Chemistry Newsletter - 05/15/2000

 

University of Wisconsin-Madison

Department of Chemistry Newsletter


XXXV No. 20 May 15th, 2000

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Summer Hours

Next week's newsletter will be the last regular weekly newsletter for the summer. The newsletter will go bi-weekly and will only be published on the off weeks for emergency information. Still continue to send all information for the newsletter to me in the duplicating room. The newsletter will resume weekly publication after the summer. Thank You.

Bruce Goldade - Chemistry Fast Copy Center Manager

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Finance Committee Meetings

The following dates have been confirmed for the Finance Committee Meetings this spring.

All of the meetings will be held on Tuesday from 1:20 to 3:30 PM

May 23

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Senior Care Insurance Services

Senior Care Insurance Services will be conducting informational seminars to introduce significant improvements and new benefits to the John Hancock Long-Term Care Insurance policy, which has been made available by the Group Insurance Board. The Department of Employe Trust Funds oversees this program for all state annuitants, employees, spouses and parents of employees and spouses. The following is the schedule of seminars indicating dates, locations and times:

5/24/00 10:30-12:00 Union South, 227 N Randall on campus

5/25/00 1:00-2:30 Memorial Union, 800 Langdon St on campus

To make reservations for one of the seminars call Senior Care Insurance Services. You may reach them toll-free at 877-578-8400 or you may call (608) 273-3443. You may also email seniorcr@terracom.net .

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SEMINARS

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Tuesday, May 16th, 2000 - (McElvain) - Physical Chemistry Seminar, 11:00 a.m., Room B371 Chemistry Building. Stanley Williams, Hewlett Packard. "Architectonics of Molecular Computers"

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Thursday, May 18th, and Friday May 19th, 2000 - Frontiers of Genomics IV Symposium, (Thursday 5/18) 1:00 p.m., Genetics/Biotech Center, (Friday 5/19) 8:30 a.m., and 1:30 p.m. Nobel Laureate Walter Gilbert Keynote Speaker. More Information to follow.

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Thursday-Friday. June 1st - 2nd, 2000 - Symposium Series in Developmental and Molecular Toxicology, (Thursday, 6/1) 1:00 p.m. - 9:30 p.m., (Friday, 6/2) 8:30 a.m. - 5:00 p.m. Pyle Center. Keynote Address: Dr. James Whitlock, Jr., Stanford University. "Bridging the Gap: Developmental Toxicology and Biology" addressing "Ah Receptor Mediated Disruption and Developmental Toxicology" Additional Information: http://www.wisc.edu/ehcenter , e-mail: ehsadmin@ehcenter.wisc.edu , voice: 608-262-5556.

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Dynamics and Vibrational Spectroscopy of Condensed Phases

An informal seminar on Dynamics and Vibrational Spectroscopy of Condensed Phases will begin on Friday, May 19 at 9AM in Room 3221 and continue over the summer. The first informal seminar will be Multidimensional Coherent Vibrational Spectroscopies as a Tool for Studying Interactions in Condensed Phases.

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For Industrial Positions, see the Chemistry Career Services Newsletter at:

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http://www.chem.wisc.edu/placement/7news.html

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FACULTY POSITIONS/TEMPORARY FACULTY/ACADEMIC POSITIONS

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UW-Madison Chemistry Department. Technical Assistantship - Mass Spectrometry, Chemistry Instrument Center. This position is scheduled to begin in June (summer session). We are looking for a chemistry graduate student who likes instruments and who has an aptitude for computers and an understanding of chemical structures and functional groups. Responsibilities include assisting in Chemistry 638, running mass spectra, and working with students and faculty on mass spec problems. Learning how to run all the instruments in the Mass Spectrometry Facility is part of the assistantship. If you are interested, please contact: Mass Spec Director, Dr. Martha M. Vestling, e:mail: vestling@chem.wisc.edu .

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Midland Lutheran College. A fulltime, tenure eligible, undergraduate faculty position beginning late August 2000, to teach General, Quantitative and Instrumental Analysis, and Physical Chemistry courses and occasional math courses such as Math for Liberal Arts, College Algebra and/or Elementary Statistics. Load includes student advisement and committee participation. Doctorate in Chemistry preferred, MA considered. Candidates must have a personal philosophy which is in sympathy with and supportive of the aims and objectives of a small, liberal arts, Church related college and must have primary interest in teaching and advising. Send letter of application, current resume which includes work and salary history, credentials, transcripts, and names, addresses and telephone numbers of three references to: Dr. Donald Kahnk, Academic Dean, Midland Lutheran College, Fremont, NE 68025. Review of the applications will begin 6/3/00 and will continue until the position is filled. Contact http://www.mlc.edu for general information about the college.

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EMPLOYMENT OPPORTUNITIES

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None Available for this Newsletter

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POSTDOCTORAL POSITION AND/OR JOBS

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Memorial Sloan-Kettering Cancer Center is seeking highly talented postdoctoral candidates for three separate positions open immediately in the LABORATORY FOR BIOSYNTHETIC CHEMISTRY, part of the Molecular Pharmacology & Therapeutics Program at the MEMORIAL SLOAN-KETTERING CANCER CENTER. The LABORATORY FOR BIOSYNTHETIC CHEMISTRY is currently focused upon two main arenas of research. The first is to elucidate the mechanistic details of enediyne biosynthesis/self-resistance and exploit these unprecedented biosynthetic pathways to engineer new secondary metabolites with potentially novel activity. Toward this goal we have successfully cloned the biosynthetic clusters encoding the enzymes to construct calichean&in and esperamicin, sequenced roughly 65 kb of the calicheamicin cluster, assigned putative functionality to >40 open reading frames (orfs) found of the calicheamicin cluster (and provided biochemical support for a number of these assignments), and utilized specific cal genes to reengineer glycosylation of other secondary metabolites. In addition, we have initiated mechanistic work on the unprecedented calicheamicin self-resistance metalloprotein with demonstrates an unparalleled function. Clearly this overall program is at a stage of exponential growth and will provide an excellent opportunity for motivated postdocs to make their mark. The second effort is to understand glycosyltransferase structure/function/mechanism and exploit this understanding to generate better glycosylation methods. Toward this goal we have cloned, overexpressed and purified a variety of bacterial glycosyltransferases and examined substrate specificity with various synthetic substrates. In addition, we are completing glycosyltransferase mechanistic and structural studies and have demonstrated a novel enzymatic method to generate the LJDP- and TDP-nucleotide sugars utilized by glycosyltransferases of secondary metabolism. Furthermore, structural studies and directed evolution experiments are also in progress. With these critical models in hand, we are now considering their use in diplaying "useful" carbohydrate antigens on bacterial surfaces and or secondary metabolites. Thus, through the hard work of inspired and talented postdocs, success of this research should also present high visibility. Because of the multi-disciplinary nature of the work, individuals from a broad range of backgrounds are encouraged to apply. Candidates with training in protein biochemistry, mechanistic enzymology, molecular biology, Streptomyces genetics and/or carbohydrate/natural product isolation/synthesis are particularly appropriate. Interested candidates should send a CV and the names of three references to: Jon Thorson, LABORATORY FOR BIOSYNTHETIC CHEMISTRY, MSKCC, Box 309, 1275 York Avenue, NY, NY 10021.

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Dartmouth College. An unexpected opening has become available in my group for a postdoctoral associate, starting as early as August 1, 2000, for one year. Applicants should have a PhD in Chemistry, and be familiar with the methods of synthesis and characterization of air sensitive organometallic compounds, particularly Schlenk and Drybox work, and NMR spectroscopy. The project involves studies of the activation of carbon-fluorine bonds by late transition metal centers. Recent publications in this area can be found in: Hughes, R. P.; Lindner, D. C.; Rheingold, A. L.; Liable-Sands, L. M. J. Am. Chem. Soc. 1997, 119, 11544-11545. Hughes, R. P.; Smith, J. M. J. Am. Chem. Soc. 1999, 121, 6084-6085. Please bring this notice to the attention of any prospective applicants, and have them contact me by email initially. Russell P. Hughes Frank R. Mori Professor of Chemistry Dartmouth College 6128 Burke Laboratories Hanover NH 03755-2564 USAVoice: (603)646-2763 FAX: (603)646-3946 (not confidential) URL: http://www.dartmouth.edu/~rph

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Brown University. A postdoctoral position in photoacoustics is immediately available at Brown University. Projects involve photoacoustic detection and identification of trace molecules, transient grating investigations of nonlinear sources, production of voltages by laser induced thermal gradients, and new methods for spectroscopic investigation of forbidden transitions in molecules. Candidates should send a CV and the names of two references to: Matthew B. Zimmt, Dept. of Chemistry, Brown University, Providence, RI 02912. Phone: 401-863-2909, Fax: 401-863-2594, E-mail: Matthew_Zimmt@Brown.Edu .

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Please submit all newsletter information or address changes to: goldade@chem.wisc.edu or 262-0293. Thank You.

DETAILS ARE AVAILABLE IN ROOM 1380.

NEXT NEWSLETTER IS ON MAY 22nd, 2000.