Chemistry Newsletter - 05/08/2000

 

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Department of Chemistry Newsletter

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XXXV No. 19 May 8th, 2000

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Congratulations!!

In recognition of his accomplishments and contributions to teaching, Rodney Schreiner was inducted as a Fellow of the University of Wisconsin-Madison Teaching Academy on April 16, 2000. For the last twenty years, Rod has lectured in the General Chemistry Division, and he has developed course materials in a variety of media, including print, video, audio, and computer software, that have been used by many in general chemistry. He has also coauthored several publications that have been used around the world and have been translated into other languages. He has also been active in outreach to teachers, students, and the general public. For teachers, he has taught in workshops offered by the Institute for Chemical Education, in Chautauqua Short Courses, and in programs of the National Science Teachers Association. For the public, he has given presentations at local, regional, and national professional society meetings, he developed several interactive chemical demonstrations that are on display at the Chicago Museum of Science and Industry, and he recently presented 30 shows at the EPCOT Center in Florida. Congratulations to Rod for this recognition of his work.

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Congratulations!!

Stacy J. Keding, a fourth year graduate student working with Professor Rich, has won a $20,000 Fellowship awarded annually by the Medicinal Chemistry Division of the American Chemical Society. Stacy is working on the design and synthesis of inhibitors of bleomycin hydrolase and methionine aminopeptidase. Congratulations to Stacy!

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Finance Committee Meetings

The following dates have been confirmed for the Finance Committee Meetings this spring.

All of the meetings will be held on Tuesday from 1:20 to 3:30 PM

May 23

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The selection of Divisional Chairs for the 2000-01 year have been completed. The Divisional Chairs will be:

Analytical Sciences Lloyd Smith
General Chemistry John Moore
Inorganic Chemistry Paul Treichel, Jr.
Organic Chemistry Hans Reich (until January 2001)
Sam Gellman (Starting January 2001)
Materials Chemistry Robert Hamers
Physical Chemistry James Skinner

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SEMINARS

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Monday, May 8th, 2000 - Inorganic Chemistry Seminar (ACS Speaker), 2:25 p.m., Room B371 Chemistry Building. Michael Fryzuk.

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Monday, May 8th, 2000 - Madison Mass Spectrometry Discussion Group, 7:30 p.m., Room 1360 Biotechnology Center. Dr. Ian Jardine, President LC and LC/MS Division of ThermoQuest. "Ultra High Throughput Proteomics and Ion Traps Tandem Mass Spectrometry"

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Tuesday, May 9th, 2000 - Physical Chemistry Seminar, 11:00 a.m., Room 8335 Chemistry Building. David Grier, University of Chicago. "When Like Charges Attract: Surprises in Macroionic Interactions"

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Tuesday, May 9th, 2000 - Chemical Engineering Seminar, 3:55 p.m., Room 1227 Engineering Hall. Pablo G. Debenedetti, Princeton University. "Towards an Improved Understanding of the Glassy State"

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Wednesday, May 10th, 2000 - Inorganic Chemistry Seminar, 3:30 p.m., Room B371 Chemistry Building. Chris Staples, UW-Biochemistry.

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*****CANCELED - Rescheduled For Next Year***** Thursday, May 11th, 2000 - CBI Highlights Lecture, 2:25 p.m., Room 3335 Sterling. Professor Jeff Johnson, UW-Madison. "Transcriptional Activation of the Antioxidant Response Element by Hydroquinones"

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Tuesday, May 16th, 2000 - (McElvain) - Physical Chemistry Seminar, 11:00 a.m., Room B371 Chemistry Building. Stanley Williams, Hewlett Packard. "Architectonics of Molecular Computers"

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Thursday, May 18th, and Friday May 19th, 2000 - Frontiers of Genomics IV Symposium, (Thursday 5/18) 1:00 p.m., Genetics/Biotech Center, (Friday 5/19) 8:30 a.m., and 1:30 p.m. Nobel Laureate Walter Gilbert Keynote Speaker. More Information to follow.

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Thursday-Friday. June 1st - 2nd, 2000 - Symposium Series in Developmental and Molecular Toxicology, (Thursday, 6/1) 1:00 p.m. - 9:30 p.m., (Friday, 6/2) 8:30 a.m. - 5:00 p.m. Pyle Center. Keynote Address: Dr. James Whitlock, Jr., Stanford University. "Bridging the Gap: Developmental Toxicology and Biology" addressing "Ah Receptor Mediated Disruption and Developmental Toxicology" Additional Information: http://www.wisc.edu/ehcenter , e-mail: ehsadmin@ehcenter.wisc.edu , voice: 608-262-5556.

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Recent Publications

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Courtenay ES; Capp MW; Anderson CF; Record MT.

Vapor pressure osmometry studies of osmolyte-protein interactions: Implications for the action of osmoprotectants in vivo and for the interpretation of "osmotic stress" experiments in vitro.

BIOCHEMISTRY 2000, Vol 39, Iss 15, pp 4455-4471.

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Vedejs E; Chapman RW; Lin S; Muller M; Powell DR.

Crystallization-induced asymmetric transformation vs quasi-racemate formation in tetravalent boron complexes.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2000, Vol 122, Iss 13, pp 3047-3052.

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Vedejs E; Wang JB.

A tyrosine-derived benzofuranone related to diazonamide A.

ORGANIC LETTERS 2000, Vol 2, Iss 8, pp 1031-1032.

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Vedejs E; Barda DA.

Progress toward synthesis of diazonamide A. Preparation of a 3-(oxazol-5-yl)-4-trifluoromethyl-sulfonyloxyindole and its use in biaryl coupling reactions.

ORGANIC LETTERS 2000, Vol 2, Iss 8, pp 1033-1035.

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Zimmerman HE; Nesterov EE.

Crystal lattice photochemistry often proceeds in discrete stages. Mechanistic and exploratory organic photochemistry.

ORGANIC LETTERS 2000, Vol 2, Iss 8, pp 1169-1171.

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Cayley DS; Guttman HJ; Record MT.

Biophysical characterization of changes in amounts and activity of Escherichia coli cell and compartment water and turgor pressure in response to osmotic stress.

BIOPHYSICAL JOURNAL 2000, Vol 78, Iss 4, pp 1748-1764.

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Sohn H; Woo HG; Powell DR.

Synthesis and structural characterization of a silacycloheptadiene.

CHEMICAL COMMUNICATIONS 2000, Vol , Iss 8, pp 697-698.

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Bretscher LE; Abel RL; Raines RT.

A ribonuclease A variant with low catalytic activity but high cytotoxicity.

JOURNAL OF BIOLOGICAL CHEMISTRY 2000, Vol 275, Iss 14, pp 9893-9896.

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Jacobsen JJ; Moore JW.

Chemistry Comes Alive!, Volumes 1 and 2 - Announcement of second editions of special issues 18 and 21.

JOURNAL OF CHEMICAL EDUCATION 2000, Vol 77, Iss 5, pp 671-672.

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Hans JJ; Driver RW; Burke SD.

Direct transacylation of 2,2,2-trihaloethyl esters with amines and alcohols using phosphorus(III) reagents for reductive fragmentation and in situ activation.

JOURNAL OF ORGANIC CHEMISTRY 2000, Vol 65, Iss 7, pp 2114-2121.

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Ludwig R; Weinhold F.

Quantum cluster equilibrium theory of liquids: light and heavy QCE/3-21G model water.

PHYSICAL CHEMISTRY CHEMICAL PHYSICS 2000, Vol 2, Iss 8, pp 1613-1619.

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Copyright � 2000 Institute for Scientific Information

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MILLER RESEARCH FELLOWSHIPS FOR 2001-2004

Nomination Deadline: October 5, 2000

The Miller Institute for Basic Research in Science invites you to assist the faculty scientists at the University f California at Berkeley in nominating candidates for Miller Research Fellowships in the basic sciences. The Miller Institute seeks to discover and encourage individuals of outstanding talent, and to provide them with the opportunity to pursue their research. Fellows are selected on the basis of their academic achievement end the promise of their scientific research. Each Miller Fellow is sponsored by a department of the Berkeley campus and performs his or her research in the facilities provided by the department. The Fellowships are intended for brilliant young women and men of great promise who have recently been awarded, or who are about to be awarded, the doctoral degree. The deadline for nominations this year is October 5, 2000. No nominations will be accepted that arrive later than this date. Early nominations are encouraged and will provide the nominee with more time to prepare their application. Your letter of nomination must include the following information:

1) Nominee's complete current mailing address, E-mail address, and current telephone number

2) (Anticipated) Date of Ph.D.

3) Your recommendation and judgement of candidate's promise

This letter of nomination need not be lengthy, but should include all of the information requested above. To ensure that nominees receive correspondence, the nomination letter must provide accurate and complete mailing and telephone contact information. In addition to the above items, the Executive Committee also finds it helpful in the nomination letter to have the candidate compared with others who are at a similar stage in their development. Suitable nominees will be invited to submit documentation supporting their nomination. Such materials will be accepted only following an invitation from the Institute. Additional letters of support will be requested from those other than the nominator. Direct applications are not accepted. Please note that persons already in positions on the Berkeley campus are not eligible for nomination or receipt of an award, Non-US citizens are eligible for nomination, however, such candidates must be eligible for a J-l scholar visa for the duration of the Fellowship The Institute will provide an annual stipend of $45,000 and a contingency fund of $5,000 per annum. There is provision for travel to Berkeley for Miller Fellows and their immediate families and a maximum allowance of $3,000 for removal of personal belongings. The Miller Institute also provides health and dental insurance. Fellowships are awarded for three Years beginning August 1, 2001 and ending July 31, 2004. Approximately eight to ten Fellowships are awarded each year. Candidates will be notified of the results of the competition in early January 2001, and a general announcement of the awards will be made in spring.

For more information on the Miller Institute's programs please view their web page at: http://socrates.berkeley.edu/~4mibrs . Contact: Miller Institute for Basic Research in Science, 2536 Channing Way, Berkeley, California 94720-5190, phone: 510-642-4088, fax: 510-643-7393, e-mail: 4mibrs@socrates.berkeley.edu .

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For Industrial Positions, see the Chemistry Career Services Newsletter at:

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http://www.chem.wisc.edu/placement/7news.html

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FACULTY POSITIONS/TEMPORARY FACULTY/ACADEMIC POSITIONS

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None Available for this Newsletter

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EMPLOYMENT OPPORTUNITIES

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Candidates needed for Research Assistant and Research Associate positions in Medicinal Chemistry at Advanced Medicine, Inc. Located in South San Francisco, AMI is dedicated to the discovery of novel therapeutic agents. The Company is led by experienced management and advisors from the top ranks of the health care, business, and academic communities. We enjoy strong and stable financing, and we have placed the highest priority on creating a vigorous, productive, and collegial intellectual environment that fosters professional growth. As members of our Medicinal Chemistry group, RAs will participate in the design, synthesis, purification, and characterization of novel biologically active molecules. In the case of positions within our Combinatorial/High-Throughput team, they will use automated instrumentation for the synthesis and purification of compound arrays. They will contribute to new target evaluation, exploratory research and lead optimization projects, collaborating closely with colleagues in our Biochemistry and Pharmacology groups on critical Project Teams. Primary requirements for these positions include a keen motivation to contribute, learn, and grow within the context of our vigorous and supportive team environment. We are particularly interested in students who have 1-2 years of research experience in synthetic chemistry or a related discipline, and we encourage applications from candidates who would like to work in a stimulating industrial research environment for two or more years prior to attending graduate school. In addition, we would gladly consider for Senior Research Associate positions former students who have gone on to gain medicinal chemistry experience and distinguish themselves in an industrial setting. Interested parties should forward a resume with reference list along with a cover letter to: Advanced Medicine, HR Department (ATTIC Job# 99-0041/046), 901 Gateway Boulevard, South San Francisco, CA 94080. They may also respond by email to: career@advmedicine.com or see our web page at http://www.advmedicine.com .

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Chemical Kinetics Modeling Principle Investigator. ExxonMobil Research and Engineering Corporate Strategic Research Laboratory, Clinton, New Jersey. We are seeking a principal investigator to join our team, which is developing detailed kinetic models and the associated experimental database to describe hydrocarbon reaction systems, with particular emphasis on high-temperature, gas-phase pyrolysis and oxidation chemistry. Our goal is to couple this chemistry with the appropriate transport equations to describe various reaction environments, with particular emphasis on internal combustion engines. This individual will initially be responsible for the continuation of our efforts to develop detailed chemical kinetic mechanisms to quantitatively describe the complex free-radical chemistry that occur in high temperature environments. For the programs we have related to fuels for advanced vehicles, the emphasis is on developing a fundamental understanding of how chemical structure impacts ignition, flame propagation, and pollutant formation processes. These efforts will include development of computer algorithms that systematically build detailed chemical mechanisms, incorporating rate constants from experiment and built from rules based on fundamental kinetic principles. This person will be involved in a team effort with researchers both at ExxonMobil and auto industry company collaborators. The kinetic model development draws heavily on collaboration with other team members and constructive interactions are critical to success. The critical skills needed will typically be those found in Ph.D. level physical chemists or chemical/mechanical engineers that have had extensive experience in constructing detailed kinetic models. A solid background in gas phase reaction rate theory and thermochemical kinetics is essential. Expertise in ab-initio electronic structure theory would be advantageous, both in construction of potential energy surfaces for reacting systems and use of these surfaces to compute thermal rate constants. In addition, familiarity with experimental kinetic measurement techniques is desired. Additional information about the position can be obtained by contacting Dr. Anthony Dean; phone: 908-730-2727, e-mail: amdean@erenj.com . Please send your resume and three letters of reference to: Human Resources Recruiting - PIKIN, ExxonMobil Research and Engineering Company, P. O. Box 998, Annandale, NJ 08801-0998.

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Institute of Atomic and Molecular Sciences (IAMS) - Chemical Dynamics Laboratory. A permanent staff position is available immediately in the research group of Dr. Kopin Liu at IAMS, Academia Sinica, Taiwan. This tenure-track position is initially at the level of assistant research fellow. Applicants should have a Ph.D. in chemistry or physics and an excellent track record in research in the general area of gas phase physical chemistry or chemical physics. Two years postdoctoral experience is desirable. All highly motivated physical chemists or physicists are encouraged to apply. Experience in high-resolution laser spectroscopy, molecular-beam techniques, and computer interfacing of experiments would be preferred, however, the most critical criterion is creativity. The initial appointment will be for four years in collaboration with Dr. Kopin Liu. We anticipate that the candidate will eventually establish his/her own research program upon promotion. The current experimental programs in our group include (i) crossed-beam studies of radical reaction dynamics; (ii) molecular photophysics and photochemistry in and on clusters; and (iii) developing a novel scheme of coherent control of atomic and molecular processes. All three projects are fairly challenging and involve a variety of state-of-the-art experimental techniques. The IAMS is rapidly developing into one of the world's prime research institutions, offering excellent working conditions and technical support. Additional information can be glanced at http://kliu.iams.sinica.edu.tw/. Applications with three letters of recommendation, full curriculum vitae including a list of publications should be sent to: Dr. Kopin Liu, Institute of Atomic and Molecular Sciences, Academia Sinica, P.O. Box 23-166, Taipei 10764, Taiwan Fax: 886-2-2362-0200 e-mail: kpliu@gate.sinica.edu.tw http://kliu.iams.sinica.edu.tw/

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Technical Assistantship - UW-Madison Chemistry Department. Mass Spectrometry, Chemistry Instrument Center This position is scheduled to begin in June (summer session). We are looking for a chemistry graduate student who likes instruments and who has an aptitude for computers and an understanding of chemical structures and functional groups. Responsibilities include assisting in Chemistry 638, running mass spectra, and working with students and faculty on mass spec problems. Learning how to run all the instruments in the Mass Spectrometry Facility is part of the assistantship. If you are interested, please contact: Mass Spec Director, Dr. Martha M. Vestling vestling@chem.wisc.edu .

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POSTDOCTORAL POSITION AND/OR JOBS

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Postdoctoral/Lecturer: Inorganic Chemistry. The University of Memphis, Department of Chemistry, invites applications for a postdoctoral/lecturer position beginning August 2000. The successful candidate will perform research on transition metal complexes while gaining teaching experience at the university level. Applicants must be experienced in the synthesis of organometallic compounds, be familiar with common purification and characterization techniques, and should have, or expect to have, a Ph. D. degree before the starting date. Applicants should submit a curriculum vita and arrange to have two letters of recommendation and graduate transcripts sent to: Dr. R. Gregory Peters, Chemistry Department, The University of Memphis, Memphis, TN 38152. Screening of applications will begin June 1, 2000 and the search will remain open until the position is filled.

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Please submit all newsletter information or address changes to: goldade@chem.wisc.edu or 262-0293. Thank You.

DETAILS ARE AVAILABLE IN ROOM 1380.

NEXT NEWSLETTER IS ON MAY 15th, 2000.