as electives or as a minor. For additional information contact: Alan B. Knox at: knox@education.wisc.edu, phone: 263-2937; or Shari Smith, ssmith@education.%20wisc.edu, phone: 263-2701.

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Recent Publications

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Conformational changes of glucose/galactose-binding protein illuminated by open, unliganded, and ultra-high-resolution ligand-bound structures.

Borrok, MJ; Kiessling, LL*; Forest, KT.

PROTEIN SCIENCE 16 (6): 1032-1041 JUN 2007.

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Refinements in the description of excited VRT states of the water dimer.

Harker, HA; Keutsch, FN*; Leforestier, C; Scribano, Y; Han, JX; Saykally, RJ.

MOLECULAR PHYSICS 105 (5-7): 513-527 MAR-APR 2007.

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Selectivity in the ruthenium-catalyzed alder ene reactions of di- and triynes.

Cho, EJ; Lee, D*.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129 (21): 6692-+ MAY 30 2007.

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Heterogeneous helix-bundle quaternary structure formed by alpha/beta-peptide foldamers and alpha-peptides.

Price, JL; Home, WS; Gellman, SH*.

BIOPOLYMERS 88 (4): 568-568 Sp. Iss. SI 2007.

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Lyotropic liquid crystals from designed helical beta peptides.

Pomerantz, WC; Pizzey, C; Yuwono, V; Paramanov, S; Hartgerink, J; Gellman, SH*; Abbott, NL.

BIOPOLYMERS 88 (4): 570-570 Sp. Iss. SI 2007.

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Modulating collagen triple helix stability with 4-chloro-, 4-fluoro-, and 4-methylprolines.

Shoulders, MD; Raines, RT*.

BIOPOLYMERS 88 (4): 593-593 Sp. Iss. SI 2007.

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Helical secondary structures in alpha/beta-peptides by crystallographic characterization.

Choi, SH; Guzei, IA*; Gellman, SH*.

BIOPOLYMERS 88 (4): 607-607 Sp. Iss. SI 2007.

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Structure and dynamics of conjugated polymers in liquid crystalline solvents.

Barbara, PF; Chang, WS; Link, S; Scholes, GD; Yethiraj, A*.

ANNUAL REVIEW OF PHYSICAL CHEMISTRY 58: 565-584 2007.

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Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics.

Khidekel, N; Ficarro, SB; Clark, PM; Bryan, MC; Swaney, DL; Rexach, JE; Sun, YE; Coon, JJ*; Peters, EC; Hsieh-Wilson, LC.

NATURE CHEMICAL BIOLOGY 3 (6): 339-348 JUN 2007.

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Solvent control of charge localization in 11-bond bridged dinitroaromatic radical anions.

Nelsen, SF*; Weaver, MN; Telo, JP.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 129 (22): 7036-7043 JUN 6 2007.

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Exploration of backbone space in foldamers containing alpha- and beta-amino acid residues: Developing protease-resistant oligomers that bind tightly to the BH3-recognition cleft of Bcl-x(L).

Sadowsky, JD; Murray, JK; Tomita, Y; Gellman, SH*.

CHEMBIOCHEM 8 (8): 903-916 MAY 25 2007.

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HeLa cell entry by guanidinium-rich beta-peptides: Importance of specific cation-cell surface interactions.

Potocky, TB; Silvius, J; Menon, AK; Gellman, SH*.

CHEMBIOCHEM 8 (8): 917-926 MAY 25 2007.

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Copyright © 2007 Thomson ISI

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EMPLOYMENT OPPORTUNITIES

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On behalf of Bristol-Myers Squibb and our strategic partner Biocon Limited, we want to inform you about the ongoing recruitment of talented scientists (M.S. and Ph.D.) for research positions at Biocon's state-of-the-art facilities in Bangalore, India. We are requesting that you post the enclosed flyer for viewing by interested students and researchers, in advance of our upcoming ads in high profile journals (i.e., C&E News, Science, Nature). Bristol-Myers Squibb (BMS) has recently announced a strategic alliance with Biocon Limited as a next step in the global expansion of BMS's drug discovery and early drug development activities. Biocon's subsidiary, Syngene International, is working with BMS to build and establish a new research facility in Bangalore that can ultimately house more than 400 researchers. Scientists trained in the fields of chemistry, biology, drug metabolism, pharmaceutical development, and veterinary sciences are being recruited to join this effort to establish a highly integrated R&D team in one of India's fastest developing cities. A subset of your students and fellow researchers may have professional or personal reasons for exploring these job opportunities in India. In particular, this letter is meant to inform you about attractive ex-U.S. job opportunities for chemists (M.S. and Ph.D.) with a company that is a preferred partner of BMS. As such, Biocon is seeking bright, energetic, and talented individuals with excellent training across the spectrum of chemistry: organic, medicinal, process, combinatorial, and analytical chemistry. Please take a minute to examine the enclosed materials and post them in a common area for viewing by prospective candidates for their consideration. Syngene, a Biocon company offers competitive compensation and benefits including stock options. Apply at: http://www.biocon.com.

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Pacific Northwest National Laboratory (PNNL), Job ID: 113525. Directorate: Fundamental Science Directorate. Division: Chemical and Materials Sciences Division. Group: Molecular Interactions & Transformations. This position involves fundamental research in synthetic and mechanistic organometallic chemistry, aimed at the design and discovery of new molecular catalysts. Candidates must have experience in synthetic and mechanistic organometallic/inorganic chemistry and handling air-sensitive materials is required. Excellent oral and written communications skills are mandatory. Experience with a range of spectroscopic techniques, including electrochemistry, is highly desirable. Experience in synthetic and mechanistic organometallic/inorganic chemistry and handling air-sensitive materials is required. Excellent oral and written communications skills are mandatory. Experience with a range of spectroscopic techniques, including electrochemistry, is highly desirable. Candidates must have received a PhD in organometallic, inorganic or organic chemistry within the past five years from an accredited college or university. To Apply: Please go to: http://jobs.pnl.gov/ and apply to Job ID 113525.

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The Department of Chemistry at the University of Pennsylvania has an opening for an Associate NMR Facility Manager/Postdoc. The facility consists of ten spectrometers ranging from 200Mhz to 600 MHz. Experience with Bruker instruments a plus but not required. Programming skills in C, C++, Perl, CGI scripting and developing web based tools a strong asset. The appointment is for one year renewable up to three years at the end of which promotion to permanent status is a possibility. Extremely qualified persons will be considered for a permanent position immediately. Education requirements: recent Ph.D. or BS/MS with 2-5 years experience in a NMR related position. The University of Pennsylvania is an Equal Opportunity Employer. Permanent U.S. residency preferred but not required. Inquiries and resumes may emailed to: Dr. George Furst, Assoc. Director Technical Facilities, Department of Chemistry, University of Pennsylvania, Philadelphia, Pa 19104-6323, e-mail: furst@sas.upenn.edu.

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Position as Research Fellow (stipendiat) is available at the Department of Chemistry, http://www.kjemi.uio.no/. A position as PhD. student / research fellow (stipendiat) will be available at the Department of Chemistry, University of Oslo. The position is advertised primarily in biomolecular and biological NMR-spectroscopy and alternatively in synthetic organic chemistry. The research fellow will be a part of the Synthesis and Structure research group at the section for Life Sciences, Department of Chemistry. The position is available for 4 years. The successful candidate will have to participate in the teaching responsibilities of the Department of Chemistry, with a nominal 25 % teaching load. For more details, please see the following link: http://www.admin.uio.no/opa/ledige-stillinger/2007/vit/researchfellowChemistry-07-6755.html.

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FACULTY POSITIONS/TEMPORARY FACULTY/ACADEMIC POSITIONS

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Stanford University, Department of Chemistry. Three faculty positions are available. One at any level, in the general area of Synthetic Chemistry. One at the junior level in the general area of Synthetic Chemistry. One at the junior level in the general area of Biological Chemistry. Appointment will commence on or after September 1, 2008. Completed applications must be received by October 1, 2007. To ensure full consideration of your application, please ensure that all letters of reference arrive by this deadline. Applicants must be strongly motivated toward creative research and committed to teaching at the undergraduate and graduate levels. Applications must include the following materials: Current curriculum vitae & list of publications; Brief statement of research interests; Three letters of reference (for junior level candidates only) sent directly to the search committee, on your behalf. Send applications and supporting materials to the appropriate committee below, as follows: 2007-08 Synthetic Chemistry Search Committee OR 2007-08 Biological Chemistry Search Committee, Department of Chemistry, Stanford University, Stanford, CA 94305-5080.

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Chair, Department of Biochemistry and Cell Biology. Stony Brook University’s Department of Biochemistry and Cell Biology is an internationally recognized interdisciplinary research and education department with an outstanding record of research achievement. Currently, the Department has 20 tenured/tenure-track faculty having research interests covering the broad areas of biochemical and cell biological sciences. The Department also has close relationships with faculty at Brookhaven National Laboratory and Cold Spring Harbor Laboratory. We are seeking an outstanding scientific leader to direct the future growth of the Department. The candidate must also be committed to the Department's undergraduate, graduate and medical education programs. Required: Ph.D. or equivalent degree, the academic rank of Professor and a vigorous research program that is recognized at both the national and international level, as judged by extramural funding, scholarly publications and invited presentations. The successful candidate must have an eagerness to promote multidisciplinary interactions and a demonstrated record of success in graduate student and/or postdoctoral training. Substantial start-up package for the Chair with resources for the expansion of the Department in both research and teaching will be provided through the College of Arts & Sciences and the School of Medicine. The review of applications will begin September 1, 2007 and will continue until the position is filled. For more information, please visit: http://www.sunysb.edu/biochem/. Interested individuals can apply online at www.stonybrook.edu/cjo (Referene number: F-4196-07-07) or forward a curriculum vitae to: Biochemistry and Cell Biology Chair Search Committee, c/o Carol Galdi, Department of Biochemistry and Cell Biology, Stony Brook University, SUNY, 450 Life Sciences Building, Stony Brook, New York 11794-5215.

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POSTDOCTORAL POSITIONS AND/OR JOBS

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Washington University. Post-doctoral Fellow Positions Available. Using mouse models to understand normal growth control and tumor formation in the mammalian brain. The development of the mammalian brain is a highly regulated process involving both cell-autonomous and non-cell-autonomous decisions that determine cell fate, proliferation, migration and death. The genes that govern these critical decisions are often mutated in human cancers, and their de-regulated function in the central nervous system (CNS) leads to the development of brain tumors. Our laboratory is interested in understanding the key signals that control normal neural stem cell (NSC) and glial cell growth and differentiation in vitro and in vivo. To this end, we study the genes mutated in the two cancer predisposition syndromes, neurofibromatosis 1 (NF1) and neurofibromatosis 2 (NF2), in which affected individuals develop brain tumors.We have generated numerous genetically-engineered mouse models to explore the relationship between developmental neurobiology (normal growth regulation in the brain) and neuro-oncology (brain tumor formation). Our studies of the NF1and NF2 tumor suppressor genes have elucidated several important growth regulatory pathways that dictate cell growth and differentiation in astrocytes (glia), neurons, and neural stem cells.We are currently studying how regulation of Ras signaling, mammalian target of rapamycin (mTOR) activity, and intracellularcyclic AMP generation controls cell proliferation, cell death, and differentiation in each of these cell types in the brain both in vitro and in vivo. Similar to the developing brain, neoplastic cells receive cues from their local microenvironment that regulate cell proliferation.Using Nf1 mouse brain tumor models, we have identified both cellular and biochemical signals that emanate from the tumor microenvironment (stroma) to control tumor growth.Current studies are focused on determining how brain immune system cells (microglia) promote tumor cell proliferation as well as on identifying additional stromal patterning cues that dictate where and when tumors form in the brain.Recent studies suggest that brain tumors may arise from cells with stem cell properties (cancer stem cells).To understand the relationship between normal neural stem cell function and tumorigenesis in the brain, we have developed several mouse models in which select tumor suppressor genes are inactivated in neuroglial progenitors.We are actively using these in vivo models in combination with in vitro systems to define the role of these genes and their downstream signaling pathways in governing cell fate decisions in the CNS. Interested candidates should contact: David H. Gutmann, MD-PhD at the Washington University School of Medicine, e-mail: gutmannd@neuro.wustl.edu.

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Please submit all newsletter information or address changes to: goldade@chem.wisc.edu or 262-0293. Thank You.

DETAILS ARE AVAILABLE IN ROOM 1146.

NEXT NEWSLETTER IS ON AUGUST 13th, 2007.