Chemistry Newsletter - 07/30/2001

 

University of Wisconsin-Madison

Department of Chemistry Newsletter


XXV No. 26 July 30th, 2001

Department and Finance Committee Meeting Schedule

Department Meetings --- Tuesdays - 1:30 PM - Room 8335 Chemistry

*****No Meetings Until September*****

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SEMINARS

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Friday, August 24, 2001 - Inorganic and Organic Chemistry Seminar, 2:30 p.m., Room: TBA, Chemistry Building. Professor Jan-E. Bäckvall, Arrhenius Laboratory, Stockholm University. "Transitional Metal Hydrides as Active Intermediates in Hydrogen Transfer Reactions"

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For Industrial Positions, see the Chemistry Career Services Newsletter at:

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http://www.chem.wisc.edu/areas/careers/7news.html

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RECENT PUBLICATIONS

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Klink TA; Vicentini AM; Hofsteenge J; Raines RT.

High-level soluble production and characterization of porcine ribonuclease inhibitor.

PROTEIN EXPRESSION AND PURIFICATION 2001, Vol 22, Iss 2, pp 174-179.

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Porembski M; Weisshaar JC.

Kinetics and mechanism of the reactions of ground-state Y (4d(1)5s(2), D-2) with ethylene and propylene: Experiment and theory.

JOURNAL OF PHYSICAL CHEMISTRY A 2001, Vol 105, Iss 27, pp 6655-6667.

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Kalyuzhnyi YV; Lin CT; Stell G; Yethiraj A.

Structural and thermodynamic properties of a freely-jointed Yukawa hard-sphere chain fluid.

JOURNAL OF MOLECULAR LIQUIDS 2001, Vol 92, Iss 1-2, pp 85-96.

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Holbrook JA; Tsodikov OV; Saecker RM; Record MT.

Specific and non-specific interactions of integration host factor with DNA: Thermodynamic evidence for disruption of multiple IHF surface salt-bridges coupled to DNA binding.

JOURNAL OF MOLECULAR BIOLOGY 2001, Vol 310, Iss 2, pp 379-401.

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Condren SM; Lisensky GC; Ellis AB; Nordell KJ; Kuech TF; Stockman SA.

LEDs: New lamps for old and a paradigm for ongoing curriculum modernization.

JOURNAL OF CHEMICAL EDUCATION 2001, Vol 78, Iss 8, pp 1033-1040.

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Widstrand CG; Nordell KJ; Ellis AB.

Designing and reporting experiments in chemistry classes using examples from materials science: Illustrations of the process and communication of scientific research.

JOURNAL OF CHEMICAL EDUCATION 2001, Vol 78, Iss 8, pp 1044-1046.

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Clark RW; Guzei IA; Ivanov SA; Burke SD; Lambert WT.

The lack of C2 molecular symmetry in (1R,2R,3S,6S)-3,6-dibenzyloxycyclo-hex-4-ene-1,2-diol.

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS 2001, Vol 57, pp 844-845.

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Lowe TL; Strzelec A; Kiessling LL; Murphy RM.

Structure-function relationships for inhibitors of beta-amyloid toxicity containing the recognition sequence KLVFF.

BIOCHEMISTRY 2001, Vol 40, Iss 26, pp 7882-7889.

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Copyright © 2001 Institute for Scientific Information

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US Army Research Laboratory (WMRD) Research Fellowships for Scientists and Engineers

National Research Council (NRC) Associateship Programs - TJ 2114, National Research Council, 2101 Constitution Avenue NW, Washington, DC 20418, Telephone: 202-334-2760 e-mail to: rap@nas.edu.

American Society for Engineering Education (ASEE) American Society for Engineering Education, 1818 N Street, N.W., Suite 600, Washington, DC 20036-2479, Telephone: (202) 331-3525 e-mail to: projects@asee.org.

Application Process: Applicants must be US Citizens; Applicants are judged based on their proposed research, their education, and the expertise needed to conduct the research. The applicant develops an original research proposal in consultation with the ARL adviser. This proposal is then rated by an external (to both ARL and NRC/ASEE) review panel.

NRC: February Review applications must be postmarked by January 15, June Review applications must be postmarked by April 15, and October Review applications must be postmarked by August 15.

ASEE: Applications are processed throughout year (approximately 6 weeks).

Stipends: The starting stipend for NRC Associates in 2001 is $59,000. Benefits: Funds are also provided for relocation, individual or family heath insurance, and professional travel during tenure. Information/Application Materials: Contact Dr. R.C. Sausa, phone: 410 306-0660; email: sausa@arl.army.mil or Dr. W.R. Anderson, phone: 410 306-0731; email: willie@arl.army.mil for possible research opportunities, and the NRC/ASEE Programs for a detailed brochure and application form. Current NCR/ARL Opportunities: Flame Diagnostics Employing Molecular Beam/Mass Spectromeyrt and Laser Spectroscopy. (76.30.04.B3149) R.C. Sausa; Detailed Modeling of the Chemistry and Physics of Combustion. (76.30.04.B3154) W.R. Anderson; Laser-Based Sensitive Detection of Energetic Materials. (76.30.02.B4148) R.C. Sausa; In Situ Characterization of Novel, Pulsed Laser Deposited Thin Films. (76.30.08.B3183) R.C. Sausa.

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EMPLOYMENT OPPORTUNITIES

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University of Wisconsin-Madison, Chemistry Department. Technical Assistantship: NMR Spectroscopy. The Department is seeking applicants for two technical assistant positions for NMR spectroscopy to begin in September 2001 (fall session). Applicants must have already taken fall or spring semester Chem. 636, and will primarily assist in teaching labs for this course. Other duties are involved with these positions. These positions should be valuable to the individual and his or her research group because of the additional expertise the student will gain in NMR spectroscopic techniques. Please contact the NMR Director, Dr. Charlie Fry, e-mail: fry@chem.wisc.edu or 262-3182 immediately if you are interested.

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Biogen currently has several open positions for chemists at the Scientist and Associate Scientist levels. We are seeking creative and motivated chemists with exceptional potential; we hope to fill these positions before the end of 2001. Please inform your colleagues and students of the opportunities described below. The successful Scientist candidates will be involved in the design, synthesis, purification, and characterization of novel biologically active compounds and serve as members of an interdisciplinary team to identify and optimize novel drug candidates. The position requires a PhD in organic or medicinal chemistry with 0-5 years post-doctoral experience. The candidates should possess a broad knowledge of organic synthesis and related disciplines, especially retrosynthetic analysis, reaction mechanisms, stereochemistry, molecular modeling, and molecular recognition. Familiarity with relevant biological disciplines is a plus (e.g., biochemistry, molecular biology, pharmacology) and of particular value is the ability to integrate insights from these disciplines into the design of new biologically active compounds. The candidates should be accomplished experimentalists in the areas of multi-step synthesis, purification, and characterization of organic compounds. Especially important techniques include column chromatography, HPLC, NMR, MS, and parallel or combinatorial synthesis. Finally, successful candidates will also possess the potential for intellectual leadership, strong communication skills, good problem solving abilities, and an ability to work effectively with a diverse team of co-workers. The successful Associate Scientist candidates will also be involved in the design, synthesis, purification, and characterization of novel biologically active compounds and serve as members of an interdisciplinary team to identify and optimize novel drug candidates. The position requires a BS or MS in chemistry. The candidates should possess a working knowledge of organic synthesis and related disciplines and be proficient experimentalists in the areas of multi-step synthesis, purification, and characterization of organic compounds. Especially important techniques include column chromatography, HPLC, NMR, MS, and parallel or combinatorial synthesis. Finally, successful candidates will also possess strong communication skills, good problem solving abilities, and an ability to work effectively with a diverse team of co-workers. Biogen, winner of the U.S. National Medal of Technology, is a biopharmaceutical company principally engaged in discovering and developing drugs for human healthcare through genetic engineering. Headquartered in Cambridge, MA, the company's revenues are generated from international sales of AVONEX (interferonpla) for treatment of relapsing forms of multiple sclerosis, and from the worldwide sales by licensees of a number of products, including ainterferon and hepatitis 13 vaccines and diagnostic products. Biogen's research and development activities are focused on novel products to treat inflammatory and autoimmune diseases, neurological diseases, cancer, fibrosis and congestive heart failure. The company maintains active clinical research programs in protein therapeutics, small molecules, genomics and gene therapy. For copies of press releases and additional information about Blogen, please consult Biogen's homepage on the world wide web at http://www.biogen.com. Please have interested parties forward their CVs, letters, and questions to: Russell C. Petter, PhD Director of Medicinal Chemistry, Fourteen Cambridge Center, Cambridge, MA 02142, phone: 617-679-3250 or 2000, Fax: 617-679-2616, e-mail: russell_petter@biogen.com.

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Junior faculty position at the Fred Hutchinson Cancer Research Center. The Division of Human Biology at the Fred Hutchinson Cancer Research Center is soliciting applications to fill an open junior faculty position in the areas of genomics and human genetics. Applicants with outstanding accomplishments, particularly in the areas of complex disease-gene mapping, population genetics, large-scale approaches to functional genomics, proteomics, or bioinfolinatics are encouraged to apply. The Human Biology Division fosters interdisciplinary, collaborative research at the interfaces of basic, clinical, and population sciences to further our understanding of human biology, cancer, and other complex human disorders. Additional information about the Division can be found at: http://www.fhcrc.org/science/human_biology/. Candidates should send a curriculum vita, a concise statement of research plans, and three letters of reference to: Human Biology Faculty Search Committee, Fred Hutchinson Cancer Research Center, Division of Human Biology, Mailstop: C3-168, 1100 Fairview Avenue North, P.O. Box 19024, Seattle WA 98109-1024. The application deadline is September 30, 2001.

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FACULTY POSITIONS/TEMPORARY FACULTY/ACADEMIC POSITIONS

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The Department of Chemistry at Kansas State University invites applications for the position of Research Associate to work in the research group directed by Professor Duy Hua. A Ph.D. in Chemistry or a related field is required and previous experience in organic synthesis and methodology development is needed. The research associate will be working in developing new chiral ligands and methodologies for asymmetric catalysis, and synthesizing biologically active compounds. The initial appointment will be for a period of one year, renewed annually consistent with funding and satisfactory performance, with a salary commensurate with experience. Applicants should send a curriculum vitae and three letters of recommendation to: Professor Duy H. Hua, Department of Chemistry, 111 Willard Hall, Kansas State University, Manhattan, KS 66506-3701. Screening of applications will commence August 15, 2001 and continue until position is filled.

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The Department of Chemistry, University at Buffalo, The State University of New York, invites applications for a new tenure track Assistant Professorship with research interests in the area of environmental analytical chemistry, as broadly conceived. The successful candidate must be committed to undergraduate and graduate education, is expected to develop or have a vigorous, funded research program, and shall conduct research in areas that complement, rather than duplicate, existing analytical chemistry research efforts. A list of current faculty and sampling of programs within the Department of Chemistry is available at: http://www.chem.buffalo.edu/. A cover letter, curriculum vitae, brief statement of teaching philosophy and research plans (< 10 pages), and three letters of recommendation should be sent to: Analytical Search Committee Chair Department of Chemistry Natural Sciences Complex University at Buffalo The State University of New York Buffalo, NY 14260-3000. Review of applications will begin on October 1, 2001, and will continue until the position is filled.

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Stanford University Department of Chemistry. Tenure-track faculty appointment in the general area of Inorganic Chemistry or Organic Chemistry. Completed applications must be received by October 15, 2001. Appointment will commence on or after September 1, 2002. Applicants must be strongly motivated toward creative research and committed to teaching at undergraduate and graduate levels. All applications must include the following materials: Current curriculum vitae & list of publications, Brief statement of research interests (three pages or less), Arrange to have three letters of reference sent on your behalf to the chair of the appropriate search committee (see below). Send applications in the general area of Inorganic Chemistry to: Chair, 2001-02 Inorganic Chemistry Search Committee Department of Chemistry Stanford University Stanford, CA 94305-5080. Send applications in the general area of Organic Chemistry to: Chair, 2001-02 Organic Chemistry Search Committee Department of Chemistry Stanford University, Stanford, CA 94305-5080.

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The Department of Chemistry at the Massachusetts Institute of Technology invites applications for tenure-track position in experimental and theoretical Physical Chemistry, Organic Chemistry, and Biological Chemistry for July 2002. The level of appointment is at the rank of Assistant Professor. For Biological Chemistry, applications for appointment at more senior levels are also welcome. This position requires a Ph.D. (or equivalent) and post-doctoral experience is preferred. Outstanding individuals with strong commitment to research and teaching are encouraged to apply by arranging to have a curriculum vitae, a brief description of research plan, and three letters of recommendation sent to: Professor Stephen J. Lippard, Department of Chemistry, 18-399, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139. Application deadline: October 15, 2001.

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The Chemistry Department at Wichita State University seeks candidates for the position of Assistant Professor of Chemistry in the area of physical chemistry to begin in January or August 2002. The individual will teach courses in the undergraduate and graduate programs, including introductory chemistry; establish an externally funded research program; supervise the research activity of undergraduate and graduate students; and will serve on committees as assigned by the department. A Ph.D. degree in Chemistry with postdoctoral experience; research experience in physical chemistry; instructional experience either in the laboratory or classroom; effective writing and interpersonal communication skills; demonstrated ability to work with diverse populations; and a commitment to diversity. Complete application package requires: A letter of application that indicates interest in the position and addresses all of the qualifications for the position; a current resume; evidence of the required degree; a description of future research plans along with estimates of equipment costs; a description of instructional experience either in the laboratory or classroom; a list of three professional references whom we may contact with name and title, address, phone and email addresses. Send the complete application package to: Professor D. Paul Rillema, Department of Chemistry, Wichita State University, Wichita, KS 67260-0051; voice 316-978-3732; e-mail: paul.rillema@wichita.edu. To ensure full consideration, complete applications must be received by October 15, 2001.

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POSTDOCTORAL POSITION AND/OR JOBS

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Postdoctoral Positions Available - Boston University. I am pleased to announce the availability of two or more postdoctoral positions in bioanalytical chemistry (surface biomolecular interactions) within my research group at Boston University. Current projects are focused around the development of novel label-free DNA microarray technologies and SPR/MALDI. Areas of study include: Electric field effects at interfaces, rapid mismatch discrimination by electric field induced denaturation, DNA/drug interactions, kinetics of binding novel platinum anti-tumor drugs with oligonucleotides. http://www.bu.edu/chemistry/faculty/profile/georgiadis.html. Because of the interdisciplinary nature of my research, candidates with interests crossing the traditional boundaries of physical, biological, inorganic, and materials chemistry are encouraged to apply, however, engineering and biophysics students are also welcome. The ideal candidate will have a strong background in one or more of the following areas: General optical techniques and laser spectroscopy; Especially surface plasmon resonance spectroscopy and imaging techniques; Drug/DNA interactions; Characterization of solid/liquid interfaces; Electrochemistry of monolayer films; surface chemistry; immobilization at interfaces; Protein/DNA interactions or protein/surface interactions. Interested candidates should arrange for two letters of reference and send a CV and a brief statement of interests by email (Word, PDF, HTML) or regular mail to: Prof. Rosina Georgiadis, Department of Chemistry, Adjunct Professor, Biomedical Engineering Boston University, 590 Commonwealth Avenue, Boston MA 02215, e-mail: rgeorgia@bu.edu.

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Australian National University. Research School of Chemistry, Inorganic Chemistry, Postdoctoral Fellows (Level A). Applications are invited for postdoctoral fellowships in the Research School of Chemistry. We are seeking chemists for appointment from September 2001, whose scientific interests are focused in any of the areas of inorganic and organometallic chemistry; applications to organic chemistry and catalysis; transition metal and main group element clusters; chemical theory, reactivity, structure and synthesis; the study of redox-active materials; and bioinorganic chemistry. The successful candidate will have already made original contributions to some of these fields, and should be able to demonstrate a level of research independence. The positions are available in the following research groups: Inorganic and Organometallic Chemistry - Professor A. F. Hill, Coordination Chemistry and Spectro-electrochemistry - Dr G. A. Heath, and Coordination Chemistry, Kinetics and Mechanism - Dr N. E. Brasch. Information about these research groups and the Research School of Chemistry is available on the RSC web site: http://rsc.anu.edu.au/RSC/ChemResearch/Groups/List.html. Postdoctoral Fellows: Salary: Postdoctoral Fellow $40,495 - $48,867 pa, plus contributions towards travel and removal. (A successful applicant holding a PhD will be appointed at $45,666 pa minimum). Term of appointment: Subject to the availability of funding a fixed term contract of up to three years. Enquiries: Leader of research group. Applications: Further particulars and selection criteria and application forms, are available at: http://rsc.anu.edu.au/RSC/Positions/AcademicPositions/RSC_Academic_Positions.html or in the full application package in PDF format. Applications should be submitted on the appropriate form in duplicate to: the Staffing Recruitment Officer, The Australian National University, Canberra ACT 0200, quoting reference number RC 423. Contact Officer: Marilyn Holloway, Academic Secretary, Research School of Chemistry, tel: 61 2 6125 3765; fax: 61 2 6125 5995; email: Asec@rsc.anu.edu.au. Closing date: 31 August 2001.

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Announcement of Postdoctoral Research Position at Trinity University with Dr. Chris Pursell. We have an opening in our research laboratory for a postdoctoral research fellow. Funding is available for at least two years. This position is ideal for an individual who is interested in pursuing an academic position at an undergraduate college or university. While this is a full-time research position and does not require a teaching commitment, the fellow may elect to participate in teaching within the chemistry department. The research in our laboratory has focused on heterogeneous chemical reactions on ice surfaces and icelike surfaces. Most recently we have been examining the changes in the chemical reactivity of the ice surface as a function of temperature and acidity. Future studies will include studies on ice surfaces, acid doped ice, mixtures with ice and nitric acid, and surface studies involving other low temperature molecular solids. This position will also allow enough flexibility that the fellow can pursue his/her own research interests. If you have any questions, please contact Dr. Chris Pursell at cpursell@trinity.edu or (210)999-7381. Applications (a cover letter, vita, copies of transcripts, and three letters of recommendation) should be sent to: Dr. Chris Pursell, Trinity University, Chemistry Department, 715 Stadium Drive, San Antonio, Texas 78212-7200. Applications will be evaluated as received.

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Professor Marvin J. Miller of the University of Norte Dame has an opportunity to add several additional postdoctoral researchers to his group. His research group focuses on the development of synthetic methodology with applications to the synthesis and study of biologically important compounds. Overall, we have a very solid research program in organic, bioorganic and medicinal chemistry. Our facilities are outstanding, comparable to the best in the country. We have state-of-the-art NMR (three 300 MHz, one 400 MHz, one 500 MHz, and 600 MHz and plans for an 800 MHz or higher instrument in a new addition to our building currently under construction. Similarly, we have full, high level mass spectral and X-ray facilities. All of our facilities are staffed with Ph.D. level scientists to help address and solve research problems. Our laboratories are very well designed. My goal is to provide the best research and learning environment possible while maintaining a very positive, and supportive group attitude. Because of the interactive nature of the planned research program, scientifically qualified, intellectually strong applicants also should be interactive and excellent communications communicators. Excellent verbal and written skills will be expected. Independent idea generation and implementation will be strongly encouraged. Competitive stipends and University-based fringe benefits will be provided. Send to: Professor Marvin J. Miller, George & Winifred Clark Professor of Chemistry & Biochemistry, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, Indiana 46556-5670, Phone: 219-631-7058, Fax: 219-631-6652.

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A postdoctoral position is available in the Genentech Department of Protein Engineeering to study protein and peptide structure function relationships using a combination of design, diversity methods (phage display), and biophysical techniques. Projects will evaluate determinants of protein stability, peptide folding or protein-peptide interactions and may also include investigation of small moleculeprotein interactions. For recent work, see J. Am. Chem. Soc. 123, 625 (2001); J. Am. Chem. Soc. 122, 12600 (2000); Proc. Natl. Acad. Sci. USA 98, 5578 (2001). Requirements: Ph.D. in Chemistry or Biochemistry, with significant research experience in protein structure-function studies, enzymology, bio-organic chemistry, molecular evolution, or biophysics. Strong skills in either molecular biology or organic synthesis are highly desirable. Interested applicants should send a cv (including publication record and list of references) to: Andrea Cochran, Department of Protein Engineering, Genentech, MS27, I DNA Way, South San Francisco, CA 94080, or email to andrea@gene.com.

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The Department of Chemistry at Kansas State University invites applications for a postdoctoral research associate position in the research group of Professor Anne Myers Kelley to study solvent effects on the structures and optical properties of intramolecular charge-transfer molecules that have large hyperpolarizabilities. The position 'involves the measurement and computational modeling of optical absorption, fluorescence, and resonance Raman spectra, and electronic structure calculations. A Ph.D. is required and previous experience in laser spectroscopy is desirable, but highly motivated candidates from other backgrounds will be considered. The initial appointment will be for one year, renewable by mutual agreement and continued availability of funds. Applicants should send a letter of application, a curriculum vitae, a list of publications, and the names and contact information of two references to: Professor Anne Myers Kelley Department of Chemistry Kansas State University 111 Willard Hall Manhattan, KS 66506-3701 Tel. (785) 532-3843, e-mail: amkelley@ksu.edu. Further information can be found at the Kelley group Web site, http://www.ksu.edu/chem/personnel/faculty/grad/amk/kelley.html.

********************Professor Steven Kass of the University of Minnesota will have a postdoctoral position open up in his laboratory at the end of this summer. He is looking for a talented scientist to carry out Fourier transform mass spectrometry studies on electrostatic effects and zwitterionic ions, H/D exchange of biologically relevant molecules, and reactive intermediates among, other things. My laboratory is equipped with two Finnigan dual-cell FTMS instruments, one of which has an external source for carrying out electrospray experiments and the other is particularly well suited for matrix-assisted laser desorption ionization investigations. Please contact: Professor Steven Kass, University of Minnesota, 207 Pleasant Street S.E., Minneapolis, MN 55455-0431, Fax: 612-626-7541.

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Please submit all newsletter information or address changes to: goldade@chem.wisc.edu or 262-0293. Thank You.

DETAILS ARE AVAILABLE IN ROOM 1148.

NEXT NEWSLETTER IS ON AUGUST 13th, 2001.